Supplements · Phospholipids

Sunflower Lecithin: Benefits, Breastfeeding Dose, Choline & Side Effects

What sunflower lecithin is, how much phosphatidylcholine and choline a serving supplies, what the human research shows for plugged milk ducts, blood sugar, memory and liver fat, and how to choose, dose and use it.

Meet the Medical Advisory Board
Evidence-based49 sources citedUpdated October 6, 2026
Published Oct 1, 2026Last updated Oct 6, 2026Editorial policyMedical review policyFact-checking policy
A mound of fine, pale tan lecithin powder on a white surface, with a heaping metal spoonful in front and a round wooden dish behind
Sunflower lecithin is sold as a powder or granules (de-oiled) and as a thick liquid.
The Dr. Axe Score™
6.6/10
Overall Dr. Axe Score · Sunflower Lecithin

Sunflower lecithin earns its score from a well-absorbed form of phosphatidylcholine, a clean safety record at supplement amounts and a guideline use for plugged milk ducts, with encouraging human findings on blood sugar and, from related lecithin products, memory and liver fat.

Scientific Evidence
5.4/10
Two human trials of sunflower lecithin itself; larger randomized trials of soy lecithin and purified phosphatidylcholine; strong composition data.
Bioavailability & Absorption
7.6/10
Phosphatidylcholine delivered as much choline to the blood as choline salts in a study where each person tried both; content varies by grade and is rarely printed on labels.
Clinical Effectiveness
5.6/10
Our judgment: a gentle, soy-free phospholipid source with a guideline use for plugged ducts and encouraging findings on blood sugar, memory and liver fat.
Safety & Tolerability
8.6/10
Few side effects in trials; mild stomach upset reported. Deductions for traces of sunflower protein in allergic people and a phosphorus load in kidney disease.
Why this score?
Why Sunflower Lecithin scores 6.6 / 10
  • How the score works: Scientific Evidence rates the amount and quality of human, animal and lab research; Bioavailability & Absorption rates how well your body takes up and uses what it supplies; Clinical Effectiveness is the team's judgment of real-world usefulness, informed by the cited human studies and Dr. Axe's published teaching on phospholipids; Safety & Tolerability weighs side effects by dose, form and who's taking it. These are editorial judgments, not validated clinical measurements.
  • Interaction check: Low; the sources cited here report no medication interactions, and the details are in the side effects section. Interactions are rated separately and don't change the score.
  • Weighting: Evidence 30% · Bioavailability & Absorption 25% · Clinical Effectiveness 25% · Safety & Tolerability 20% (5.4×0.30 + 7.6×0.25 + 5.6×0.25 + 8.6×0.20 = 6.64, shown as 6.6).
A transparent, weighted index built for supplements. See how it’s calculated →

Interaction check: Low. The safety reviews and trials cited on this page report no medication interactions for lecithin.115

Dr. Josh Axe Vitamin Advisor · 4–5 questions

Which supplements belong in your top 5?

What's your biggest goal right now?

Sunflower lecithin at a glance

Sunflower lecithin is the phospholipid-rich part of sunflower oil, separated out during refining, and it's a soy-free source of phosphatidylcholine, the fat your cell membranes are built from.12 Ten grams of de-oiled powder supplies about 338 milligrams of choline and 270 milligrams of phosphorus.13 For plugged milk ducts, the Academy of Breastfeeding Medicine lists sunflower or soy lecithin at 5 to 10 grams a day.4

  • Blood sugar: in 18 healthy adults, a breakfast with 18 grams of sunflower lecithin produced a 29% smaller blood-sugar rise than the same amount of fat from rapeseed oil5
  • Related research: soy lecithin improved memory scores in adults 65 and older, and a purified phosphatidylcholine lowered liver fat67

Whisk a spoonful of sunflower lecithin into oil and vinegar, and the dressing holds together instead of separating. Lecithin can do that because each of its molecules has two ends, one drawn to water and the other to fat.1 That same two-sided design lets phospholipids line up into the flexible outer wall of every cell in your body.2

In Heal Your Cells, Dr. Will Cole and I call phospholipids the cellular architects, the fats that decide how flexible, strong and communicative your cells are.2 My approach is food first, with supplements to fill the holes in your diet.89 For your cell membranes, the foods I put first are wild salmon, sardines and mackerel, then pasture-raised eggs, whose yolks are rich in phosphatidylcholine, and fish roe.102 After food, I consider phosphatidylcholine and other phospholipid supplements a great way to fill the gap.1011 Sunflower lecithin is a plant-based, soy-free way to add phosphatidylcholine to your day.

Want a step-by-step plan for your cells? Open the free Heal Your Cells protocol (free with your Dr. Axe account, email or Google; you'll also get the protocol's short email series and the Dr. Axe newsletter; unsubscribe anytime).

A lot of people probably aren't familiar with phospholipids, especially phospholipids like phosphatidylcholine. … It's found in egg yolks, it's found in organ meats like liver. These are things in our modern world that almost nobody is getting in their diet. And it's also probably the most critical thing for healing your cell membranes.Dr. Josh Axe, DC, DNM, CNSFrom Functional Medicine Doctor: The Hidden Toxin In Your Home! Why You're Constantly Exhausted (The Dr. Josh Axe Show, 2026), 38:33-38:57

Did you know?

  • No genetically engineered sunflower appears in the international GM crop approval database, while 96% of U.S. soybean acres were planted with herbicide-tolerant varieties in 2024 and 2025.1213

  • In a lab test of peanut butter, adding 2% sunflower lecithin gave the least oil separation and the best taste scores of the versions tested.14

  • Phosphatidylcholine and phosphatidylserine make up large portions of your brain tissue and of the protective myelin sheath around your nerves.2

Advertisement20% off Ancient Nutrition Multi Collagen Protein, code MCP20

What is sunflower lecithin?

Quick answer

Sunflower lecithin is a mix of phospholipids, led by phosphatidylcholine, that's drawn out of crude sunflower oil during refining. It's sold as a thick liquid, which still carries some of the oil, or as de-oiled powder and granules, which concentrate the phosphatidylcholine.1

Soybeans, rapeseed, eggs and sunflower seeds all supply lecithin. Food makers use it as an emulsifier, the ingredient that keeps fat and water blended in chocolate, spreads, dressings and baked goods, and on European labels it's listed as E 322.1

Sunflower lecithin is a soy-free alternative to soy lecithin, which comes from soybean oil and carries traces of soy protein. Sunflower lecithin carries traces of sunflower protein instead, which matters for allergies, covered in the safety section below.16

Is sunflower lecithin a seed oil?

Sunflower lecithin is separated from a seed oil, and the liquid form still carries some of that oil: food-grade liquid lecithin is about 60% phospholipids and 40% oil and other compounds,1 and a teaspoon has about 5 grams of fat.17 The position I take on seed oils is to build your kitchen around whole-food fats like extra virgin olive oil and avocado oil, go easy on heavily refined and deep-fried seed oils, and stop stressing about a little seed oil in an otherwise real-food diet.18 A spoonful of lecithin sits comfortably in that small amount. Refined sunflower oil used for cooking and frying belongs on the go-easy side.

A short history of lecithin

Lecithin's name comes from the food where it was first described: in 1850, the Paris chemist Théodore Gobley named it from the Greek lekithos, egg yolk.19 Twelve years later, in 1862, the chemist Adolph Strecker heated it and obtained a new compound he called choline.19 Researchers later identified lecithin's main component as phosphatidylcholine, one of the main forms of choline in food. Choline itself took more than a century to earn full status: the U.S. Institute of Medicine recognized it as an essential nutrient in 1998, after controlled feeding studies in people.1920

Sunflower lecithin nutrition facts

Quick answer

Ten grams of sunflower lecithin powder (about 1 1/3 tablespoons) has about 80 calories, 5 grams of fat, 1 gram of carbohydrate and 270 milligrams of phosphorus, 22% of the daily value. A teaspoon of liquid lecithin (6 milliliters) has about 50 calories, 5 grams of fat and 152 milligrams of phosphorus.317

Label data from USDA FoodData Central: FDC ID 2417875 (powder) and 2373459 (liquid). Per-serving values are calculated at the label serving; % Daily Value uses FDA label reference values.317

NutrientPowder, 10 gLiquid, 1 teaspoon (6 mL)Powder, per 100 g
Calories8050800
Total fat5 g5 g50 g
Saturated fat1 g0.5 g10 g
Polyunsaturated fat2.5 g3.5 g25 g
Carbohydrate1 g0 g10 g
Protein0 g0 g0 g
Phosphorus270 mg (22% DV)152 mg (12% DV)2,700 mg
Potassium80 mg (2% DV)52 mg (1% DV)800 mg
Calcium25 mg (2% DV)15 mg (1% DV)250 mg
Iron0.3 mg (2% DV)0 mg3 mg

The label's calorie line runs higher than its fat and carbohydrate add up to, so read the calories as approximate.3 Phosphorus stands out: ten grams of powder supplies about a fifth of the daily value, which counts if you have kidney disease and follow a phosphorus limit; our list of foods high in phosphorus puts it in context.

How much choline is in sunflower lecithin?

Choline is a big part of lecithin's appeal, and the amount depends on the grade. Phosphatidylcholine is about 13% choline by weight, so a lecithin's choline tracks its phosphatidylcholine.1 In industry batch data reviewed by the European Food Safety Authority (EFSA), de-oiled sunflower lecithin carried 25% to 28% phosphatidylcholine, more than any soy or rapeseed grade listed.1

Lecithin gradePhosphatidylcholine (% by weight)Choline released (% by weight)Choline per serving (calculated)
Sunflower, de-oiled (powder, granules)25% to 28%3.38% (EFSA's figure for a 25.6% batch)About 338 mg per 10 g
Sunflower, liquid14% to 17%1.89% to 2.27%About 110 to 132 mg per teaspoon
Soy, de-oiled17% to 22%2.22% to 2.93%About 222 to 293 mg per 10 g
Soy, liquid13% to 17%1.67% to 2.20%About 97 to 128 mg per teaspoon

Phosphatidylcholine and choline percentages from EFSA's industry composition data; servings calculated by us (for example, 10,000 mg × 3.38% = 338 mg), with the label's 1-teaspoon (6 mL) serving of liquid lecithin weighing about 5.8 grams. These describe typical batches rather than a lab test of any one product.1

Against the adequate intake of 550 milligrams a day for men and 425 for women, 10 grams of de-oiled sunflower lecithin covers about 61% and 80%. Nursing mothers need 550 milligrams a day, and pregnant women 450.2122 In national survey data, only 8.03% of U.S. adults reached the adequate intake, and people who ate eggs took in far more choline than people who didn't, 525 versus 294 milligrams a day.22

Choline per serving: sunflower lecithin, beef liver and eggs

Choline per serving: sunflower lecithin, beef liver and eggsCalculated from EFSA composition data and USDA FoodData Central · milligrams of choline per serving. Sunflower lecithin, de-oiled powder (10 g): 338 mg choline; Beef liver (3 oz): 283 mg choline; Egg (1 large): 147 mg choline; Sunflower lecithin, liquid (1 teaspoon; 110 to 132 mg): 110 mg cholineCalculated from EFSA composition data and USDA FoodDataCentral · milligrams of choline per servingSunflowerlecithin,de-oiled powder(10 g)338 mg cholineBeef liver (3oz)283 mg cholineEgg (1 large)147 mg cholineSunflowerlecithin, liquid(1 teaspoon; 110to 132 mg)110 mg choline
Source: EFSA, 2017 · USDA FoodData Central [1]Choline per serving. The lecithin values are calculated from typical batch composition, and the liquid bar shows the low end of its 110 to 132 mg range.

Gram for gram, de-oiled lecithin is a concentrated source. The foods bring more along with their choline: 3 ounces of beef liver supplies about 283 milligrams with a long list of B vitamins and minerals, and a large egg supplies 147 milligrams with protein, vitamin B12 and selenium.232425 Among whole foods, choline runs highest in beef liver and egg yolks,11 and pasture-raised whole eggs, yolk included, are among the desert island food picks in The Biblio Diet.25

What is sunflower lecithin good for?

Quick answer

Sunflower lecithin's best-known use is for plugged milk ducts, where a breastfeeding medicine guideline recommends it, and in a trial of sunflower lecithin itself, a lecithin breakfast blunted the rise in blood sugar and insulin.45 Trials of closely related products, soy lecithin and purified phosphatidylcholine, found better memory scores in older adults and less liver fat.67

Where the research stands

We found two human trials of sunflower lecithin itself: a single-breakfast trial in 18 adults and a 90-day dry eye trial that enrolled 31 (20 finished).526 The larger trials used soy lecithin or purified phosphatidylcholine, which deliver the same main phospholipid, so the product studied is named in every result below.6277

Sunflower lecithin benefits, graded by evidence (updated September 2026). Evidence labels are editorial judgments that compare these uses with each other; they aren't formal certainty ratings.
UseEvidenceProduct studiedWhat the research shows

After-meal blood sugar

Emerging

Enriched sunflower lecithin, 18 g in one breakfast

29% smaller blood-sugar rise and 32% smaller insulin rise than the same fat from rapeseed oil5

Plugged milk ducts

Emerging

Sunflower or soy lecithin, by mouth

Listed by the Academy of Breastfeeding Medicine to reduce duct inflammation and emulsify milk4

Memory, adults 65 and older

Emerging

Soy lecithin, 2.4 or 4.8 g a day, 24 weeks

Memory-test scores improved on both doses; placebo dipped slightly6

Liver fat

Emerging

Purified soybean phosphatidylcholine (essential phospholipids), 1.8 g a day, 6 months

Liver fat fell 24.6 vs. 9.8 dB/m on placebo7

Energy and blood pressure

Mixed

Soy lecithin, 1.2 g a day, 8 weeks

Vigor up and diastolic blood pressure down 4.1 mmHg; the main fatigue score improved in every group27

Dry eye

Mixed

Sunflower lecithin, 4.8 g a day, vs. olive oil, 90 days

Symptom scores fell 3.21 vs. 1.50 points, not a significant difference26

Ulcerative colitis

Mixed

Delayed-release soy phosphatidylcholine

50% vs. 10% improved in an early trial and disease activity dropped 51.7% vs. 33.3% at 3.2 g in a 156-patient trial; two later trials found no difference from placebo282930

Cholesterol

Mixed

Soy lecithin, 0.5 to 20 g a day

HDL-to-LDL ratio rose in one trial; a fat-matched trial found no change3132

How sunflower lecithin works in your body

Sunflower lecithin does three jobs: its phospholipids become part of your cell membranes, its phosphatidylcholine supplies choline, and its two-sided molecules keep fat and water mixed.

  • Builds cell membranes. Phospholipids such as phosphatidylcholine form the double layer of every cell membrane. As Heal Your Cells puts it, "Without enough phospholipids, your cells quite literally lose their shape."2 Researchers propose that extra phospholipids from food or supplements support membrane repair; the lecithin trials didn't measure membranes directly.

  • Supplies choline. Your body frees choline from phosphatidylcholine and uses it to make acetylcholine, a messenger for memory and muscle control, and betaine, which helps recycle homocysteine through methylation.20 In a study where six healthy men tried each form in turn, egg phosphatidylcholine raised blood choline as much as the same dose of choline salts, peaking later, at about three hours.33

  • Keeps fat and water mixed. Lecithin's emulsifying action is well established in food.1 In the breast, researchers propose it keeps milk fat emulsified and calms inflammation in narrowed ducts; the breastfeeding section below covers what's been measured.4

Sunflower lecithin benefits, ranked by evidence

Ranked by the strength of the human research and clinical guidance behind each use, sunflower lecithin's benefits start with after-meal blood sugar and plugged milk ducts, where a breastfeeding guideline recommends it, followed by findings from related lecithin products on memory, liver fat, energy and blood pressure, and mixed results for dry eye and ulcerative colitis.

1

After-meal blood sugar and appetite hormones

Emerging evidenceHuman studyRandomized crossover · 18 adults · one breakfast

In a Swedish trial, 18 healthy young adults ate white bread on four separate mornings: with 18 grams of an enriched sunflower lecithin (83% polar lipids, a larger amount than a typical serving), with the same amount of fat as rapeseed oil, with oat polar lipids, or plain. The lecithin breakfast produced a 29% smaller rise in blood sugar over the next two hours than rapeseed oil (103.1 versus 145.1 mmol·min/L) and a 32% smaller rise in insulin. Compared with rapeseed oil, it also raised the fullness hormones GLP-1 (about 27% more) and PYY (about 37% more) and lowered the hunger hormone ghrelin (about 27% less), and it beat plain bread on all three; the oat lipids did about as well.5 Insulin stayed lower after lunch too, while lunchtime blood sugar didn't differ significantly from the rapeseed-oil morning. For the bigger picture, see the insulin resistance diet.

Study takeaway: a sunflower lecithin breakfast produced a 29% smaller blood-sugar rise than the same fat from rapeseed oil.

Blood-sugar rise after breakfast: 29% smaller with sunflower lecithin

Blood-sugar rise after breakfast: 29% smaller with sunflower lecithin18 healthy young adults · one breakfast each · blood sugar over the next two hours. Bread with sunflower lecithin (18 g): 103.1 mmol·min/L; Bread with rapeseed oil (18 g): 145.1 mmol·min/L18 healthy young adults · one breakfast each · blood sugarover the next two hours103.1BREAD WITHSUNFLOWERLECITHIN (18G)145.1BREAD WITHRAPESEED OIL(18 G)mmol·min/L
Source: Hossain et al. · Frontiers in Nutrition, 2024 [5]Area under the blood-sugar curve for two hours after each breakfast. A lower bar means a smaller rise.
2

Plugged milk ducts

Emerging evidenceClinical guideline · lab study

The Academy of Breastfeeding Medicine lists sunflower or soy lecithin for plugged ducts; the breastfeeding section covers the dose, how it's thought to work and how to use it.4

Study takeaway: a breastfeeding medicine guideline recommends it for plugged ducts.

3

Memory and thinking in older adults

Emerging evidenceHuman studyRCT · 300 adults 65 and older · soy lecithin

In a placebo-controlled trial in China, 300 adults 65 and older, some with mild memory problems or muscle loss, took 2.4 or 4.8 grams of soy lecithin a day or a placebo for 24 weeks. Scores on the MoCA, a standard test of memory and thinking, improved on both lecithin doses while the placebo group's dipped slightly. Blood levels of irisin, a hormone muscles release, rose on both doses, muscle mass didn't differ, and the maker supplied the tablets.6 An older Cochrane review of 12 lecithin trials found no clear benefit in Alzheimer's disease or Parkinson's-related dementia, and a large benefit in one trial of people with memory complaints.34 Our guide to improving memory covers the daily habits that support it.

Study takeaway: soy lecithin improved memory-test scores over 24 weeks in adults 65 and older.

4

Less liver fat

Emerging evidenceHuman studyRCT · 193 adults · purified phosphatidylcholine

In a trial run at several hospitals, 193 adults (165 analyzed) with fatty liver plus type 2 diabetes, high blood fats or obesity took 1.8 grams a day of essential phospholipids, a purified soybean extract that's mostly phosphatidylcholine, or a placebo for six months, on top of their usual care. On a scan-based measure of liver fat, levels fell 24.6 dB/m versus 9.8 on placebo. The drop was already significant at three months and held three months after people stopped, and HbA1c and fatigue improved too; the product's maker funded the trial.7 As I've explained on my show, choline and phosphatidylcholine support bile production and fat transport, which matters for the cells of your liver.35

Study takeaway: purified phosphatidylcholine lowered liver fat more than placebo over six months.

5

Energy and blood pressure

Mixed evidenceHuman studyRCT · 96 women aged 40 to 60 · soy lecithin

In 96 women aged 40 to 60 with fatigue, 1,200 milligrams of soy lecithin a day for eight weeks raised vigor scores (+1.9 versus +0.2 on placebo) and lowered diastolic blood pressure (−4.1 versus +1.2 mmHg), and an arterial stiffness score improved; the main fatigue score improved about equally in every group, placebo included.27 The product's maker funded the study. A draft monograph from Europe's herbal medicines committee also lists soybean lecithin, 1.5 to 8.1 grams a day, as a traditional remedy for temporary fatigue and weakness.1 See natural ways to lower blood pressure for the rest of the plan.

Study takeaway: soy lecithin raised vigor scores and lowered diastolic blood pressure by 4.1 mmHg.

6

Dry eye

Mixed evidenceHuman studyRCT · 31 enrolled, 20 finished · sunflower lecithin

In a 90-day placebo-controlled trial, 31 adults with dry eye from blocked oil glands in the eyelids were assigned 4,800 milligrams of sunflower lecithin or an olive oil placebo (4,000 milligrams a day), and 20 finished. Among them, symptom scores fell about twice as much on lecithin (3.21 versus 1.50 points), a difference that wasn't statistically significant, and tear stability, gland scores and an inflammation marker improved in both groups.26

Study takeaway: symptom scores fell 3.21 points on sunflower lecithin and 1.50 on olive oil.

7

Ulcerative colitis

Mixed evidenceHuman study4 RCTs · delayed-release soy phosphatidylcholine

A delayed-release soy phosphatidylcholine designed to open in the colon helped in two early trials: in 60 adults whose colitis hadn't responded to steroids, 2 grams a day for 12 weeks let 50% of patients, versus 10% on placebo, come off steroids while in remission or clearly improved,28 and in 156 patients, disease-activity scores dropped 51.7% on 3.2 grams a day versus 33.3% on placebo.29 Two later trials of the product from the 156-patient trial, with 466 and 150 patients, found no difference from placebo.30

Study takeaway: two earlier trials were positive, the second at its top dose; two later trials found no difference from placebo.

Get the free Heal Your Cells protocol

Phospholipids are one piece of rebuilding your cells. This free 90-day protocol, from the book by Dr. Axe and Dr. Will Cole, puts the pieces in order:

  • Four phases, in order
  • The cellular nutrients that work, ranked
  • The foods that feed your mitochondria, plus a 7-day meal plan
  • How to test, ranked

Free with your Dr. Axe account (email or Google). You'll also get the protocol's short email series and the Dr. Axe newsletter; unsubscribe anytime.

Open the free protocol → →

Sunflower lecithin for breastfeeding and plugged ducts

Quick answer

Sunflower lecithin is one of the options for plugged milk ducts: the Academy of Breastfeeding Medicine's 2022 protocol lists sunflower or soy lecithin, 5 to 10 grams a day by mouth, to reduce inflammation in the ducts and emulsify milk.4 LactMed, the NIH's database on drugs and breastfeeding, notes that lecithin is usually well tolerated and is considered generally recognized as safe (GRAS) as a food ingredient.15

A plugged duct usually shows up as a tender, firm spot in the breast. The 2022 protocol describes it as ductal narrowing: inflammation and swelling squeeze the milk duct.4 The protocol's reasoning is that lecithin calms that inflammation and keeps milk fat flowing. The recommendation comes from lactation specialists' experience and lab work.415

The lab work shows the emulsifying effect clearly. When researchers pumped donated breast milk from six mothers through feeding tubes, 58% of the milk fat was lost in the pump system without lecithin, compared with 2% when they added 1 gram of soy lecithin per 50 milliliters of milk.36 Because the lecithin went straight into the collected milk, the study shows the emulsifying effect, not what happens after a mother takes lecithin by mouth.

Milk fat lost to feeding tubes: 58% without lecithin, 2% with it

Milk fat lost to feeding tubes: 58% without lecithin, 2% with itDonated breast milk from six mothers · lab study · 1 g soy lecithin per 50 mL. Milk with soy lecithin: 2 % of milk fat lost; Milk without lecithin: 58 % of milk fat lostDonated breast milk from six mothers · lab study · 1 g soylecithin per 50 mL2MILK WITH SOYLECITHIN58MILK WITHOUTLECITHIN% of milk fat lost
Source: Chan et al. · J Pediatr Gastroenterol Nutr, 2003 [36]Share of milk fat lost as donated breast milk was pumped through feeding tubes. A lower bar means less fat lost.

To reach the protocol's amount, remember that 10 grams of powder is about 1 1/3 tablespoons by label weight; check the grams per scoop, and with capsules check the milligrams, since reaching 5 grams takes several.3 Taking it with meals and splitting the amount across the day is an easy way to start. The same protocol also lists oral lecithin among the options for a milk bleb, a small, painful blister on the nipple.4

Lecithin feeds your breast milk in another way, through choline. Phosphatidylcholine and the other building blocks of lecithin are normal components of human milk, and LactMed notes that most nursing mothers don't reach adequate choline intake.15 In 103 women from a pregnancy trial, a phosphatidylcholine supplement taken from 18 weeks of pregnancy until 45 days after birth raised choline and related compounds in their breast milk.37 The full trial enrolled 140 women, and the supplement didn't change their babies' development scores at 10 and 12 months.38

Call your doctor if you develop a fever, chills or a hot, red, spreading area on the breast. Those signs can mean mastitis that needs treatment.4

Bloodwork that shows how your cells are fed

These markers show where your cells stand, though none measures lecithin itself. Your practitioner can read them against your targets.

  • Omega-3 Index: The share of EPA and DHA in your red blood cell membranes, a direct look at the fats your membranes are built from.
  • Homocysteine: An amino acid your body recycles through methylation, a pathway that runs on folate, B12 and betaine made from choline.20
  • HbA1c: Your average blood sugar over about three months.

See the cellular bloodwork panel

Have results? Analyze them free → →

Does sunflower lecithin lower cholesterol or affect heart health?

Quick answer

In one trial, soy lecithin raised the HDL-to-LDL ratio in postmenopausal women, and phosphatidylcholine, the main phospholipid in lecithin, didn't raise the heart-risk marker TMAO in controlled studies.313940 A trial that matched the fat between groups found no change in cholesterol on 20 grams of soy lecithin a day.32

The cholesterol research on lecithin comes from trials of soy lecithin. In 25 healthy postmenopausal women (22 finished), 20 grams of soy lecithin a day for four weeks raised the HDL-to-LDL ratio from 0.49 to 0.65, measured against where they started.31 In a study of 30 older adults with high cholesterol, the 20 who took one 500-milligram soy lecithin capsule a day for two months had about 42% lower total cholesterol and 56% lower LDL than at the start; their HDL fell too, and the paper didn't compare the groups directly.41

A trial that matched the fat between groups found no cholesterol change. In 20 men with high blood fats, 20 grams of soy lecithin a day for four weeks left total, LDL and HDL cholesterol, triglycerides and other markers unchanged, compared with a group given the same calories and linoleic acid from sunflower oil.32 If cholesterol is your main goal, use lecithin as one piece of a bigger plan and start with these ways to lower cholesterol naturally.

Does lecithin raise TMAO?

In controlled trials, phosphatidylcholine, the form of choline in lecithin, didn't raise TMAO the way choline salts did.3940 TMAO is a compound your gut bacteria and liver make from choline. In an observational study of 4,007 heart patients, those with the highest levels had more heart attacks, strokes and deaths over three years, and in healthy volunteers, two eggs plus labeled phosphatidylcholine raised TMAO.42

Where the choline in lecithin goes

1Phosphatidylcholine → choline

Your body frees choline from the phosphatidylcholine in lecithin and egg yolks.2033

2Choline → acetylcholine

Nerve cells use choline to make acetylcholine, a messenger for memory and muscle control.20

3Choline → betaine → homocysteine recycled

Your liver turns choline into betaine, which recycles homocysteine back into the amino acid methionine through methylation.20

4Choline → TMA → TMAO

Gut bacteria can turn choline into TMA, which your liver makes into TMAO. How much depends on the form of choline, as the trials below show.3942

The form of choline makes a difference. In a trial where 37 healthy men tried each form of choline in turn, 600 milligrams of choline as choline bitartrate produced a threefold greater TMAO response, while the same choline as phosphatidylcholine didn't raise TMAO compared with a choline-free meal.39 A Cleveland Clinic trial found the same pattern over four weeks: phosphatidylcholine supplements didn't raise TMAO or make platelets stickier, while choline bitartrate did.40 Choline from phosphatidylcholine, the form in lecithin and egg yolks, behaves differently in your gut than choline salts.33

Sunflower lecithin vs. soy lecithin vs. egg lecithin

All three supply phosphatidylcholine. Of the three, sunflower lecithin is the one that's both plant-based and soy-free.

Sunflower lecithinSoy lecithinEgg lecithin

Source

Sunflower seed oil

Soybean oil

Egg yolk

Phosphatidylcholine

14% to 17% liquid; 25% to 28% de-oiled1

13% to 17% liquid; 17% to 22% de-oiled1

Varies by product

Leftover protein

414 to 892 mg per kg, from sunflower16

232 to 1,338 mg per kg in standard grades, from soy16

About 50 mg per kg, from egg16

Genetically engineered crop

No GE sunflower listed12

96% of U.S. soybean acres herbicide-tolerant13

Not applicable

Plant-based

Yes

Yes

No

Liquid, powder, granules or capsules?

The form decides how much phosphatidylcholine you get per spoonful and how you'll use it.

Liquid

Thick and oily, 14% to 17% phosphatidylcholine; blends into smoothies and dressings. A label teaspoon (6 mL) weighs about 5.8 grams.117

Powder

De-oiled, 25% to 28% phosphatidylcholine; mixes into drinks and batters.1

Granules

De-oiled lecithin in small beads that sprinkle easily; grams per spoonful vary by product, so check the label.

Capsules and softgels

Convenient for small amounts. Check the milligrams per capsule, since larger daily amounts take several.

Labels rarely list phosphatidylcholine, so use this checklist when you buy:

  • Grade stated, liquid or de-oiled, with grams per serving

  • Phosphatidylcholine listed as a percentage or in milligrams, when the maker provides it

  • Extraction stated, such as expeller- or cold-pressed, if you'd rather avoid solvent-extracted oil

  • Third-party tested for identity and contaminants

  • Stored sealed and cool, following the label's storage directions once opened

Want help fitting sunflower lecithin into your routine?

Ask Dr. Axe AI. Answers are grounded in this library, with sources shown.

How much sunflower lecithin should you take a day?

Quick answer

There's no established daily dose for general use; the one guideline amount is 5 to 10 grams a day for plugged milk ducts.4 In longer trials, people took 1.2 to 4.8 grams a day of soy or sunflower lecithin for eight to 24 weeks, or 1.8 grams a day of a purified phosphatidylcholine for six months.276267

GoalForm studiedDaily amountHow long

Plugged milk ducts

Sunflower or soy lecithin

5 to 10 g

Guideline amount4

After-meal blood sugar

Enriched sunflower lecithin

18 g in one meal

One breakfast5

Memory, adults 65 and older

Soy lecithin tablets

2.4 or 4.8 g

24 weeks6

Energy and blood pressure

Soy lecithin tablets

1.2 g

8 weeks27

Liver fat

Purified soybean phosphatidylcholine

1.8 g

6 months7

Dry eye

Sunflower lecithin

4.8 g

90 days26

The table shows what the trials used. For everyday use, think in food amounts. A teaspoon of powder is about 2.5 grams, inside the range the longer trials used, and a teaspoon of liquid is about 5.8 grams. Taking it with a meal is an easy way to help avoid stomach upset, the main side effect reported.1317

How to use sunflower lecithin in food

In your kitchen, sunflower lecithin does the same job it does in packaged foods: it keeps fat and liquid blended. It doesn't thicken; for that, see our guide to xanthan gum.

Blend it into a smoothie with nut butter or coconut milk; see healthy smoothie recipes.
Whisk it into a homemade vinaigrette so the oil and vinegar hold together.
Stir it into natural nut or seed butter to keep the oil from pooling on top.
Bake with it by adding a small amount to bread or muffin batter as an emulsifier.
Froth it into cocoa or coffee with a spoonful of coconut oil for a creamier cup.
Make chocolate or fudge at home, the same job lecithin does in store-bought chocolate.

On skin, lecithin is a common cream ingredient. A cosmetic safety panel judged it safe as used at up to 50% concentration, and noted that phospholipids applied to skin don't reproduce the effects they have inside the body.43

Sunflower lecithin side effects & who should be careful

Quick answer

Sunflower lecithin is well tolerated at supplement amounts; the side effects reported are mild stomach upset, loose stools and diarrhea.115 EFSA found no safety concern at the amounts used as a food additive, including for infants from 12 weeks to 11 months, and saw no need for a numerical intake limit.1 Be careful with a sunflower seed allergy and with kidney disease that calls for a phosphorus limit.

In the trials, side effects were few: the fatigue trial reported none linked to lecithin, and the liver-fat trial found no safety concerns.277

  • Sunflower seed allergy. Sunflower lecithin carries traces of sunflower seed protein, 414 to 892 milligrams per kilogram in two commercial samples, too little to register on a nutrition label and enough to matter if you're allergic.161 In 72 children given sunflower seed in supervised challenges at an allergy center, 60 had no reaction and 10 reacted, 4 of them severely enough to need epinephrine; in the wider group of 230 children advised to avoid sunflower seed, all but one had another food allergy, most often tree nuts, sesame or peanut.44 If you're allergic to sunflower seeds, skip sunflower lecithin, and don't try it at home to see; decide with your allergist.

  • Soy allergy. Sunflower lecithin is made from sunflower, not soy, so it doesn't carry the leftover soy protein that antibodies from soy-allergic patients bound in lab tests of soy lecithin.4546 Check the finished product's allergen statement.

  • Kidney disease with a phosphorus limit. Ten grams of powder carries 270 milligrams of phosphorus, so count it toward your limit or skip it.3

  • Pregnancy. Choline needs rise to 450 milligrams a day, and phosphatidylcholine supplements taken from 18 weeks of pregnancy were well tolerated in a trial.2138 If you add lecithin during pregnancy, confirm the dose with your OB.

  • Stomach upset. Stomach pain, loose stools and diarrhea have been reported, in one report at 1.5 to 2.7 grams a day of a high-phosphatidylcholine lecithin.1 Start low and take it with food.

Is sunflower lecithin hard on your gut lining?

The research so far is reassuring: in a lab model of human gut bacteria, lecithin didn't cause the damage seen with two other emulsifiers, and in a four-week human trial, soy lecithin didn't raise gut or blood inflammation markers.4748 Some food emulsifiers have earned a bad reputation, so it's worth knowing where lecithin stands. On my list of additives to leave on the shelf, the emulsifiers are carboxymethylcellulose (CMC) and polysorbate 80 (P80).25 When researchers exposed human gut bacteria to 20 emulsifiers in a lab model, CMC and polysorbate 80 caused lasting harm, while lecithin didn't significantly change the bacteria.47 One 2026 lab and mouse study found that soy lecithin, at doses matched to daily exposure, weakened the gut-lining barrier and raised allergy antibodies in mice; it didn't test sunflower lecithin.49

In a 2026 trial, 60 healthy adults ate foods made with one of five emulsifiers, or none, for four weeks; soy lecithin didn't raise fecal calprotectin, a gut inflammation marker, or CRP in the blood compared with the group that got no additive. Short-chain fatty acids, the helpful fats gut bacteria make, ran lower across the emulsifier groups than with no additive, most clearly with CMC.48 Keep reading labels for CMC and P80, and if your gut lining needs repair, start with the leaky gut guide.

The bottom line

Is sunflower lecithin worth taking?

For many people, yes. Sunflower lecithin is a gentle, soy-free way to add phosphatidylcholine, the phospholipid your cell membranes are built from, and it's a guideline option for nursing mothers with plugged ducts. It works best on top of the foods that build membranes: fatty fish, pasture-raised egg yolks, liver and fish roe, starting with the egg yolk where lecithin was first described in 1850. The plugged-duct use has a breastfeeding guideline behind it, and the amount of choline it supplies is well measured; the blood-sugar, memory and liver-fat findings are promising, and most come from soy lecithin or purified phosphatidylcholine.

For plugged ducts, the breastfeeding guideline amount is 5 to 10 grams a day. For everyday use, a teaspoon of powder (about 2.5 grams) with a meal sits inside the 1.2 to 4.8 grams a day used in the longer trials. Give your cells good raw materials, and trust the body that was designed to heal.

Get the free Heal Your Cells protocol

Four phases in order, the cellular nutrients that work ranked, the foods that feed your mitochondria and a 7-day meal plan. Free with your Dr. Axe account (email or Google). You'll also get the protocol's short email series and the Dr. Axe newsletter; unsubscribe anytime. Have recent bloodwork? Analyze it free.

Open the free protocol → →

Sunflower lecithin: frequently asked questions

Is sunflower lecithin good for you?

Yes. It's a gentle, soy-free source of phosphatidylcholine, the phospholipid your cell membranes are built from.21 A breastfeeding guideline lists it for plugged ducts, and a breakfast made with it blunted the rise in blood sugar and insulin.45

Does sunflower lecithin help clogged milk ducts?

It's a recommended option. The Academy of Breastfeeding Medicine lists sunflower or soy lecithin, 5 to 10 grams a day, to reduce inflammation in narrowed ducts and emulsify milk.4 Know the signs that mean you should call your doctor.

How much sunflower lecithin should I take for a clogged duct?

The guideline amount is 5 to 10 grams a day by mouth.4 By label weight, 10 grams of powder is about 1 1/3 tablespoons, so check the grams per scoop or capsule on your product.3

Does sunflower lecithin affect milk supply?

No study has measured whether it raises or lowers milk supply; its guideline use, at 5 to 10 grams a day, is for narrowed ducts.4 What has been measured is the milk itself: in 103 women, a phosphatidylcholine supplement taken from 18 weeks of pregnancy until 45 days after birth raised choline and related compounds in their breast milk.37

Does sunflower lecithin have choline?

Yes. Its phosphatidylcholine releases choline: about 338 milligrams in 10 grams of de-oiled powder and about 110 to 132 milligrams in a label teaspoon (6 milliliters) of liquid.117 Ten grams of powder covers about 61% of the 550-milligram adequate intake for men and 80% of the 425 milligrams for women.21

Is sunflower lecithin better than soy lecithin?

The main difference is soy: sunflower lecithin has no soy protein and comes from a crop with no genetically engineered varieties listed.1612 De-oiled sunflower lecithin also carried more phosphatidylcholine than de-oiled soy lecithin in EFSA's batch data.1

Sunflower lecithin or phosphatidylcholine: what's the difference?

Sunflower lecithin is a food-grade mix of phospholipids that's about 14% to 28% phosphatidylcholine by weight, depending on the grade.1 A purified phosphatidylcholine supplement is mostly phosphatidylcholine: the liver-fat trial used one at 1.8 grams a day for six months, while the breastfeeding guideline uses lecithin at 5 to 10 grams a day.74

Does sunflower lecithin lower cholesterol?

The closely related soy lecithin improved the balance in one trial: the HDL-to-LDL ratio rose from 0.49 to 0.65 in postmenopausal women.31 A trial in 20 men with high blood fats found no change on 20 grams a day, compared with a group given the same fat from sunflower oil.32

Does sunflower lecithin help memory?

The closely related soy lecithin did in a trial of 300 adults 65 and older: 2.4 or 4.8 grams a day for 24 weeks improved memory-test scores compared with placebo.6 In people with dementia, older lecithin trials found no clear benefit, while one trial in people with memory complaints found a large benefit.34

What are the side effects of sunflower lecithin?

Side effects are uncommon and mild: stomach upset, loose stools or diarrhea, reported at 1.5 to 2.7 grams a day of a high-phosphatidylcholine lecithin.1 Skip it with a sunflower seed allergy, and count its phosphorus (270 milligrams per 10 grams of powder) if you follow a kidney-related phosphorus limit.3

Can you take too much sunflower lecithin?

Taking more mainly raises the chance of stomach upset and loose stools.1 No maximum dose has been set for lecithin itself; the adult upper limit of 3,500 milligrams a day applies to choline from all food and supplements combined.21

When is the best time to take sunflower lecithin?

With a meal. In the one trial of sunflower lecithin at a meal, 18 grams in a breakfast blunted that meal's rise in blood sugar and insulin, and in a study where each person tried both forms, phosphatidylcholine raised blood choline gradually, peaking at about three hours.533 For plugged ducts, splitting the guideline's 5 to 10 grams across your meals makes the amount easier to reach.4

Is sunflower lecithin safe during pregnancy?

Phosphatidylcholine supplements taken from 18 weeks of pregnancy were well tolerated in a trial, and choline needs rise to 450 milligrams a day in pregnancy.3821 If you add lecithin, confirm the dose with your OB.

Is sunflower lecithin safe if I'm allergic to soy?

It's made from sunflower, not soy, so it doesn't carry the soy protein found in soy lecithin; check the product's allergen statement to be sure.16 Sunflower seed allergy is a separate matter: sunflower lecithin carries traces of sunflower protein, 414 to 892 milligrams per kilogram in two commercial samples, so skip it if you're allergic to sunflower seeds.16

Is sunflower lecithin GMO?

No genetically engineered sunflower appears in the international GM crop approval database.12 For extra assurance, choose a product labeled organic or non-GMO; see the real risks of GMO foods.

What is sunflower lecithin used for in food?

It's an emulsifier that keeps oil and water blended in chocolate, dressings, spreads and baked goods, and at home it works in smoothies, vinaigrettes and nut butters.1 In a lab test of peanut butter, adding 2% sunflower lecithin gave the least oil separation of the versions tested.14

Freshness & update log

October 6, 2026 — Matched Dr. Axe's quotes to his own words, with their sources.

September 30, 2026 — Rewrote the page in full. Added the Dr. Axe Score under the current supplement weighting (editorial score 6.6) with an Interaction check; added the Academy of Breastfeeding Medicine's 5- to 10-gram recommendation for plugged ducts and LactMed's guidance; added the human trials of sunflower lecithin itself (after-meal blood sugar, dry eye) and related trials of soy lecithin and phosphatidylcholine (memory in older adults, fatigue and blood pressure, liver fat, TMAO); quantified phosphatidylcholine and choline by lecithin grade; re-sourced the brain, breastfeeding, cholesterol and digestive claims to studies that tested lecithin, including the controlled cholesterol trials; removed the eczema claim, whose cited studies tested other creams; corrected "non-allergenic" (sunflower lecithin carries traces of sunflower protein); and removed an unsourced daily maximum and history.

September 30, 2026 (second update) — Stated the everyday amount against the trial range (a teaspoon of powder, about 2.5 grams, inside the 1.2 to 4.8 grams a day used in the longer trials) and attributed the plugged-duct amount to the breastfeeding guideline; added a choline-per-serving chart and a choline pathway diagram (acetylcholine, betaine and homocysteine, TMAO); shortened the ulcerative colitis summary; opened the gut-lining section with a direct answer and noted that the soy lecithin lab and mouse study didn't test sunflower lecithin; removed a repeated cholesterol caveat and its 1989 review reference; corrected the sunflower seed allergy detail to the 230 children it describes; labeled the 3.38% choline figure as EFSA's for a single batch; added trial size and dose to the blood-sugar summary; expanded the FAQ answers on side effects, milk supply, choline, soy allergy, cholesterol and food uses; and added FAQs on sunflower lecithin vs. phosphatidylcholine and when to take it.

Originally published April 25, 2024. —

References

  1. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Mortensen A, Aguilar F, Crebelli R, Di Domenico A, Frutos MJ, Galtier P, et al. Re-evaluation of lecithins (E 322) as a food additive. EFSA J. 2017;15(4):e04742. doi:10.2903/j.efsa.2017.4742. PMID:32625454
  2. Axe J, Cole W. Heal Your Cells. 2026 (the line quoted on phospholipids is in the Nearly Essential Fats section, under Phospholipids).
  3. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central: Sunflower lecithin pure powder (Branded Foods). FDC ID 2417875. Published December 22, 2022. Accessed September 30, 2026.
  4. Mitchell KB, Johnson HM, Rodríguez JM, Eglash A, Scherzinger C, Zakarija-Grkovic I, et al. Academy of Breastfeeding Medicine Clinical Protocol #36: The Mastitis Spectrum, Revised 2022. Breastfeed Med. 2022;17(5):360-376. doi:10.1089/bfm.2022.29207.kbm. PMID:35576513
  5. Hossain MM, Tovar J, Cloetens L, de Kam S, Nilsson A. Oat polar lipids and sunflower lecithin similarly improve cardiometabolic risk markers and appetite controlling hormone responses after breakfast and a subsequent lunch. A randomized crossover study in healthy adults. Front Nutr. 2024;11:1497844. doi:10.3389/fnut.2024.1497844. PMID:39568724
  6. Wang X, Li D, Li XY, Lu W, Ding H, Qi C, et al. Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice. Adv Sci (Weinh). 2025;12(30):e2405222. doi:10.1002/advs.202405222. PMID:40344642
  7. Stefan N, Hartleb M, Fan J, Demir M, Schattenberg JM, Gietka J, et al. Effect of Essential Phospholipids in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Phase 4 Clinical Trial. Liver Int. 2026;46(5):e70601. doi:10.1111/liv.70601. PMID:41889076
  8. Axe J. #1 Cellular Health EXPERT: Most Longevity Advice Gets It Backwards. The Dr. Josh Axe Show. 2026.
  9. Axe J. Cellular Health EXPERT: How to Build Bulletproof Cells for Energy, Detox & Longevity. The Dr. Josh Axe Show. 2025.
  10. Axe J. The Hidden Reason Your Body Can't Heal Itself! The Dr. Josh Axe Show. 2026.
  11. Axe J. This ONE Thing Controls Your Energy, Healing, and Health. The Dr. Josh Axe Show. 2025.
  12. International Service for the Acquisition of Agri-biotech Applications (ISAAA). GM Approval Database: GM crops list. Accessed September 30, 2026.
  13. U.S. Department of Agriculture, Economic Research Service. Adoption of Genetically Engineered Crops in the United States: Recent Trends in GE Adoption. Accessed September 30, 2026.
  14. Ibrahim MMS, Elkhedir A, Shakak MAS, Alagib AA. Characterization and application of lecithin powders from sunflower and peanut to enhance oil stability in peanut butter. Food Chem X. 2025;31:103176. doi:10.1016/j.fochx.2025.103176. PMID:41211153
  15. Drugs and Lactation Database (LactMed®). Lecithin. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Updated July 15, 2026. PMID:30000831
  16. Martín-Hernández C, Bénet S, Marvin-Guy LF. Characterization and quantification of proteins in lecithins. J Agric Food Chem. 2005;53(22):8607-13. doi:10.1021/jf0510687. PMID:16248560
  17. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central: Liquid sunflower lecithin (Branded Foods). FDC ID 2373459. Published December 7, 2022. Accessed September 30, 2026.
  18. Axe J. Seed Oils: Are They Bad? Best & Worst Oils Ranked. DrAxe.com. 2026.
  19. Zeisel SH. A brief history of choline. Ann Nutr Metab. 2012;61(3):254-8. doi:10.1159/000343120. PMID:23183298
  20. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67(11):615-23. doi:10.1111/j.1753-4887.2009.00246.x. PMID:19906248
  21. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press; 1998. doi:10.17226/6015
  22. Wallace TC, Fulgoni VL. Usual Choline Intakes Are Associated with Egg and Protein Food Consumption in the United States. Nutrients. 2017;9(8):839. doi:10.3390/nu9080839. PMID:28783055
  23. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central: Beef, variety meats and by-products, liver, raw (SR Legacy). FDC ID 169451. Published April 1, 2019. Accessed September 30, 2026.
  24. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central: Egg, whole, cooked, hard-boiled (SR Legacy). FDC ID 173424. Published April 1, 2019. Accessed September 30, 2026.
  25. Axe J, Rubin J. The Biblio Diet. 2025.
  26. Akosman S, Samayamanthula S, Leigh A, Li R, Bitar M, Wroblewski K. Effect of Sunflower Lecithin Supplementation on Meibomian Gland Function in Adults With Dry Eye Disease. Cureus. 2025;17(12):e98738. doi:10.7759/cureus.98738. PMID:41523453
  27. Hirose A, Terauchi M, Osaka Y, Akiyoshi M, Kato K, Miyasaka N. Effect of soy lecithin on fatigue and menopausal symptoms in middle-aged women: a randomized, double-blind, placebo-controlled study. Nutr J. 2018;17(1):4. doi:10.1186/s12937-018-0314-5. PMID:29310653
  28. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. doi:10.7326/0003-4819-147-9-200711060-00004. PMID:17975182
  29. Karner M, Kocjan A, Stein J, Schreiber S, von Boyen G, Uebel P, et al. First multicenter study of modified release phosphatidylcholine "LT-02" in ulcerative colitis: a randomized, placebo-controlled trial in mesalazine-refractory courses. Am J Gastroenterol. 2014;109(7):1041-51. doi:10.1038/ajg.2014.104. PMID:24796768
  30. Dignass A, Stremmel W, Horyński M, Poyda O, Armerding P, Fellermann K, et al. Modified-Release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-Blind, Randomized, Placebo-Controlled Trials. Clin Gastroenterol Hepatol. 2024;22(4):810-820.e7. doi:10.1016/j.cgh.2023.09.031. PMID:37806372
  31. Evans M, Njike VY, Hoxley M, Pearson M, Katz DL. Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause. 2007;14(1):141-9. doi:10.1097/01.gme.0000227404.83686.1b. PMID:17006376
  32. Oosthuizen W, Vorster HH, Vermaak WJ, Smuts CM, Jerling JC, Veldman FJ, et al. Lecithin has no effect on serum lipoprotein, plasma fibrinogen and macro molecular protein complex levels in hyperlipidaemic men in a double-blind controlled study. Eur J Clin Nutr. 1998;52(6):419-24. doi:10.1038/sj.ejcn.1600580. PMID:9683394
  33. Böckmann KA, Franz AR, Minarski M, Shunova A, Maiwald CA, Schwarz J, et al. Differential metabolism of choline supplements in adult volunteers. Eur J Nutr. 2022;61(1):219-230. doi:10.1007/s00394-021-02637-6. PMID:34287673
  34. Higgins JP, Flicker L. Lecithin for dementia and cognitive impairment. Cochrane Database Syst Rev. 2003;(3):CD001015. doi:10.1002/14651858.CD001015. PMID:12917896
  35. Axe J. Hidden Signs Your Liver Is Sluggish (And What To Do Before It Becomes Serious). The Dr. Josh Axe Show. 2026 (choline and phosphatidylcholine at 43:20-43:33).
  36. Chan MM, Nohara M, Chan BR, Curtis J, Chan GM. Lecithin decreases human milk fat loss during enteral pumping. J Pediatr Gastroenterol Nutr. 2003;36(5):613-5. doi:10.1097/00005176-200305000-00004. PMID:12717084
  37. Fischer LM, da Costa KA, Galanko J, Sha W, Stephenson B, Vick J, et al. Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. Am J Clin Nutr. 2010;92(2):336-46. doi:10.3945/ajcn.2010.29459. PMID:20534746
  38. Cheatham CL, Goldman BD, Fischer LM, da Costa KA, Reznick JS, Zeisel SH. Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2012;96(6):1465-72. doi:10.3945/ajcn.112.037184. PMID:23134891
  39. Cho CE, Aardema NDJ, Bunnell ML, Larson DP, Aguilar SS, Bergeson JR, et al. Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men. Nutrients. 2020;12(8):2220. doi:10.3390/nu12082220. PMID:32722424
  40. Wilcox J, Skye SM, Graham B, Zabell A, Li XS, Li L, et al. Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial. Am J Med. 2021;134(9):1160-1169.e3. doi:10.1016/j.amjmed.2021.03.016. PMID:33872583
  41. Mourad AM, de Carvalho Pincinato E, Mazzola PG, Sabha M, Moriel P. Influence of soy lecithin administration on hypercholesterolemia. Cholesterol. 2010;2010:824813. doi:10.1155/2010/824813. PMID:21490917
  42. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575-84. doi:10.1056/NEJMoa1109400. PMID:23614584
  43. Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, et al. Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics. Int J Toxicol. 2020;39(2_suppl):5S-25S. doi:10.1177/1091581820953123. PMID:32975152
  44. Shah A, Patel N, Dehbozorgi S, Cox AL, Baker MG. Sunflower Seed Allergy: Natural History, Oral Food Challenge Outcomes, and Review of the Literature. J Allergy Clin Immunol Pract. 2026;14(7):1644-1651. doi:10.1016/j.jaip.2026.03.032. PMID:41967675
  45. Paschke A, Zunker K, Wigotzki M, Steinhart H. Determination of the IgE-binding activity of soy lecithin and refined and non-refined soybean oils. J Chromatogr B Biomed Sci Appl. 2001;756(1-2):249-54. doi:10.1016/s0378-4347(01)00085-8. PMID:11419717
  46. Awazuhara H, Kawai H, Baba M, Matsui T, Komiyama A. Antigenicity of the proteins in soy lecithin and soy oil in soybean allergy. Clin Exp Allergy. 1998;28(12):1559-64. doi:10.1046/j.1365-2222.1998.00431.x. PMID:10024228
  47. Naimi S, Viennois E, Gewirtz AT, Chassaing B. Direct impact of commonly used dietary emulsifiers on human gut microbiota. Microbiome. 2021;9(1):66. doi:10.1186/s40168-020-00996-6. PMID:33752754
  48. Wellens J, Vanderstappen J, Hoekx S, Vissers E, Luppens M, Van Elst L, et al. Effect of Five Dietary Emulsifiers on Inflammation, Permeability, and the Gut Microbiome: A Placebo-controlled Randomized Trial. Clin Gastroenterol Hepatol. 2026;24(4):1092-1101. doi:10.1016/j.cgh.2025.08.005. PMID:40816342
  49. Yazici D, Hayashi Y, Pat Y, Hotie J, Balci MA, Ardicli S, et al. Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro-Inflammatory Responses and IgE Production. Allergy. 2026. doi:10.1111/all.70473. PMID:42568319
Dr. Josh Axe, DC, DNM, CNS
Doctor of Natural Medicine · Founder, DrAxe.com

Dr. Axe is a certified doctor of natural medicine, clinical nutritionist, and multiple New York Times bestselling author. He has spent 20+ years in clinical practice helping people heal at the root cause and founded one of the most-visited natural-health platforms in the world.

Read the full bio →

This article is for educational purposes. See our medical disclaimer.