Force needed to tear Dupuytren's cords: 0.047 kN vs 0.069 kN
Lab-Made Enzyme Weakens Dupuytren's Hand Cords By 32% In Tissue Testing
A new bacteria-grown enzyme softened the tough collagen cords behind bent, locked fingers in tissue removed during surgery, a step toward a cheaper alternative to the current injection therapy.
- 32% weaker cords
- 6 cords tested
- E. coli-made enzyme
Dr. Axe's Take
This is bench science, not a bedside option yet; six cord samples is a pilot, not proof. Still, it confirms something useful: enzyme-based collagen breakdown already works clinically, via FDA-approved collagenase injection, so this lab-grown version chases a cheaper, more consistent alternative to something already helping hands without surgery. If you have early nodules without a locked finger, I'd address collagen overgrowth directly, daily stretching, manual massage with castor oil to keep tissue pliable, and vitamin C-rich foods supporting normal collagen turnover. For true flexion contracture, talk to a hand surgeon about collagenase injection now rather than waiting on recombinant versions still years away.
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