Dr. Axe

Fighting Free Radicals & Free Radical Damage

Antioxidants, ORAC scores, free radicals and oxidative stress: These things have become trendy topics as far as health and longevity are concerned. Perhaps you’ve recently jumped on the antioxidant supplement bandwagon, or maybe you remain wary of manufacturers’ liberal use of these latest buzzwords, unsure of whether they’re safe or effective?

Many people have heard that foods with antioxidants protect us from free radical damage, which is responsible for many of the effects of aging on both the body and mind. But what exactly are free radicals, why are they bad and where do they come from?

When antioxidant levels in the body are lower than those of free radicals, due to factors like poor nutrition or lots of incoming toxins, the immune system is overloaded and aging occurs more rapidly. In order to know how to best protect yourself from health problems linked to free radical damage — and there are many — it helps to understand what types of lifestyle habits or dietary choices cause them to accumulate in the first place. As you’ll learn below, a diet rich in a variety of plant foods along with things like exercise and stress reduction help reverse the destructive oxidation process.

What Are Free Radicals and How Do They Cause Damage?

The definition of free radicals is “uncharged molecules (typically highly reactive and short-lived) having an unpaired valence electron.” According to the Pharmacognosy Review, “reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states.” (1)

Free radicals can be very harmful, but their production within the body is certainly not abnormal or even entirely bad. Despite contributing to the aging process, free radicals are also essential players in the immune system. Our bodies produce free radicals as byproducts of cellular reactions, metabolism of foods, breathing and other vital functions. (2) The liver produces and uses free radicals for detoxification, while white blood cells send free radicals to destroy bacteria, viruses and damaged cells.

Why are free radicals thought to be dangerous then? As naturopath Dr. Stephen Byrnes explains, free radicals are unstable molecules, meaning they’re always on the lookout for chemical components that other cells have but that they themselves are missing.

Electrons exist in pairs, and free radicals are missing an electron. This is their weapon of sorts: Free radicals “react” with just about anything they come into contact with, robbing cells and compounds of one of their electrons. (3) This process makes the affected (“robbed”) cell or compound unable to function normally and turns some cells into electron-seeking muggers themselves, leading to a chain reaction in the body and the proliferation of even more free radicals. The clean-up crew, our immune system’s “soldiers,” lose their control and end up marauding and pillaging throughout the body, destroying healthy cells and tissues.

What Is “Oxidative Stress,” and How Do Antioxidants Fit In?

Free radicals ultimately harm and age the body over time because they damage DNA, cellular membranes, lipids (fats) stored within blood vessels and enzymes. Normally, free radicals — or as they’re also commonly referred to, reactive oxygen species and reactive nitrogen species — live in balance with antioxidants in the body. It’s when this balance is disturbed, due to low intake of antioxidants and accumulation of free radicals, that accelerated aging occurs.

The damage done by free radicals in the body is known as oxidation:

Antioxidants counteract free radicals because they’re essentially “self-sacrificing soldiers.” As Byrnes explains, they donate an electron to free radicals to “calm” them down and are consumed in the process.

Our bodies use antioxidants to lessen the impact of free radicals, and our diets give us the tools to do so. Glutathione is considered the most important “master” antioxidant and is the liver’s major weapon. It’s created from the amino acids cysteine, glycine and glutamic acid.

Other major antioxidants that have been identified include some you’re likely familiar with, such as vitamins A, C and E; beta-carotene; bioflavonoids; CoQ10; selenium; and zinc. Copper and manganese have roles in antioxidant production as well.

Many other phytochemicals from plants also seem to play antioxidant roles. We usually think of these chemicals — like lycopene, tannins, phenols, lignans or quercetin, for example— as antioxidants even though the body doesn’t make them on its own. Once consumed they help reduce inflammation and the effects from oxidation. (4)

Here are some of the roles that antioxidants have:

Our ability to produce antioxidants in the body declines with age, says Mayo Clinic’s Dr. Donald Hensrud. The reason that antioxidants are often touted as “anti-aging” compounds is because they help protect us from age-related diseases, which are caused in part by free radicals and inflammation. While we can never entirely stop the aging process, as diet high in antioxidant foods helps us age much more gracefully — living longer, healthier, more vibrant lives.


Major Sources of Free Radicals

So what causes free radicals to proliferate? Basically, the typical “Western lifestyle” — with its processed foods, absence of healthy whole foods, reliance on medications and antibiotics, common use of alcohol or drugs, environmental pollutants, and high stress levels. Free radicals are generated due to oxidation and when toxins are broken down in the body. The liver produces free radicals as it breaks down compounds and removes them.

The major sources of free radicals include: (5)

Best Ways to Fight Free Radical Damage

1. Start Eating More Foods Rich in Antioxidants

The National Institute on Aging, a part of the National Institutes of Health, developed a scoring system to measure the amounts of antioxidants in foods. The score given to a particular food is known as its ORAC score. ORAC stands for “Oxygen Radical Absorbance Capacity.” Unfortunately, the National Institutes of Health decided to remove the ORAC database in 2012, but these scores are still available via Superfoodly.

Here are just a few foods that have very high ORAC scores:

While eating more antioxidant foods is a big step in the right direction, you also benefit from limiting intake of pesticide- and herbicide-laden foods (those that are not organically grown) and by avoiding too much sugar, refined oil or refined grains. Use natural, cold-pressed oils like coconut or olive oil, since heat oxidizes fats in refined oils. And be sure to limit intake of antibiotic- and hormone-laden foods, such as farm-raised meat or fish.

2. Avoid Toxin or Pollutant Exposure

Besides improving your diet, here are other ways to start reducing free radical damage:


Will Supplements (such as Those Marketed as ‘Antioxidants’) Combat Free Radicals?

According to some experts, there are literally thousands of different antioxidants in the human diet, and they exist in many different forms. Because of the complexities of how antioxidants work in the body to combat free radicals, some scientists believe that only in food form do phytonutrients or antioxidants interact beneficially with our bodies.

Author of “In Defense of Food,” Michael Pollan, calls this obsession with finding the magical and pivotal ingredient in foods “nutritionism” and “reductionist science” and believes that it actually promotes unhealthy eating. Looking at foods from the perspective of the specific nutrients they contain dissolves “distinctions between processed foods and whole foods,” Pollan says. It’s easier to post “contains essential vitamins and minerals” or “contains antioxidants vitamins C and E” on a box of processed cereal than it is to label a banana or a carrot in the same way.

Surveys shows that about 30 percent of Americans are taking some form of antioxidant supplement. (10) But the American Heart Association, along with the Mayo Clinic and Cleveland Clinic, recommend getting antioxidants naturally from whole foods, an unprocessed diet with a wide variety of fruits and veggies, rather than from supplements.

Hensrud points out that most foods with high ORAC scores (like cocoa, green tea or acai berries, for example) offer great benefits beyond just supplying antioxidants, such as containing fiber, protein, vitamins and minerals. All of these compounds work together synergistically, and therefore these foods are “greater than the sum of their parts.”

Based on all of the information above, you can see that while it’s helpful to be aware of individual antioxidants and their benefits, the bigger goal regarding prevention of free radical damage is to focus on consuming a wide variety of nutrient-dense, whole foods. At the same time, it’s important to reduce the toxin load in your body by removing things like unnecessary medications, too much stress and pollutants from your life.

Precautions Regarding Free Radicals

With the invention of anti-aging supplements, experts now worry that people may rely on supplements to counteract unhealthy lifestyle choices and poor nutrition. There’s also the risk that consuming high doses of concentrated antioxidants from supplements may compromise the defensive role of free radicals in the immune system or have other problematic effects like interfering with proper exercise recovery.

The bottom line is that according to studies, isolating specific antioxidants and consuming them from pills to lower free radicals isn’t very helpful, especially compared to eating whole foods. Variety and interaction of many different antioxidants as they exist in food seem to be most beneficial for longevity and optimal health.

Final Thought on Free Radicals

Read Next: Top 10 High Antioxidant Foods

From the sound of it, you might think leaky gut only affects the digestive system, but in reality it can affect more. Because Leaky Gut is so common, and such an enigma, I’m offering a free webinar on all things leaky gut. Click here to learn more about the webinar.