L-Cysteine: the Antioxidant Amino Acid that Boosts Lung and Brain Function

L-cysteine is used therapeutically and nutritionally to improve the health of humans. It’s a basic building block of glutathione, which has been coined “the mother of all antioxidants.” L-cysteine supplementation, also known as N-acetyl-L-cysteine (NAC), is valued for its ability to increase glutathione levels in the body, which is extremely important for lung function, brain function and liver detoxification. Because a number of health conditions deplete your glutathione levels, you need L-cysteine to make more within your brain and body tissues.

L-cysteine is also valued for its ability to break up mucus, thereby making it easier to cough up phlegm that’s caused by respiratory and pulmonary conditions. Plus, L-cysteine is involved in regulating glutamate levels, influencing the neurons in the central nervous system. (1)

In a nutshell, we all need enough L-cysteine in order to properly fight oxidative stress and conditions affecting the brain and lungs. L-cysteine is made in small amounts by the human body, and you can also get L-cysteine from high-protein foods and supplementation.

What Is L-Cysteine?

L-cysteine is classified as a “semi-essential” amino acid because it can be made in small amounts by the human body, but many people can still benefit from consuming more cysteine from their diets or supplements because of its numerous health benefits. The human body can usually manufacturer L-cysteine from the amino acids serine and methionine, but you need enough folate, vitamin B6 and vitamin B12 for that to be possible.

Along with two other amino acids, glutamine and glycine, L-cysteine is needed to make glutathione, the master antioxidant that’s crucial for your health. L-cysteine is usually the amino acid that’s in shortest supply for making glutamine, so it’s important that you get enough of this amino acid, even though it’s not considered essential.

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Although L-cysteine is a minor scavenger of oxidative stress, its most important role is reviving glutathione, one of the most powerful antioxidants in the body. Longevity researchers believe that glutathione is so pivotal to your health that the level of this antioxidant in your cells may be a predictor for how long you will live. It’s the body’s most important antioxidant because it is within the cell, making it essential for maintaining a healthy immune system and fighting cellular damage. (2)

Health Benefits 

1. Has Antioxidant Properties

L-cysteine works as a scavenger of free radicals that cause cellular damage through oxidative stress, and it improves antioxidant capacity through the preservation of glutathione. This is the most well-known L-cysteine benefit because it can slow down the aging process and help prevent or treat a number of serious health conditions. (3)

This also means that by boosting your levels of glutathione, L-cysteine supports immune function. Research suggests that immunological functions in diseases that are associated with a cysteine and glutathione deficiency may be significantly enhanced and potentially restored by L-cysteine supplementation. (4)

There are studies involving HIV patients that show L-cysteine’s ability to boost your immune system. One study conducted in Europe showed that a formulation including NAC, bovine colostrum, omega-3 fatty acids, and a combination of vitamins and minerals slowed down the decline of immune cells. Another study showed that by replenishing glutathione levels, L-cysteine appears to have a beneficial impact on the immune function of people living with HIV. (5)

L-cysteine supplementation can also improve immune function in postmenopausal women, as indicated by a 2008 study published in Free Radical Biology and Medicine. The study found that a short period of NAC supply, such as two to four months, may lead to prolonged strengthening of immune defense in postmenopausal women.

Researchers concluded that NAC supplementation can contribute to the maintenance of good health and quality of life in postmenopausal women by decreasing the probability of immune system-related diseases (such as infection) as they age. (6)

2. Promotes Detoxification

L-cysteine can be used to help prevent side effects caused by drug reactions and toxic chemicals. According to research published in Alternative Medicine Review, cysteine plays a pivotal role in the detoxification mechanisms in the body. Toxic metals have pro-oxidative effects, and they deplete glutathione levels, so L-cysteine supplements help restore those levels so that you can properly detoxify toxins. (7)

Because L-cysteine helps the body to detoxify dangerous toxins and chemicals, it’s common for doctors to give intravenous NAC to people who are having an acetaminophen overdose in order to prevent or reduce liver and kidney damage. Drug-induced acute liver failure is a fatal disease that’s caused by the toxic metabolite, N-acetyl-p-benzoquinone-imine, that leads to glutathione depletion. When overdose patients are treated with NAC, this allows for a significant increase in glutathione activity. (8)

3. Increases Male Fertility

Because L-cysteine is supplemented to alleviate glutathione depletion during oxidative stress, it’s effective as a treatment of impotence in men who may have poor semen quality, DNA damage and oxidative stress.

A 2016 study published in the International Journal of Fertility and Sterility found that NAC can serve as an effective treatment for male infertility from clinical varicocele, which is when veins become enlarged inside the scrotum. The results of the study showed that sperm concentration improved with the use of NAC. Researchers found that the percentage of clinical pregnancy in the NAC group was 33 percent compared to 10 percent for the control group. (9)

4. Balances Blood Sugar Levels

L-cysteine is beneficial in helping support the body’s natural ability to manage and regulate normal blood sugar levels. A 2009 animal study shows that L-cysteine supplementation may lower glycemia and markers of vascular inflammation in patients with diabetes.

L-cysteine supplementation significantly lowered blood levels of glucose and insulin resistance. There was also a decrease in plasma protein oxidation levels in rats treated with L-cysteine. (10)

5. Supports Digestive Health

L-cysteine improves the body’s digestive capacity because of its ability to slow the aging process. As people age, digestive issues like low stomach acid and gastroenteritis become more prominent. This can be due to the presence of free radicals in the body.

Studies suggest that L-cysteine supplementation can help reduce the symptoms of ulcerative colitis, an inflammatory bowel disease that causes long-lasting inflammation and sores in the digestive tract. Researchers found that a combined therapy of NAC and mesalamine, a conventional medication, produces a clinical improvement of ulcerative colitis symptoms, which is due to a decrease of chemokines that attract white blood cells and produce free radicals. NAC was also found to be safe and well-tolerated. (11)

6. Relieves Symptoms of Respiratory Conditions

NAC works as an expectorant, and it can be used to break down mucus in the body. It helps decrease the severity and frequency of wheezing and respiratory attacks by boosting glutathione and thinning mucus that builds up in the bronchial tubes. This can be helpful when you are suffering from allergy symptoms or you have a respiratory condition like bronchitis or chronic obstructive pulmonary disease (COPD).

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Research published in the International Journal of Chronic Obstructive Pulmonary Disease suggests that L-cysteine supplements can be used to decrease the oxidant burden and inflammation found in patients with COPD, a condition that involves an abnormal inflammatory response in the lungs and restricted airflow that makes it difficult to breathe. NAC has been used by patients to reduce COPD symptoms, exacerbations and the accelerated decline of lung function. (12)

7. Helps Treat Psychiatric Disorders

More and more research has recently suggested that the use of NAC in the treatment of psychiatric illnesses is promising. According to a review published in the Journal of Psychiatry and Neuroscience, many of the disorders that may be benefited from NAC have limited treatment options or suboptimal outcomes with current treatments. Studies suggest that NAC has potential as a treatment for addiction, including marijuana dependence, nicotine addiction, cocaine addiction and even pathological gambling.

A case report suggests that NAC can be used to reduce the symptoms of obsessive-compulsive disorder by improving patients’ control of compulsive washing and obsessional triggers.

Studies have also found that NAC can be useful for people with schizophrenia and manic depression. This is due to the antioxidant activity of NAC, as a growing body of literature suggests that these psychiatric disorders are due in large part to oxidative stress and the disfunction of glutamate metabolism. Glutamate is the most important transmitter for normal brain function, but excessive glutamate may cause toxic damage to the brain. L-cysteine is able to help modulate glutamate levels, thereby helping prevent or treat brain disorders like schizophrenia. (13, 14)

Preliminary studies also show that L-cysteine may be used in preventing or treating the following conditions:

• acne
• angina (restricted blood flow to the heart)
• asthma
• emphysema
• colon cancer
• lung cancer

Related: Allicin: The Beneficial Compound that Makes Garlic So Healthy

Foods

Many high-protein foods contain L-cysteine, although usually in small amounts. These foods include:

• chicken
• turkey
• duck
• pork
• yogurt
• cheese
• eggs
• sunflower seeds
• legumes
• oat bran

Your body manufacturers L-cysteine from the amino acids serine and methionine, but for that to be possible, you need adequate amounts of folate, vitamin B6 and vitamin B12 foods. You can get these vitamins from beans (like chickpeas and pinto beans), lentils, spinach, avocado, bananas, wild-caught salmon and tuna, and liver.

Supplement Dosage

NAC is the form of L-cystine that’s found in nutritional supplements, and it’s been proposed by researchers as a treatment for several illnesses. NAC is used to replenish the intracellular glutathione supply and prevent oxidative damage. It’s also used to inhibit the production of inflammatory cytokines that lead to infection or respiratory conditions. (15)

The following forms of L-cysteine are available:

• NAC aerosol spray — NAC aerosol spray is used for the treatment of respiratory conditions or pulmonary disease. It must be prescribed by a doctor.
• Cysteine/NAC tablets or capsules — Daily NAC tablets or capsules can be used for antioxidant protection and general health.
  • The standard dosage is typically 500 milligrams per day.
  • To treat a respiratory illness, adults can take 200–600 milligrams, twice daily.
  • For COPD, the suggested dose is 600 milligrams, twice daily.
• NAC liquid solution
• NAC topical solution
• L-cysteine powder

Taking a multivitamin or B-complex supplement will ensure that you get the B vitamins that you need when taking NAC. (16)

Risks, Side Effects and Drug Interactions

Very high doses (more than seven grams) of L-cystine can be toxic to human cells, so it’s important to keep track of your doses and take NAC under the guidance of your health care provider, especially if you take it to treat chronic conditions.

NAC supplements should not be taken if you already use medications that suppress the immune system, oxiconazole (an antifungal medication), nitroglycerin and isosorbide (medications for high blood pressure), or activated charcoal.

Some people may experience side effects from L-cysteine supplements, including dry mouth, headache, dizziness, nausea and vomiting. If you experience any of these symptoms, consult your health care provider about changing your dosage or the possibility of allergies.

Final Thoughts

• L-cysteine is valued for its ability to increase glutathione levels in the body, the “mother of antioxidants.” It works as an antioxidant, and it helps boost lung and brain function, and promote liver detoxification.
• L-cysteine is usually the amino acid that’s in shortest supply for making glutamine, so it’s important that you get enough of this amino acid, even though it’s not considered essential.
• Cysteine can be found in high-protein foods like chicken, turkey, beef, duck, yogurt and egg yolks.
• NAC is the form of L-cystine that is found in nutritional supplements, and it has been proposed by researchers as a treatment for several illnesses.
• Very high doses of NAC can be toxic to human cells. Normal doses of NAC (around 500–600 milligrams daily) are generally safe, but side effects may include nausea, vomiting and headache.