33 Dopamine Supplements to Improve Mood and Mental Health

Dopamine supplements are gaining popularity for their ability to enhance focus, motivation, mood and overall cognitive function. Dopamine, often called the “feel-good” neurotransmitter, plays a major role in how we feel pleasure, set goals and stay energized.

In fact, this neurotransmitter is responsible for motivation, focus, mood and the brain’s reward system. As such, when dopamine levels are low, symptoms such as fatigue, lack of motivation and even depression can emerge.

If you’re looking to naturally support your brain’s dopamine production, this guide breaks down the top dopamine supplements to take, who can benefit from them and what to watch out for.

Dopamine supplements

Low dopamine can result in fatigue, apathy, brain fog and even mental health challenges, like depression and ADHD. Luckily, a wide range of natural supplements can help.

These are the best dopamine-boosting supplements backed by science and user experience:

1. L-tyrosine

• Benefit: Precursor to dopamine, supports mental performance under stress.
• Best for: Students, athletes and professionals.

As a precursor to dopamine, L-tyrosine supplementation has been observed to improve cognitive performance and working memory under stress, likely by enhancing dopamine production.

​One randomized, controlled trial investigated the impact of L-tyrosine supplementation on cognitive functions in humans. The research found that individuals with the T/T genotype of the DRD2 gene, which is associated with lower striatal dopamine levels, experienced significant improvements in working memory and inhibitory control after L-tyrosine supplementation.

This suggests that L-tyrosine may enhance dopamine-related cognitive functions, particularly in individuals with genetically lower dopamine levels.

2. Mucuna pruriens

• Benefit: Contains natural L-DOPA, a direct dopamine precursor.
• Best for: Those seeking a fast dopamine boost.

Rich in L-DOPA, a direct dopamine precursor, mucuna pruriens has shown potential in elevating dopamine levels, which may improve symptoms in conditions like Parkinson’s disease.

​A study from 2004 looked at the effects of mucuna pruriens, a natural source of levodopa (L-DOPA), on patients with Parkinson’s disease. The research found that a 30-gram dose of mucuna pruriens led to a faster onset of action and longer duration of therapeutic effects compared to standard L-DOPA/carbidopa medication, without an increase in dyskinesias.

This suggests that mucuna pruriens may effectively boost dopamine levels in humans, offering potential advantages over conventional L-DOPA preparations in managing Parkinson’s disease.

3. Rhodiola rosea

• Benefit: Reduces mental fatigue, may regulate dopamine levels.
• Best for: Stress-related dopamine depletion.

Known for its adaptogenic properties, rhodiola rosea may influence neurotransmitter levels, including dopamine, contributing to reduced stress and improved mood.

​With the intent of examining the effects of rhodiola rosea extract on students experiencing stress during exams, researchers set up a double-blind, placebo-controlled pilot study. The study found that rhodiola rosea significantly improved physical fitness, mental fatigue and neuro-motoric functions.

While the study did not directly measure dopamine levels, the observed enhancements in cognitive and physical performance suggest a potential role of rhodiola rosea in modulating neurotransmitter systems, possibly including dopamine.​

4. Vitamin B6

• Benefit: Essential for converting L-DOPA to dopamine.
• Best for: People with B vitamin deficiencies.

Essential for neurotransmitter synthesis, adequate levels of vitamin B6 are necessary for optimal dopamine production.

​A study dating all the way back to 1978 studied the impact of vitamin B6 (pyridoxine) on hypothalamic dopaminergic pathways by measuring its effect on basal and thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) levels in seven healthy female volunteers. The results indicated that vitamin B6 administration led to a slight reduction in basal and TRH-stimulated PRL levels.

This suggests that vitamin B6 may influence dopamine-mediated hormonal regulation, but the effect appears to be variable and unpredictable.

5. Magnesium

• Benefit: Supports neurotransmitter function and dopamine receptor health.
• Best for: Anxiety-related dopamine imbalance.

This mineral plays a role in neurological function, and its deficiency can impact dopamine receptor function and neurotransmission.

Research has shown that magnesium supplementation may influence the production of cyclic adenosine monophosphate response element-binding protein (CREB) in the brain. CREB regulates genes involved in dopamine production, suggesting that magnesium could play a role in modulating dopamine levels.

6. Ginkgo biloba

• Benefit: Improves blood flow to the brain, may support dopamine activity.
• Best for: Cognitive enhancement and memory.

Supplementation with ginkgo biloba extract has been associated with improved cognitive flexibility, possibly due to enhanced prefrontal cortex dopamine levels.

​For instance, a randomized, double-blind, placebo-controlled trial investigated the effects of ginkgo biloba extract EGb 761® on cognitive control functions in elderly adults with subjective memory impairment. The study found that EGb 761® improved cognitive flexibility and response inhibition, functions associated with prefrontal dopamine activity.

These findings suggest that EGb 761® may enhance prefrontal dopaminergic function, although direct measurements of dopamine levels were not conducted. ​

7. Curcumin (turmeric extract)

• Benefit: Increases dopamine levels and reduces inflammation.
• Best for: Brain fog and mood support.

Curcumin may have neuroprotective effects and could influence neurotransmitter levels, including dopamine.

​In one randomized, double-blind, placebo-controlled study that evaluated the antidepressant effects of curcumin in individuals with major depressive disorder, curcumin supplementation was associated with improvements in depressive symptoms. While the study did not directly measure dopamine levels, the observed antidepressant effects may be related to curcumin’s influence on neurotransmitter systems, including dopamine. ​

8. Phenylalanine

• Benefit: An amino acid precursor to tyrosine and dopamine.
• Best for: Cognitive performance and alertness.

As a precursor to tyrosine, phenylalanine is integral to dopamine synthesis.

​In a study involving patients with phenylketonuria (PKU), researchers examined the impact of elevated blood phenylalanine levels on neurotransmitter synthesis and neuropsychological performance. They found that high phenylalanine concentrations inhibited the formation of dopamine and serotonin, leading to prolonged performance times on neuropsychological tests of higher integrative function.

These effects were reversible upon reducing phenylalanine levels, suggesting that phenylalanine plays a role in modulating dopamine synthesis and associated cognitive functions. ​

9. Omega-3 fatty acids (fish oil)

• Benefit: Supports dopamine receptor sensitivity, enhances dopamine transmission, reduces inflammation in dopamine neurons and supports brain function.
• Best for: Long-term brain health, mood stability and focus.

Rich in omega-3 fatty acids, fish oil supplementation has been associated with improved working memory, potentially linked to dopamine system modulation. These essential fatty acids are crucial for brain health and have been linked to the modulation of dopamine systems, potentially benefiting various neuropsychiatric conditions.

10. N-acetyl L-cysteine (NAC)

• Benefit: Regulates glutamate and increases dopamine in the brain.
• Best for: Mental health support, especially obsessive-compulsive disorder or addiction.

NAC supplementation has been associated with improvements in dopaminergic function, particularly in individuals with Parkinson’s disease. ​

​For example, a randomized, controlled trial analyzed the effects of NAC on the dopaminergic system in Parkinson’s disease patients. Over three months, participants received weekly intravenous infusions (50 mg/kg) and daily oral doses (500 mg twice per day) of NAC.

The study observed significant increases in dopamine transporter binding in the caudate and putamen regions, along with improvements in Parkinson’s disease symptoms. These findings suggest that NAC may enhance dopamine function in humans. ​

11. Ashwagandha

• Benefit: Adaptogen that may help balance dopamine and reduce cortisol.
• Best for: Stress-induced dopamine depletion.

This adaptogen may support neurotransmitter balance, including dopamine, contributing to stress reduction and mood improvement. It’s also been used to help treat Parkinson’s, due to its potential dopaminergic properties.

12. SAM-e (S-adenosylmethionine)

• Benefit: Promotes the synthesis of neurotransmitters, including dopamine.
• Best for: Depression and mood regulation.

SAM-e plays a role in neurotransmitter metabolism and may influence dopamine levels, aiding in mood regulation.

​A clinical study examined the neuroendocrine effects of SAM-e in depressed patients. The researchers observed a significant reduction in prolactin and thyrotropin responses to TRH stimulation in depressed men after SAM-e treatment.

These findings suggest that SAM-e may enhance dopaminergic function, as dopamine inhibits prolactin release. However, the study did not directly measure dopamine levels. ​

13. Green tea extract (L-theanine)

• Benefit: Enhances dopamine levels while promoting calm focus.
• Best for: Anxiety and productivity.

Found in green tea, L-theanine can modulate brain chemicals, including dopamine, promoting a state of relaxed alertness. Research has shown that L-theanine can promote relaxation and reduce stress, effects that may be associated with modulation of neurotransmitter systems, including dopamine.

14. Ginseng

• Benefit: Boosts mental performance and may modulate dopamine activity.
• Best for: Fatigue and mental clarity.

Ginseng has been studied for its potential to enhance cognitive function and may influence dopamine pathways. It’s shown potential dopaminergic effects in scientific studies and is well known for boosting cognitive health.

15. CDP-choline (citicoline)

• Benefit: Enhances dopamine receptor density.
• Best for: Focus and cognitive enhancement.

Citicoline supplementation has been linked to increased dopamine receptor densities, supporting cognitive function.

​A study published in 2009 investigated the effects of citicoline on appetite, food cravings and brain responses to food stimuli in healthy adult women. Participants received either 500 mg/day or 2,000 mg/day of citicoline for six weeks.

The study found that the higher dose group exhibited significant increases in brain responses to food stimuli within the amygdala, insula and lateral orbitofrontal cortex, regions associated with reward and motivation. These findings suggest that citicoline may influence dopaminergic pathways, as dopamine plays a key role in reward processing.

16. Resveratrol

• Benefit: May protect dopamine neurons and promote dopamine production.
• Best for: Anti-aging and brain protection.

This polyphenol may have neuroprotective properties and could influence dopamine signaling pathways. Lab research has studied resveratrol’s neuroprotective effects on dopaminergic neurons, indicating that resveratrol can protect dopamine neurons against various neurotoxic insults.

17. Zinc

• Benefit: Modulates dopamine transmission and brain health.
• Best for: Immune and cognitive function.

Zinc is involved in neurotransmitter function, and its deficiency can affect dopamine metabolism.

A 2017 study noted how zinc influences the monoamine system, including dopamine. The review highlighted that zinc supplementation can augment the efficacy of antidepressants, potentially through interactions with dopamine pathways.

18. Vitamin D

• Benefit: Regulates dopamine synthesis.
• Best for: Seasonal mood disorders and brain function.

Adequate vitamin D levels are important for brain health and may play a role in dopamine synthesis. ​For instance, a study published in 2019 examined the effects of vitamin D3 supplementation on serum dopamine levels in children with ADHD.

The results indicated that serum dopamine levels significantly increased in the vitamin D group compared to the placebo group. However, further research is needed to determine the effects of vitamin D on neurotrophic factors and serotonin. ​

19. Bacopa monnieri

• Benefit: Improves memory and may affect dopamine transport.
• Best for: Students and memory retention.

Traditionally used for cognitive enhancement, bacopa may influence neurotransmitter levels, including dopamine.

​A randomized, double-blind, placebo-controlled trial analyzed the effects of bacopa monnieri on cognitive performance, anxiety and depression in elderly participants. The study found that bacopa supplementation improved memory recall and reduced anxiety and depression scores.

While the study did not directly measure dopamine levels, bacopa’s potential to modulate neurotransmitters, including dopamine, is why many consider it one of the best dopamine supplements.

20. 5-HTP

• Benefit: While more focused on serotonin, it can balance dopamine/serotonin ratios.
• Best for: Emotional balance and sleep support.

While primarily a precursor to serotonin, 5-HTP supplementation can affect the balance of other neurotransmitters, including dopamine.

In a double-blind, placebo-controlled trial, 68 undergraduate participants received either three 50-mg capsules of 5-HTP or placebos, followed by completion of the Tower of London (TOL) task, a test sensitive to changes in forebrain dopamine activity. The results indicated that 5-HTP significantly increased the average time required to complete the TOL trials without affecting accuracy.

The authors concluded that oral administration of 5-HTP disrupts dopaminergic function in the human forebrain, suggesting an interaction between serotonin and dopamine systems.

21. Probiotics

• Benefit: Improve gut-brain axis communication, and the gut produces and regulates neurotransmitters, including dopamine.
• Best for: People with digestive issues, mood imbalances or those looking for a holistic brain-gut dopamine boost.

Emerging research has suggested that gut microbiota can influence brain chemistry, including dopamine production. In fact, certain strains of probiotics (like Lactobacillus plantarum and Bifidobacterium infantis) have been shown to increase dopamine and serotonin levels.

22. Multivitamins

• Benefit: Provide essential co-factors (like B complex, magnesium, zinc and iron) for dopamine synthesis and metabolism, prevents deficiencies that can lower neurotransmitter production.
• Best for: Anyone with a nutrient-poor diet, fatigue or general mood issues.

Comprehensive multivitamins ensure the presence of essential co-factors necessary for dopamine synthesis and function. Research has revealed that these vitamins are vital for amino acid metabolism required for neurotransmitter production, including dopamine.

23. Phenylethylamine (PEA)

• Benefit: Naturally stimulates dopamine and norepinephrine, produces a euphoric “feel-good” sensation.
• Best for: People needing a short burst of motivation or mood elevation.

PEA can promote the release of dopamine, contributing to mood enhancement, as shown in animal models, and experts believe these same effects can benefit humans.

24. Vitamin B5 (pantothenic acid)

• Benefit: Required for the synthesis of coenzyme A, which plays a role in acetylcholine and dopamine production, also helps the adrenal glands regulate stress.
• Best for: Those under chronic stress or adrenal fatigue symptoms.

This vitamin is vital for coenzyme A production, essential in the synthesis and metabolism of dopamine.

25. Vitamin B12

• Benefit: Vital for nervous system function and myelin formation.
• Best for: Vegans, vegetarians, older adults, and people with fatigue or brain fog.

Vitamin B12 plays a role in neurological function, and its deficiency can impact dopamine levels. In fact, low B12 levels are linked to mood disorders and poor dopamine signaling.

26. Folate (vitamin B9)

• Benefit: Supports methylation pathways required for neurotransmitter production (including dopamine, serotonin and norepinephrine).
• Best for: Individuals with MTHFR mutations, depression or prenatal health needs.

Folate is crucial for neurotransmitter synthesis, including dopamine, through its role in one-carbon metabolism and the production of SAM-e, a critical methyl donor. Deficiencies in folate have been associated with neurological issues and mood disorders, suggesting its importance in maintaining healthy neurotransmitter function.

27. Iron

• Benefit: A necessary co-factor in the enzyme tyrosine hydroxylase, which converts tyrosine to L-DOPA (the dopamine precursor).
• Best for: Women (especially menstruating), vegans, and those with anemia or unexplained fatigue.

Iron is a co-factor for tyrosine hydroxylase, the enzyme that converts tyrosine to L-DOPA in dopamine synthesis. Iron deficiency, meanwhile, can impair dopamine synthesis, leading to neurological symptoms.

Addressing iron deficiency through supplementation may help restore normal dopamine production.

28. Caffeine

• Benefit: Blocks adenosine receptors, increasing dopamine availability in key brain regions (like the prefrontal cortex), boosts alertness, focus and mood.
• Best for: Morning fatigue or productivity slumps.

Caffeine can enhance dopamine signaling by antagonizing adenosine receptors, leading to increased alertness.

A study published in Translational Psychiatry sought to determine the impact of caffeine on dopamine receptors. Using positron emission tomography imaging, researchers observed that caffeine intake led to a significant increase in the availability of dopamine D2/D3 receptors in the striatum, a brain region integral to reward and movement.

These findings suggest that caffeine may enhance dopaminergic neurotransmission by increasing the availability of these receptors.

29. Berberine

• Benefit: Activates AMPK pathways, which may influence dopamine sensitivity and brain glucose metabolism.
• Best for: Metabolic health support, insulin resistance and cognitive enhancement.

Berberine may influence neurotransmitter systems, including dopamine, since it activates AMPK pathways.

30. Oregano oil

• Benefit: Contains carvacrol, a compound that may increase dopamine and serotonin in the prefrontal cortex, acts as a natural antimicrobial.
• Best for: Brain health with antimicrobial or gut-cleansing support.

Compounds in oregano oil may have neuroprotective effects and could influence dopamine levels. These compounds, such as carvacrol and thymol, have demonstrated various pharmacological effects, including potential modulation of neurotransmitter systems.

31. Lion’s mane mushroom

• Benefit: Promotes nerve growth factor, enhancing brain plasticity and potentially dopamine system health, may also support mood and memory.
• Best for: Brain regeneration, memory support and neuroinflammation reduction.

This mushroom has been studied for its neurotrophic effects, potentially supporting dopamine-producing neurons. Some research has suggested that lion’s mane mushroom may influence neurotransmitters associated with mood regulation, such as serotonin and dopamine, potentially alleviating symptoms of depression and anxiety.

32. Prebiotics

• Benefit: Feed beneficial gut bacteria, indirectly supporting dopamine production via the gut-brain axis, helps produce short-chain fatty acids that support mental health.
• Best for: People using probiotics or with long-term digestive or mood issues.

By supporting beneficial gut bacteria, prebiotics may indirectly influence dopamine production through the gut-brain axis.

33. L-tryptophan

• Benefit: A precursor to serotonin, it helps balance serotonin-dopamine levels.
• Best for: Individuals with sleep issues, mood swings or low serotonin-related symptoms.

While a precursor to serotonin, L-tryptophan supplementation can affect overall neurotransmitter balance, including dopamine. Stable serotonin can enhance dopamine receptor sensitivity and mood regulation.

Who needs dopamine supplements?

You might benefit from dopamine supplements if you experience:

• Chronic fatigue, apathy or lack of motivation
• Mood disorders, like depression or low-grade anxiety
• Brain fog or poor memory recall
• Difficulty focusing or staying productive
• Cravings or compulsive behaviors
• Addictive behaviors (food, substance use, social media)
• Difficulty with reward-based tasks or goal setting

People at risk of low dopamine levels who could benefit from dopamine supplements include:

• Those with chronic stress
• Individuals with poor diets lacking in amino acids and vitamins
• People with mental health disorders, such as ADHD, depression or Parkinson’s disease
• Long-term stimulant users (caffeine, Adderall, etc.)

Before starting any supplement (including dopamine supplements), it’s wise to consult a healthcare provider, especially if you’re on medication.

Risks, side effects and interactions

While most natural dopamine supplements are considered safe, some can come with side effects, especially if misused or combined with medications.

Common side effects of dopamine supplements include:

• Nausea or digestive upset (e.g., with L-DOPA sources like mucuna pruriens)
• Headaches
• Sleep disturbances (especially stimulatory supplements)
• Overstimulation or anxiety (with high doses of tyrosine or phenylalanine)
• Mood swings

Interactions to watch out for include:

• MAOIs and antidepressants
• Blood pressure medications
• Stimulants (like Adderall, amphetamines or caffeine)

Always start with a low dose, and monitor your body’s response to dopamine supplements.

Tips for safety:

• Start with one supplement at a time.
• Use the lowest effective dose.
• Cycle dopamine supplements (e.g., five days on, two days off).
• Consult your doctor if you’re taking medications.

Conclusion

• Dopamine supplements can be a game-changer for your mood, motivation and mental performance, when used correctly.
• From amino acids like L-tyrosine to adaptogens like rhodiola rosea, the right combination can naturally support your brain’s reward system and keep you sharp and focused.
• However, supplementation should always complement a healthy lifestyle that includes regular exercise, sleep, meaningful goals and a dopamine-smart diet.
• If you suspect low dopamine, a targeted supplement protocol might be your first step toward a clearer, more motivated mind.
• Dopamine supplements can make a huge difference in motivation, mood, focus and even creativity.
• Of course, dopamine supplements are only one piece of the puzzle. Other lifestyle factors and diet play key roles.
• When used wisely and in conjunction with a healthy lifestyle, dopamine supplements can help you feel energized, focused and ready to take on life with purpose.