Reishi Mushroom Benefits, Uses, Dosage and Side Effects - Dr. Axe

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Reishi Mushroom: Fight Disease, Boost Immunity & Improve Liver Detox



Reishi mushroom - Dr. Axe

The reishi mushroom is an edible type of medicinal fungus that has been used for its healing abilities for thousands of years and fits the definition of a true superfood. Also known as Ling Zhi in Chinese, these mushrooms are anti-inflammatory and tied to longevity, better immune function and mental clarity, earning them the nickname “king of mushrooms.”

Throughout history in holistic medicine, reishi mushrooms have been considered adaptogenic herbs. This means they help your body deal with the negative effects of stress, such as increased inflammation, depleted energy levels, damaged blood vessels and various types of hormonal imbalances.

Studies have repeatedly shown that reishi mushrooms have antioxidant abilities that allow them to strengthen the body’s defenses against cancer, autoimmune conditions, heart disease, allergies, infections and more.

Believe it or not, this all just skims the surface of the health benefits that reishi mushrooms have to offer.

Ready to learn more? Let’s take a look at why you should consider adding this incredible medicinal mushroom into your routine and what reishi mushrooms health benefits can do for you.

What Are Reishi Mushrooms?

What is reishi? What is ganoderma?

Like other disease-fighting mushrooms, reishi mushrooms are a type of fungus that grow outdoors.

They’re native to several parts of Asia, including China, Korea and Japan. While they’re edible and often described as bitter-tasting with a tough texture, you’re much more likely to find them in supplement, tincture or powder form.

Reishi mushrooms, also known by their scientific name Ganoderma lucidum, grow above ground and produce “a fruiting body” along with connective strands (called mycelium), which are turned into an herbal medicines, tinctures, teas, powders and extracts.

Also known as lingzhi mushroom, you may be surprised to learn just how long lingzhi mushroom benefits have been utilized.

For most of history in Traditional Chinese Medicine, fully grown reishi mushrooms were dried, cut into slices, boiled in hot water and then steeped to make a healing tea/soup. Today, manufacturers of reishi products use a processing technique in which reishi is boiled multiple times at a high pressure, allowing the active ingredients to be extracted to form a tincture.

Thanks to the concentrated compounds that these mushrooms contain, potential reishi mushroom benefits include protection against tumor formation, improved liver function, better heart health, enhanced blood sugar control, and a reduced risk of asthma, allergies and infection.

How the Reishi Mushroom Works

Over the past several decades, dozens of different studies conducted in Japan, China, the U.S. and the U.K. have demonstrated that reishi mushrooms are capable of offering protection against numerous diseases or illnesses, including:

  • inflammation
  • fatigue (including chronic fatigue syndrome)
  • frequent infections (urinary tract, bronchitis, respiratory infections, etc.)
  • liver disease
  • food allergies and asthma
  • digestive problems, stomach ulcers and leaky gut syndrome
  • tumor growth and cancer
  • skin disorders
  • autoimmune disorders
  • diabetes
  • viruses, including the flu, HIV/AIDS or hepatitis
  • heart disease, hypertension, high blood pressure and high cholesterol
  • sleep disorders and insomnia
  • anxiety and depression

Because they work as an “immune modulator,” reishi mushrooms can help restore hormonal balance, bring the body back to homeostasis and regulate activity of the immune system. This can help fight tumors and cancerous cells.

Research shows that reishi mushrooms act as a normalizing substance, regulating various cellular functions and systems, including the endocrine (hormonal), immune, cardiovascular, central nervous and digestive systems.

One of the biggest reishi benefits is that it’s capable of doing so much, yet produces hardly any side effects. Reishi mushrooms are much less toxic than traditional medications as well.

In fact, most people report a quick improvements in their energy levels, mental focus and mood while also experiencing a reduction in aches, pains, allergies, digestive issues and infections.

The secret behind their healing potential? The various active ingredients that the reishi mushroom contains account for this.

These ingredients include complex sugars known as beta-glucans, plant sterols that act as precursors to hormones in the body, polysaccharides that fight cancer cell development and acidic substances called triterpenes that turn off the body’s response to allergies.

Recent findings suggest that reishi mushrooms can lower inflammation and increase the release of natural killer cells, which work to remove various types of mutated cells from the body. This makes the reishi mushroom ideal for preventing heart disease and working as a natural cancer treatment.

Some of the ways that reishi mushrooms work to promote better health include:

  • activating cytotoxic receptors (NKG2D/NCR)
  • inhibiting cell proliferation
  • suppressing vascular endothelial growth factor
  • increasing plasma antioxidant capacity
  • enhancing immune response
  • converting excess testosterone to dihydrotestosterone

Health Benefits

1. Contains Powerful Anti-Cancer Properties

Just like other anti-inflammatory foods, reishi mushrooms are packed with important nutrients, including antioxidants, beta-glucans and amino acids. Researchers believe that some of the most beneficial components of the reishi mushroom are its polysaccharides.

These are water-soluble types of nutrient found in carbohydrate foods that are known to have anti-tumor abilities.

Polysaccharides, which also found in other beneficial plant foods like sweet potatoes or beets, are immune-modulating substances. They are compounds that help reishi mushrooms protect the DNA and block cell mutations while preserving healthy cells in the body.

According to some studies, certain medicinal mushrooms help fight cancer because polysaccharides have important biological benefits, including antioxidant, neuro-protective, radio-protective, anti-diabetes, anti-osteoporosis and anti-fatigue abilities.

Additionally, laboratory tests demonstrate that the triterpenes found in reishi mushrooms may also have cancer-fighting properties. This is one reason why brightly colored or bitter-tasting, antioxidant-rich foods like pumpkin, berries and black rice have a reputation for promoting health.

Triterpene compounds seem to inhibit tumor formation and metastases by limiting the attachment of cancerous cells to endothelial cells. Beta-glucans can also help fight off cancer formation by blocking the growth and spread of cancer cells and increasing the activity of the immune system.

Studies have turned up promising results on the link between the reishi mushroom and cancer prevention. It has been successfully used to help fight cancer of the breasts, ovaries, prostate, liver and lungs in in-vitro studies, sometimes in combination with other treatments.

Research in cancer patients suggests that reishi has antiproliferative and chemopreventive effects. It helps alleviate side effects of chemotherapy, like low immunity and nausea, and potentially enhances the efficacy of radiotherapy.

All this makes the reishi mushroom one of the most powerful cancer-fighting foods available and shows reishi mushroom powder benefits include supporting immunity to combat chronic disease.

2. Improves Liver Function

The liver is one of the most vital organs in the body. It is responsible for aiding in detoxification and helping clean, process, store and circulate healthy blood and nutrients.

Reishi mushrooms work as adaptogens to help improve liver function and prevent liver disease. They allow your body to flush out toxins and bacteria more efficiently and improve immunity against diseases that can develop over time.

A 2013 study published in the International Journal of Medicinal Mushrooms found that reishi induces hepatoprotective effects on acute liver injury because it contains antioxidant properties and fights harmful immune responses that slow down liver function — adding to list of benefits of reishi mushrooms.

3. Promotes Heart Health

The triterpenes found in the reishi mushroom may have blood pressure-lowering abilities as well as benefits for blood-clotting and cholesterol. This is likely because they help lower inflammation within blood vessels and arteries while also restoring hormonal balance.

High blood pressure and high cholesterol can sometimes be caused by hormonal issues, including thyroid disorders or high amounts of stress. Reishi mushrooms help restore optimal hormonal levels to strengthen the cardiovascular system.

In addition to lowering blood pressure, reishi mushroom extract can improve overall circulation, lower inflammation that worsens heart problems and prevent clogged arteries by keeping cholesterol under control — yet another one of the impressive reishi health benefits.

All about the reishi mushroom - Dr. Axe

4. Balances Hormone Levels

Reishi mushrooms work as adaptogens. They can help your body cope with stress more efficiently and help regulate hormone levels to optimize your health.

Although research is currently limited to mostly animal models, some studies indicate that reishi mushroom extract could help normalize levels of certain receptor hormones, which may be beneficial in the treatment of cancer.

Other studies show that it can protect and positively impact the endocrine system, which encompasses the glands throughout the body that are responsible for the production of hormones. This could have far-reaching effects on many aspects of health, as the endocrine system has a direct impact on metabolism, growth, sleep, mood and sexual function.

5. Stabilizes Blood Sugar

Sustaining high levels of blood sugar can bring detrimental effects to overall health, causing symptoms like fatigue, unintentional weight loss and frequent urination. Some research shows that reishi mushrooms may have anti-diabetic properties, helping to maintain normal blood sugar levels to prevent adverse side effects.

For example, one review out of Taiwan showed that reishi mushrooms were able to decrease levels of both blood sugar and insulin in mice. They also helped modify levels of certain enzymes involved in blood sugar control and improved the way that the body uses insulin to transport sugar from the bloodstream to the tissues to be used as fuel.

6. Fights Allergies and Asthma

Triterpenes are active ingredients in reishi mushrooms. They are a type of ganoderic acid tied to a reduction in allergies and histamine reactions associated with asthma.

For this reason, the reishi mushroom is often used as a safe and effective asthma natural remedy. Triterpenes are capable of lowering allergic reactions because of the way they affect the immune system, strengthen the digestive organs, protect the gut lining, lower inflammation, inhibit a histamine release, improve oxygen utilization and improve liver functions.

7. Protects Against Infections and Viruses

Reishi mushrooms are considered natural antiviral, antibacterial and antifungal substances thanks to the active compounds that they contain. For example, aside from relieving allergies, triterpenes offer protection against microbial, viral and fungal infections.

Triterpenes can be found in many plant foods that taste somewhat bitter, a sign that they’re protective in nature and defend the plant against predators.

Because reishi mushrooms can improve blood circulation and lower inflammation, they can help resolve infections more quickly, reduce pain and fight fatigue. Reishi mushrooms have been used to help treat symptoms and underlying causes of urinary tract infections, hepatitis and even HIV/AIDS, among other reishi mushrooms benefits.


In supplement form, reishi mushrooms typically contain little to no calories and only a small amount of dietary fiber and protein. However, the true reishi mushroom health benefits come from the ingredients that aren’t listed on the nutrition label.

In particular, reishi mushrooms are jam-packed with antioxidants and health-promoting compounds, such as polysaccharides and triterpenes. These powerful compounds are linked to a number of health benefits and have been shown to account for many of the anti-inflammatory, anti-cancer and anti-diabetic properties of the reishi mushroom.

Many forms of holistic medicine take advantage of the full scope of health benefits of reishi mushroom and use it to treat a variety of ailments.

Reishi mushrooms are an especially common ingredient in Traditional Chinese Medicine and have been used as a staple for thousands of years. They are believed to nourish the heart, preserve liver health, slow aging, and enhance vitality, stamina and strength.

They’re also said to promote calmness and relaxation and often used to supplement spiritual practices.


Are mushrooms good for you? If you’ve ever had any doubts, take a look at any of the powerful nutrients found in of any of these medicinal mushrooms and you’re bound to be a believer in the many health benefits of mushrooms, whether we’re talking mushroom reishi, turkey tail or more.

Here’s a quick breakdown of how the reishi mushroom compares to other popular varieties of medicinal mushrooms:

  • Reishi Mushroom: balances hormone levels, improves heart and liver function, stabilizes blood sugar levels, and fights allergies, asthma and infection
  • Turkey Tail Mushroom: feeds the beneficial bacteria in your gut, prevents infections and combats cancer cells
  • Lion’s Mane Mushroom: protects brain function, relieves inflammation, preserves digestive health and fights free radical formation
  • Chaga Mushroom: enhances endurance, reduces inflammation, stimulates immune function and contains antiviral properties
  • Shiitake Mushroom: supports immunity, fights cancer cells, promotes skin health and supplies a hearty dose of important B vitamins to maintain energy levels

Additionally, different mushroom varieties have distinct differences in the ways that they are used and enjoyed. For example, reishi, turkey tail and chaga are all most often found in supplement form, while lion’s mane and shiitake are more palatable and can be swapped in for other mushrooms in your favorite recipes.

How to Use

Wondering where to buy reishi mushroom supplements? Thanks to their growing popularity, you’re likely to come across reishi mushroom powder, capsule or extract supplements in health food stores or online.

It’s important to always read the directions carefully since the proper reishi mushroom dose can vary depending on how concentrated the product is. The likelihood of having side effects can increase when you take too much.

If you feel a little more adventurous, you can also try your hand at mushroom foraging. You can typically find reishi mushrooms growing in warm regions throughout Asia, the Southeastern United States, Southern Europe and the South Pacific.

If you have a green thumb, you can also grow the red reishi mushroom at home by purchasing reishi spawn online.

When purchasing reishi, ideally look for products that are certified pure, produced in Asian countries, and in extract or essence form. There are many different types of reishi products available, all of which have different levels of active ingredients that are affected by factors including the plant’s mother fungi, the growing conditions and the processing method used to extract the reishi.

Products from Japan are considered to be some of the purest and are usually cultivated using techniques that preserve the delicate compounds in reishi. Check the product’s labeling for the species name (Ganoderma lucidum), extract ratio, country of origin and if any fillers are added.

Reishi mushrooms are often said to be most effective if you take them in the morning on an empty stomach. Drinking water along with reishi seems to help them absorb best, as does pairing them with vitamin C foods, which can ensure proper absorption of the active ingredients and antioxidants.

You can also try using them to brew a cup of reishi mushroom tea or Ganoderma coffee to start your morning on the right foot.


There are limitless ways to add reishi into your diet and reap the multitude of rewards that it has to offer. Here are a few simple and delicious recipes to get you started, including reishi tea:

Supplements and Dosage

The recommended reishi mushroom dosage can vary based on the type of supplement that you choose to use. When eaten fresh, the dosage can range between 25–100 grams daily.

Conversely, reishi mushroom capsules, powders and extract forms contain more concentrated doses. Ganoderma extract and other supplements require smaller amounts to achieve the same results.

Most studies have found that two to nine grams of mushroom extract in the form of reishi mushroom powder, capsules or tinctures is enough to positively impact health. However, supplements can contain varying amounts of reishi extract, so it’s best to follow the instructions on your specific dosage listed on your supplement to make sure you get the right amount.

For example, you can take a one-gram reishi tablet once or twice a day, and alway make sure your reishi mushroom tablet is made from organic reishi and contains to unnatural, unhealthy ingredients.


The use of the reishi mushroom was first recorded over 2,000 years ago. It was frequently referred to as the “Mushroom of Immortality” in ancient texts. Around 200–250 C.E., the “Divine Farmer’s Classic of Pharmaceutics” categorized different varieties of mushrooms based on which part of the body they benefited.

According to the text:

Chi Zhi (Ganoderma rubra) is bitter and balanced. It mainly treats binding in the chest, boosts the heart qi, supplements the center, sharpens the wits, and [causes people] not to forget [i.e., improves the memory]. Protracted taking may make the body light, prevent senility, and prolong life so as to make one an immortal. Its other name is Dan Zhi (Cinnabar Ganoderma). It grows in mountains and valleys.

Today, the reishi mushroom is recognized around the world for its powerful health benefits and medicinal properties. As more and more research is released confirming the potent effect that it can have on overall health, it has joined the ranks of other medicinal mushrooms like the chaga mushroom and the portobello mushroom, cementing its status as a true powerhouse of nutrition.

Risks and Side Effects

Reishi mushrooms have been used for thousands of years in all kinds of patients, and very few side effects have ever been recorded. Reishi is classified as “Class 1: Herbs that can be safely consumed when used appropriately.”

On occasion, some mild digestive upset and skin rashes may occur, but these side effects seem to go away and are typically only a threat in sensitive people with impaired immune systems.

While reishi mushrooms are safe, effective and well-tolerated by most people, there are some instances when you want to talk to your doctor before using them on your own. According to studies, the reishi mushroom appears to be safe for adults when taken by mouth in appropriate doses for up to one year.

It’s possible for powdered forms of reishi to be stronger or contaminated in some rare cases, which can increase the risk for toxicity, so use caution and purchase reishi powder from a reputable company to get the best reishi powder benefits.

If you notice any of the following reishi mushroom side effects, discontinue use immediately and visit your doctor to make sure you’re not having an allergic reaction or experiencing liver toxicity:

  • dryness of the mouth
  • dry or itchy throat
  • itchiness in the nasal area
  • strong indigestion, heartburn or stomach upset
  • nosebleeds
  • bloody stool
  • skin rashes

If you’re pregnant or breastfeeding, it’s best to avoid reishi mushrooms unless under medical supervision. There hasn’t been much research done on the safety and long-term effects for these populations.

Additionally, if you have had any type of bleeding disorder; recently underwent surgery; take blood pressure medications, blood thinners, chemotherapy drugs or immunosuppressant medications; or have trouble with blood clotting, don’t take reishi mushrooms since they can increase blood pressure, impact blood clotting and increase the risk for bleeding.

Final Thoughts

  • The reishi mushroom is a powerful medicinal mushroom that comes with a long list of potential health benefits.
  • A few of the top perks that make the reishi mushroom benefits list include improved liver and heart health; protection against allergies, asthma and infections; and cancer prevention. Ganoderma lucidum benefits can also include helping balance hormone levels and keeping blood sugar in check.
  • Although reishi mushrooms are edible, they are mostly found as supplements in the form of capsules, powders, extracts and tinctures.
  • Reishi mushrooms are generally considered safe but can come with some side effects and may interfere with certain medications. Be mindful of reishi dosage recommendations on your supplement.
  • Add these medicinal mushrooms to soups, teas, coffees and broths for a quick and convenient way to boost the nutritional content of your favorite meals and beverages.

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