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Energy · ranked by evidence

Best supplements for energy

Ranked the way I'd rank them in clinic: by the strength of the human evidence and how often the shortfall actually shows up. Start at the top. Add the rest only if labs or symptoms say so.

  1. Iron (only if ferritin is low)

    The single most common fixable cause of fatigue in women.

    Strong evidence
  2. Vitamin B12 (methyl)

    Especially for vegans, people over 50 and anyone on acid blockers.

    Strong evidence
  3. Vitamin D3

    Low levels track with fatigue and low mood.

    Strong evidence
  4. Magnesium glycinate

    Cellular energy production and better sleep.

    Strong evidence
  5. CoQ10 (ubiquinol)

    Mitochondrial energy; essential if you take a statin.

    Moderate evidence
  6. Rhodiola

    Fatigue and stress performance; morning only.

    Moderate evidence
  7. Creatine monohydrate

    Energy at the cellular level; a growing brain story.

    Strong evidence

Test before you supplement

Test first: ferritin, B12/MMA, vitamin D, Free T3, fasting insulin. Interpret a result →

Put it in order

Supplements are step three. The Energy Guides put food, lifestyle and labs in front of them, in the order that works.

Reviewed by specialists in endocrinology, functional medicine, cardiology, nutrition and longevity.Our protocols and source library are reviewed against current clinical evidence by our medical advisory board. Dr. Axe AI grounds its answers in that reviewed library and shows the sources behind every response.
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