Can Supplements Help Reverse Huntington’s Disease?

Huntington's disease - Dr. Axe

You’ve most likely heard of disorders like ALS, Parkinson’s disease and Alzheimer’s disease, but you may not have heard about an equally terrifying condition called Huntington’s disease (HD).

Capable of damaging nerves and disturbing important chemical-signaling processes that take place between the brain and other body parts, some people even describe common Huntington’s disease symptoms as “like having ALS, Parkinson’s and Alzheimer’s simultaneously.”

Clearly, this is a condition that can drastically affect someone from going about even normal, everyday activities. Unfortunately, there is no known cure — however, research suggests supplementation may help reverse HD to a certain extent.

So what are the signs and symptoms of Huntington’s disease, and what treatment options are out there to help curb and potentially reverse this debilitating condition? Let’s explore.


What Is Huntington’s Disease?

Huntington’s disease is an unfortunate and somewhat rare genetic brain disorder that currently affects about 30,000 Americans. According to the Huntington’s Disease Society of America, HD is called a “family disease” because children who have a parent with HD have about a 50/50 chance of carrying the faulty gene themselves. (1)

Sadly, people with HD usually experience drastic personality changes, loss of memory and impaired motor skills over the course of 10–25 years, which makes it hard to live a normal, functioning life.

HD is a debilitating disease that disturbs someone’s ability to think, reason, connect socially, remember information and move. While emerging research suggests that certain natural supplements might be able to help stall the progression of HD, currently it’s classified as a progressive fatal disorder that has no known proven cure.

Despite the option to perform testing to find out if someone has inherited the HD gene, according to survey results published by Harvard University and the MassGeneral Institute for Neurodegenerative Disease,

more than 90 percent of those in the United States who know they are at risk for HD because of their family history have abstained from genetic testing, often because they fear discrimination or don’t want to face the stress and anxiety of knowing they are destined to develop such a devastating disease. (2)


5 Natural Treatments for Huntington’s Disease

Traditionally, most physicians prescribe a number of medications to help control the various emotional and physical symptoms of HD, although these are used to make living easier and don’t actually address the underlying problem at its root. As of 2008, some progress was made when the U.S. Food and Drug Administration approved the drug tetrabenazine to treat involuntary writhing movements of HD, making it the very first HD drug approved for use in the U.S.

One of the downsides to taking medication for HD and other cognitive disorders is that they commonly have a lot of side effects, such as fatigue, insomnia, appetite and mood changes, etc. (3)

Research shows the most effective treatment plan for Huntington’s disease is holistic — one that treats the “whole person” with cognitive skill building, supplements, an anti-inflammatory diet and appropriate physical activity.

What else besides medications might be able to help stall the progression of Huntington’s disease? Here are several ways that practitioners are now managing HD symptoms:

1. Reduce Inflammation

Whether it’s a disorder of the cardiovascular, endocrine, immune or central nervous system, inflammation only makes matters worse. Scientific investigations find that high inflammation levels and oxidative stress caused by free radicals can speed up disease progression and worsen symptoms.

Using electronic and other technologies, researchers are now beginning to better understand how inflammation is related to mutated cells, defective energy metabolism (a defect in the mitochondria) and oxidative stress (normal metabolic activity in the brain that produces toxic compounds called free radicals), which all contribute to disease formation.

Inflammation, worsened by factors like a poor diet, environmental pollution, toxin exposure, high stress levels and inactivity, can affect immunity and the body’s “tropic factors,” meaning the natural chemical substances that are supposed to protect against cell changes and death.

To lower inflammation, it’s important to eat a healing diet that’s nutrient-dense, limit use of harsh chemicals in household/beauty products, avoid smoking, stay active and try to manage stress.

2. Maintain Physical Activity

It’s been found that people with HD can greatly benefit from staying active as long as they can. Doctors consider it “extremely important for people with HD to maintain physical fitness as much as possible” since those who exercise and keep active tend to maintain better control over physical movements for longer.

While exercise or even everyday activity can become harder as time goes on, regular movement and exercise can make a big impact. With neurodegenerative diseases, it’s also now accepted that regular and sustained physical activity has the potential to benefit cardiovascular health and other factors that can impair quality of life and lead to complications, adding this to the list of the benefits of exercise.

Studies have shown that in HD patients, physical activity can help manage stress from social stigma, lack of motivation and trouble with executive functions. (4)

3. Adjust Diet to Stall Weight Loss

Throughout the progression of Huntington’s disease, weight loss usually occurs, sometimes very quickly and to the point that it causes serious complications. While it becomes harder and harder to chew normally and safely, changing someone’s diet to make sure he or she consumes enough nutrients and calories is important. (5)

This helps fight complications of being underweight like worsened depression, very low energy, thyroid gland changes and poor digestion. Helping people with HD maintain their appetites as long as possible can be very helpful. It’s also useful to make food easier to consume, such as pureeing or blending foods into smoothies, soups, etc.

In addition, intermittent fasting has been shown to have positive effects on neurological disorders, so it may not hurt to practice fasting as well.

4. Cognitive Training

Setting up a clear schedule, following a routine and practicing reminders of daily life seem to be helpful when it comes to managing cognitive and psychiatric disorders. Doctors recommend that family and caregivers of those with HD help create an environment that limits stress, too much difficult decision-making and the need to learn new information often. This can mean:

  • Using calendars and clear schedules
  • Creating a predictable routine
  • Setting reminders
  • Keeping the living area organized
  • Prioritizing certain activities over others
  • Staying social and practicing hobbies to lower stress
  • Breaking down difficult tasks into manageable steps
  • Creating a calm living environment that is structured and has limited uncertainty
  • Avoiding family conflict, fights and other stressors

5. Natural Supplementation

Early studies done by Massachusetts General Hospital find that high doses of certain supplements, namely the nutritional compound called creatine can help delay the onset of symptoms of Huntington’s disease. Creatine was safe and well-tolerated by most of the 64 study participants who were either confirmed to be carrying the HD gene or at a high risk but not yet tested. Using neuroimaging studies, the researchers found that treatment slowed regional brain atrophy and progression of presymptomatic HD. (6)

HD damages brain cells by interfering with cellular energy production, leading to a depletion of adenosine triphosphate (ATP). ATP is the underlying molecule that powers most biological processes and essentially gives our cells”energy.” Creatine has long been known to help restore ATP and maintain cellular energy, which is why it’s being studied in the treatment of Parkinson’s disease, ALS and spinal cord injuries, which are all impacted by neurodegeneration. In earlier studies, daily doses of 10 grams or less of creatine have been used without much success, but newer studies are evaluating doses as high as 40 grams daily and finding more promise.

In the past, privacy and patient autonomy have been an obstacle in testing genetic disorders. The 2014 study design was one of the first of its kind to test genetic diseases without needing subjects to first be screened for whether or not they carried the gene, since some preferred not to know.

Professors of neurology at Harvard Medical School are currently continuing to study the effects of creatine in HD patients by leading a worldwide phase 3 trial (CREST-E) of high-dose creatine in early symptomatic HD. At this time, high doses of creatine should be used only under the care of a doctor, although in the future we might see this option become more widely accessible.

 

Huntington's disease alternative treatments - Dr. Axe

 


On the Horizon: More Hope for Treating Huntington’s Disease

Aside from creatine, numerous other supplements and complimentary forms of medicine are being studied in regard to their ability to stall, prevent or reverse brain and nerve damage. Some include: antioxidants such as resveratrol, coenzyme Q10, vitamin E, ethyl-EPA, idebenone and various holistic health techniques. (7) Results from various studies using supplements/herbs have been mixed so far, with some patients experiencing improvements and others not reaching statistical significance that suggests they’re getting better.

What we can expect to see in the future is likely the emergence of holistic treatment plans that do more than mask symptoms with drugs. There’s a growing trend toward treating the “whole person” when it comes to disease management, regardless of the type of disease. (8) For example, various alternative therapies are now commonly used to reverse cognitive disorders, including:

  • avoiding chronic stress 
  • focusing on individualizing treatments and treating the whole person
  • promoting relaxation, self-care and self-healing
  • focusing on good nutrition and a nutrient-dense diet that is anti-inflammatory
  • using preventive practices like exercise, sleep and avoiding toxin exposure

While we need to wait to see what research emerges in years to come, it makes sense that even for genetic disorders, helping people stay in the best of health overall — including physically, mentally, spiritually and emotionally — will likely give them the best chance of  healing.


Symptoms of Huntington’s Disease

Like certain other cognitive or nerve disorders, Huntington’s disease symptoms aren’t usually present from a young age. Most people start developing HD symptoms between the ages of 30 and 50. Once they begin, symptoms tend to worsen over the next one to two decades until the disorder reaches a fatal point.

HD patients become very weak and as their immune systems suffer, which results in many people eventually developing illnesses like pneumonia or heart complications. While normally a healthy person can overcome these obstacles, someone with Huntington’s disease isn’t capable of recovering.

Common symptoms of Huntington’s disease include: (9)

  • Personality changes and mood disturbances
  • Symptoms of depression
  • Mood swings
  • Memory loss, forgetfulness
  • Impaired judgment and reasoning
  • Slurred speech
  • Involuntary movements (known as chorea)
  • Difficulty swallowing and eating
  • Loss of appetite, significant weight loss

How Huntington’s Disease Develops and Progresses

HD manifests by affecting nerves spread throughout just about the entire brain, including the striatum, subthalamic nucleus and substancia nigra. Certain areas of the brain are more vulnerable to the effects of nerve damage than others. The area called the basal ganglia is where a group of nerves cells are clustered together, which are called nuclei. HD damages parts of the nuelei, which are responsible for regulating body movements and also behaviors.

The “control center” of the brain is another area that’s damaged by HD, which is why someone’s judgment, rationalization and moods are also negatively impacted. Degeneration in this areas is what leads people over time to feel like they’re “losing their minds” with age.

HD is said to progress in  three stages: early HD, middle and late stage. (10)

Early Stage Huntington’s Disease

At first, someone experiences only subtle, sometimes unnoticeable symptoms like losing their balance, lacking coordination, or having some trouble swallowing and controlling the tongue. Others can start to see signs of involuntary movements (chorea) while in the early stages of HD.

As time goes on, difficulty reasoning and mood changes continue to develop. Someone might become depressed, irritable or prone to mood fluctuations — which can partially be due to the changes happening in the brain, but also worsened once a Huntington’s disease diagnoses is made. At this point, some doctors prescribe mood-controlling medications to help alleviate symptoms of depression, but as HD worsens, it becomes more and more difficult to work, maintain relationships and live alone.

Middle Stage Huntington’s Disease

Middle stage HD results in a further loss of physical control over movements, as nerves continue to become damaged. Ordinary activities and leading a normal life become harder to do at this point. Involuntary movements, shakes and slurred speech are common, which people often associate with being characteristic of other disorders like MS or Parkinson’s disease.

Medications can sometimes help the lack of movement control (chorea), while occupational and physical therapists might also enter the equation to further assist with coordination, stability, swallowing and walking.

Late Stage Huntington’s Disease

By the time someone has had HD for a number of years, he or she is usually totally dependent on others and might live in a full-time facility. Motor control becomes worsened in most cases, while someone also struggles to speak, chew, eat and walk. The parts of the brain responsible for memory, language and comprehending information also continue to decline, which means it’s hard to put sentences together or remember other people.

Because it’s hard to control the tongue and swallow normally, choking is also a major concern at this point, which means HD patients cannot eat alone. Once HD becomes fatal, it’s not the actual disorder that causes a person to die, but rather the illnesses they acquire in the process of its progression (like infections or heart problems) or complications of the disease (like choking, falling and rapid weight loss).

 

Three stages of Huntington's disease

 


Causes of Huntington’s Disease and How It’s Passed On

Surprisingly, we all carry a certain gene that ‘s linked to Huntington’s disease — however, people who wind up developing the disorder must inherit another specific genetic factor that expands and worsens the disorder. The “expanded” HD gene is passed from parent to child, and every person who inherits the gene eventually develops the disease. Whether one child in a family inherits the gene or not has no effect on whether other children in the family will or will not. (11)

While roughly 30,000 Americans have a diagnoses of HD, another 200,000 are at risk for developing the disorder genetically but have not yet started to display symptoms. Both men and women are equally susceptible to developing HD, and it affects people of all nationalities, ethnic groups and religions throughout the world.

Huntington’s disease is genetic (offspring inheriting an affected gene have a 50 percent chance of the disorder progressing), inherited and considered “autosomal dominant.” This means that the likelihood of the expanded HD gene passing from parent to child does not depend on the child’s gender; both females and males have an equal chance of being affected.

One of the saddest things about Huntington’s disease is that it often devastates entire families, since it can affect family members for many generations and make it hard to sustain relationships or a positive outlook. Children of patients with HD usually face a very high level of stress due to both the uncertainty of having the disorder potentially develop in years to come, plus the responsibility of taking care of a sick parent.

One of the hardest decisions a family usually faces is whether or not to perform prenatal or genetic testing in order to know if an unborn baby or child is affected by carrying the HD gene. Because there currently isn’t a proven cure or prevention method, there isn’t necessarily anything positive or preventative people can do once they find out they carry the gene or have passed it on to their offspring. However, some people choose to do testing as early as possible in order to know what’s ahead or to have more choices about how to handle the future.

In about 10 percent of cases, HD symptoms emerge in children or teens, since the vast majority don’t show symptoms until years later during middle age. This is called juvenile Huntington’s disease (JHD). Symptoms of JHD are somewhat different than adult onset HD and tend to get worse faster than adult HD. Common symptoms that appear in children can include trouble walking, instability, clumsiness or changes in speech.

Before the age of 18, genetic testing for HD is prohibited because authorities fear that children will not understand the full implications of HD or benefit from knowing what’s in their futures. If children begin showing signs of HD at a very young age before they turn 18, tests can be performed to confirm a partial diagnoses. If a woman is pregnant and wants to find out if the baby carries the gene, she can receive testing for the fetus early on between weeks 10–18 of her pregnancy.


Takeaways on Huntington’s Disease

While dealing with Huntington’s disease can feel hopeless at times, there are preventative measures and natural treatments to slow and even perhaps reverse this dreadful disease. There may not be a cure, but maintaining a healthy, organic diet is a key to reducing inflammation and staving off cognitive disorders like HD.

In addition, cognitive training along with physical activity promote brain health, which can strengthen the defense against rapid cognitive decline. And of course, there is promising research on the use of supplements to curb and potentially reverse this debilitating disorder.

Read Next: All About Resveratrol


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