Health A–Z · Biomarkers & lab tests

Biomarkers & lab tests, A to Z

The numbers on your labs, explained.

Search by name, another name (hs-CRP, ferritin, 25-hydroxy) or a question (inflammation, thyroid, hormones). Misspellings are fine.

  • 68markers & measures
  • 9questions your labs answer
  • 6test panels to ask for

Upload a report and see every marker against functional and conventional ranges, free.

Normal isn’t the same as optimal

Every result on DrAxe.com is read against two ranges: the functional range first, then your lab’s conventional range.

Functional vs conventional

Functional medicine ranges are the window where the body heals and functions optimally.

Your lab’s range is built to catch disease, so a result can sit inside it and still be outside the optimal range. That’s often where you can still turn things around.

Example: vitamin D
0305080100+
Optimal: inside the functional range, 50–80 ng/mL.
Outside optimal range: inside the lab’s range, outside the functional range. A result of 32 lands here, even though most lab reports call it normal.
Outside the lab’s range: below 30 ng/mL. Talk with your doctor about these results.

Ranges from Dr. Axe’s 25 Markers guide, the same ranges the Lab Interpreter uses.

Functional Medicine ReportSample · not a real patient
72OF 100
Health Score
72 of 100
Biological age
42 vs 49 actual
3 areas need attention
Mitochondria61
Inflammation64
Hormones68
Key markers vs functional range
Vitamin D28 ng/mLBelow lab range
hs-CRP2.4 mg/LOutside optimal
Ferritin32 ng/mLOutside optimal
Fasting insulin9.1 µIU/mLOutside optimal
ApoB78 mg/dLOptimal
Pattern: elevated hs-CRP, low vitamin D and higher fasting insulin together suggest blood-sugar stress may be feeding inflammation. The 90-day plan starts with food, a few targeted supplements and a retest.
Your bloodwork, read the root-cause way

See what your report could look like

One report with a health score, an estimated biological age, your key markers against functional ranges, the patterns that connect them and a 90-day plan you can share with your doctor.

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See the full sample report

Tests to ask for

A standard panel skips many of the markers that show what’s happening early. Take these lists to your doctor, or see Dr. Axe’s recommended bloodwork.

See bloodwork options

Popular and new in biomarkers

The biomarkers pages readers open most on DrAxe.com, and the newest ones.

Every biomarker and lab test, A to Z

Pick a letter, filter by goal or type, or search the list. Other names are listed too.

72 entries

Cellular healthInflammation, blood sugar and energy
  1. 1
    hs-CRPThe master signal of systemic inflammation
    Optimal< 1.0 mg/LLab< 3.0 mg/L
  2. 2
    HbA1cA 90-day window into metabolic health
    Optimal4.8 – 5.3%Lab< 5.7%
  3. 3
    Fasting InsulinThe earliest warning of metabolic decline
    Optimal2 – 8 µIU/mLLab< 25 µIU/mL
  4. 4
    Omega-3 IndexCell membrane integrity made measurable
    Optimal≥ 8 %Lab≥ 4 %
  5. 5
    CoQ10The mitochondrial energy molecule
    Optimal2.5 – 3.5 µg/mLLab0.4 – 2.0 µg/mL
  6. 6
    GGTThe earliest glutathione depletion signal
    OptimalMen < 25 · Women < 17 U/LLab< 50 U/L
  7. 7
    F2-IsoprostanesThe gold-standard oxidative stress marker
    Optimal< 1.0 ng/mg creatinineLabVariable by lab
  8. 8
    Lp(a)The genetic cardiovascular wildcard
    Optimal< 30 mg/dL (or < 75 nmol/L)LabRarely tested
Vitamins & mineralsThe nutrients your cells run on
  1. 9
    Vitamin DA hormone, not a vitamin — touching every cell
    Optimal50 – 80 ng/mLLab> 30 ng/mL
  2. 10
    RBC MagnesiumThe mineral cofactor for 600+ enzymes
    Optimal5.5 – 6.5 mg/dLLab4.0 – 6.4 mg/dL
  3. 11
    MMA (B12 Status)True cellular B12 status
    Optimal< 270 nmol/LLab< 400 nmol/L
  4. 12
    FerritinIron status — deficiency and overload both kill
    OptimalWomen 50–150 · Men 75–150 ng/mLLabWomen 15–150 · Men 15–400 ng/mL
  5. 13
    RBC ZincThe immunity and hormone mineral
    Optimal12 – 14 mg/LLab9 – 14 mg/L
  6. 14
    RBC SeleniumThe thyroid and glutathione mineral
    Optimal180 – 240 µg/LLab120 – 300 µg/L
  7. 15
    Copper : Zinc RatioMineral balance, not isolated values
    OptimalRatio 0.7 – 1.0LabReported separately
Hormones, heart & gutThe signals that steer your health
  1. 16
    Thyroid PanelThe complete thyroid picture, not just one number
    OptimalTSH 0.5–2.0 · fT3 3.4–4.4 · fT4 1.3–1.6 · TPO/TgAb < 9LabTSH 0.4–4.5 · fT3 2.3–4.2 · TPO < 35
  2. 17
    ApoBThe true count of atherogenic particles
    Optimal< 80 mg/dLLab< 100 mg/dL
  3. 18
    GI-MapThe hidden ecosystem behind every illness
    OptimalBalanced flora, no pathogens, low calprotectinLabStandard stool culture misses 80%
  4. 19
    CortisolRhythm beats single-point measurement
    Optimal10–18 µg/dLLab6–23 µg/dL
  5. 20
    Free TestosteroneThe bioavailable vitality hormone
    OptimalMen 15–25 · Women 1.5–2.5 pg/mLLabMen 5–21 · Women 0.1–6.4 pg/mL
  6. 21
    EstradiolThe dominant female sex hormone
    OptimalMen 20–30 pg/mL · Premenopausal women (draw day 19–21) 80–200 pg/mL, with progesterone >10 ng/mL · Postmenopausal women 20–60 pg/mL on HRTLabMen 8–40 pg/mL · Premenopausal women (draw day 19–21) 40–250 pg/mL · Postmenopausal women <30 pg/mL
  7. 22
    ProgesteroneThe calming hormone of cycle and sleep
    OptimalLuteal 15–25 ng/mL · Postmen < 1LabLuteal 5–20 ng/mL
  8. 23
    DHEA-SAdrenal reserve and longevity marker
    OptimalMen 200–400 µg/dL · Women 150–300 µg/dLLabMen 80–560 µg/dL · Women 35–430 µg/dL (age-banded)
  9. 24
    HomocysteineThe functional methylation readout
    Optimal< 7 µmol/LLab< 15 µmol/L

Read the 25 Markers guide

A

3 entries
  • AMPKAlso called AMP-activated protein kinaseAn enzyme that senses low energy in cells and switches on fuel burning.
  • ApoBAlso called Apolipoprotein B · Apo BCounts the particles that carry cholesterol into artery walls.
  • AutophagyThe way cells break down and recycle their own worn-out parts.
  • ALT → see Liver function
  • AST → see Liver function
  • ATP → see Mitochondria

B

8 entries

C

9 entries

D

1 entries
  • DHTAlso called DihydrotestosteroneA potent androgen hormone the body makes from testosterone.

E

3 entries
  • ElectrolytesCharged minerals like sodium and potassium that control fluid, nerves and muscles.
  • EpinephrineAlso called AdrenalineThe fight-or-flight hormone your adrenal glands release under stress.
  • EstradiolAlso called E2 · OestradiolThe main and strongest form of estrogen made in the body.
  • E2 → see Estradiol

F

2 entries

G

4 entries
  • Galectin-3Also called Gal-3A protein tied to inflammation and tissue scarring, measured by a blood test.
  • GhrelinA stomach hormone that rises before meals to signal hunger.
  • GlucagonA pancreas hormone that raises blood sugar when it drops too low.
  • GlycogenThe stored form of glucose that your liver and muscles keep for energy.
  • Gal-3 → see Galectin-3
  • GGT → see Liver function

H

4 entries

I

4 entries
  • IGF-1Also called Insulin-like growth factor 1 · Somatomedin CA growth factor the liver makes in response to growth hormone.
  • InflammagingAlso called Inflamm-agingLow-grade, chronic inflammation that tends to rise with age.
  • IodineA mineral your thyroid needs to make its hormones.
  • IronA mineral your red blood cells need to carry oxygen through the body.
  • IL-6 → see Cytokines

K

1 entries
  • KetosisA metabolic state in which the body burns fat and makes ketones for fuel.

L

4 entries
  • Lactic acidAlso called LactateA byproduct muscles make when they burn glucose faster than oxygen can keep up.
  • Leaky gut testAlso called Intestinal permeability testChecks how easily substances pass through the lining of your intestines.
  • LeptinA hormone from fat cells that signals fullness and energy stores.
  • Liver functionHow well your liver filters blood, processes nutrients and clears toxins.

M

5 entries

N

2 entries
  • Nitric oxideA gas the lining of your blood vessels makes to relax and widen them.
  • NorepinephrineAlso called NoradrenalineA stress hormone and brain messenger that raises alertness, heart rate and blood pressure.

O

3 entries
  • Omega-3Also called Omega-3 fatty acidsEssential fats from fish and seeds that support the heart, brain and cell membranes.
  • Oxidative stressAlso called Free radical damageCell damage that happens when free radicals outpace the body's antioxidant defenses.
  • OxytocinA hormone released during touch, childbirth and nursing that supports bonding.

P

2 entries

S

4 entries
  • SeleniumA trace mineral used by antioxidant enzymes and the thyroid.
  • Skin turgor testAlso called Skin pinch testA quick pinch test of how fast skin springs back, a clue to hydration.
  • SodiumAlso called Serum sodiumAn electrolyte that controls fluid balance and nerve and muscle signals.
  • Stomach acidAlso called Hydrochloric acid · HCl · Gastric acidThe acid your stomach makes to digest protein and absorb key nutrients.

T

5 entries
  • TelomeresProtective caps on chromosomes that shorten as cells divide and age.
  • TestosteroneThe main male sex hormone, also vital in women, for muscle, libido and energy.Testosterone in women
  • ThiamineAlso called Vitamin B1 · ThiaminVitamin B1, which cells need to turn carbohydrates into energy.
  • TriglyceridesMeasures the main type of fat circulating in your blood.
  • TroponinAlso called Cardiac troponinA heart muscle protein that leaks into the blood when heart cells are damaged.
  • TIBC → see Iron

U

1 entries
  • Urine colorAlso called Pee colorWhat the shade of your urine suggests about hydration and urinary health.

V

6 entries
  • Visceral fatAlso called Intra-abdominal fat · Belly fatDeep belly fat stored around the organs, linked to metabolic health.
  • Vitamin B12Also called Cobalamin · B12A vitamin needed for healthy nerves, red blood cells and DNA.
  • Vitamin CAlso called Ascorbic acidAn antioxidant vitamin needed for collagen, immunity and iron absorption.
  • Vitamin DAlso called 25-hydroxy vitamin D · 25(OH)D · CalcidiolMeasures the main storage form of vitamin D in your blood.Signs of low vitamin D
  • Vitamin KA vitamin the body needs for blood clotting and strong bones.
  • VO2 maxAlso called Maximal oxygen uptakeThe most oxygen your body can use during all-out exercise.

Z

1 entries
  • ZincA mineral essential for immunity, wound healing, taste and hormones.

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About biomarkers & lab tests

How to read your numbers and what to test. Medically reviewed articles carry a review badge and date. How we review.

What’s the difference between functional and conventional ranges?

Functional medicine ranges are the window where the body heals and functions optimally. Your lab’s conventional range is wider and built to flag disease. On DrAxe.com a result outside the functional range shows as “Outside optimal range” in yellow, and a result outside the lab’s range shows in red.

Which blood tests should I ask for?

Beyond a standard panel, the markers that show the most, earliest, are ApoB, hs-CRP, fasting insulin, HbA1c, homocysteine, vitamin D, ferritin and a full thyroid panel (TSH, free T4, free T3 and antibodies). The test lists above group them by question.

How do I read my results?

Upload your bloodwork to see every marker against functional and conventional ranges, with the patterns that connect them, or check one value in the Lab Interpreter.

How often should I retest?

Most people retest after 3 to 6 months of changes to diet, supplements or lifestyle, which is long enough for markers like HbA1c, ferritin and vitamin D to move.

Can a normal result still be a problem?

Yes. A result can sit inside your lab’s range and still be outside the functional range. A vitamin D of 32 ng/mL is inside the lab’s range, yet well below the functional range of 50–80.

Does this page diagnose anything?

No. It explains what each marker measures and what can move it, so you can have a better conversation with your doctor.