Stevia Benefits, Types and Potential Side Effects - Dr. Axe

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7 Benefits of Stevia and How to Use the Different Types


Stevia - Dr. Axe

The stevia plant has been used for more than 1,500 years by people living in South America, including the Guaraní people of Brazil and Paraguay, who refer to it as ka’a he’ê, meaning “sweet herb.”

These native South Americans love using this non-caloric sugar substitute in their yerba mate tea, as medicine and as a sweet treat. In these countries, it also has been used specifically as a traditional medicine for burns, stomach problems, colic and even as a form of contraception.

It can help you cut down on your sugar consumption, but are there are stevia side effects that may make it bad for you?

Several articles and other sources online claim that there may be some negative stevia side effects. This can be confusing, especially because it’s often touted as one of the healthiest natural sweeteners around.

So is stevia bad for you? Fortunately, side effects are not typically common, especially if you choose the right product.

In this article, we’ll lay out for you both the good and the bad about how stevia side effects may affect your health, as well as the distinctions between the many types of this natural sweetener.

What Is Stevia?

Stevia is an herbal plant that belongs to the Asteraceae family, which means it’s closely related to ragweed, chrysanthemums and marigolds. Although there are over 200 species, Stevia rebaudiana Bertoni is the most prized variety and the cultivar used for production of most edible products.

Stevia can naturally add sweetness to recipes even without contributing calories. Stevia leaf extract is about 200 times sweeter than sugar, depending on the specific compound discussed, which means that you only need a tiny bit at a time to sweeten your morning tea or next batch of healthy baked goods.

In 1931, chemists M. Bridel and R. Lavielle isolated the two steviol glycosides that make the leaves of the plant sweet: stevioside and rebaudioside (with five variations: A, C, D, E and F). Stevioside is sweet but also has a bitter aftertaste that many complain about when using it, while isolated rebaudioside is sweet without the bitterness.

Many raw/crude stevia or minimally processed stevia products contain both types of compounds, whereas more highly processed forms only contain the rebaudiosides, which is the sweetest part of the leaf.

Rebiana, or high-purity rebaudioside A, is “generally recognized as safe” (GRAS) by the U.S. Food and Drug Administration (FDA) and may be used as an artificial sweetener in foods and beverages.

Research shows that using the whole leaf or purified rebaudioside A boasts some great health perks, but the same may not hold true for altered blends that actually contain very little of the plant itself.


When it comes to the options available today, it’s important to know that not all stevia sweeteners are created equal. In fact, there has been concern in recent years about counterfeit stevia or products laced with unwanted ingredients, which is one likely reason the FDA has been slow to approve all stevia leaf extracts and other products as GRAS.

Here is how some of these forms compare:

  • Crude stevia/green leaf stevia is the least processed of the types. The leaves are dried and ground into powder form, producing a final product that is only about 10–15 times sweeter than sugar. This unprocessed version more than likely contains a combination of steviosides and rebaudiosides.
  • Purified stevia extracts are also available. In the U.S., this type of sweetener is composed of rebaudioside A in either a pure extract or our third type (altered blends). Per FDA standards set forth in 2008, these extracts must contain over 95% or more pure rebaudioside A glycosides and may not contain other forms of rebaudiosides or steviosides in order to be legally marketed as food. While purified stevia extracts are more processed than green leaf varieties, their health perks seem to be on par with the unprocessed counterpart.
  • Finally, the least healthy option is altered stevia blends. By the time a product like this is placed on a shelf, very little of the stevia plant still remains, and many purified stevia extracts and altered blends are reported to be 200–400 times sweeter than sucrose. Some companies use processes to create these blends that include chemical solvents, including acetonitrile, which is toxic to the central nervous system, and a corn-based derivative called erythritol. The small amount remaining contains rebaudioside A only in the U.S.

Organic vs. Non-Organic

Organic Stevia

  • Made from organically grown stevia
  • Non-GMO
  • No glycemic impact
  • Naturally gluten-free

Unfortunately, even some organic versions contain fillers. Some aren’t truly pure stevia, so you should always read labels if you’re looking for a 100 percent stevia product.

Non-Organic Stevia

  • Does not have to be made from organically grown stevia, meaning it may be produced with pesticides or other chemicals
  • Non-GMO (there are currently no genetically modified cultivars of stevia in the world)
  • No glycemic impact
  • Naturally gluten-free

With non-organic brands, it’s very important to look for additional ingredients, like erythritol or inulin. Although stevia itself is always non-GMO, many non-organic products are combined with erythritol or other non-nutritive sweeteners, many of which are made from GMO ingredients like corn.

Related: What Is Functional Soda (& Is It Good for You)?


Is stevia really healthy? According to a 2020 review, “In addition to its hypoglycemic property, the stevia plant also exhibits antibacterial, anti-inflammatory, hypotensive, antiseptic, diuretic, anti-fertility and cardiotonic properties.”

Below are some of the main advantages associated with stevia use:

1. May Have Anticancer Abilities

In 2012, Nutrition and Cancer highlighted a groundbreaking laboratory study that, for the first time ever, showed that stevia extract could help kill off breast cancer cells. It was observed that stevioside enhances cancer apoptosis (cell death) and decreases certain stress pathways in the body that contribute to cancer growth.

Another in vitro study out of China also found that steviol, which is a component found naturally in the leaves of the plant, was effective at blocking the growth and spread of gastrointestinal cancer cells, suggesting that it could possess powerful cancer-fighting properties.

2. Sweet News for Diabetics

Due to the fact that they can be supportive of metabolic health, many experts now recommend zero-calorie sweeteners such as stevia for those with obesity, prediabetes and diabetes. A 2018 review published in the Journal of Nutrition concluded that using stevia instead of white sugar can be very beneficial to those with diabetes who need to follow a low-glycemic, diabetic diet plan.

A separate article published in Journal of Dietary Supplements evaluated how stevia may impact rats with diabetes. In the study, administering the sweetener to rats was found to significantly reduce blood glucose levels and increase insulin sensitivity, both of which can help defend against diabetes progression.

Another 2019 study in humans found that consuming stevia before a meal improved diabetic markers, such as by reducing blood glucose and insulin levels after eating. Additionally, although participants consumed fewer calories, they reported similar levels of satiety, and they didn’t compensate by consuming more calories later in the day.

3. Supports Weight Loss

Added sugar consumption contributes a large percentage of the total calories each day in the average American diet — and high intake has been linked to weight gain, obesity and other adverse effects on metabolic health.

For this reason, stevia is one of the most popular keto sweeteners and is also often used by those following other low-carb diets like the Paleo diet to add sweetness to recipes without contributing too many carbs.

A 2019 randomized control trial also found that “stevia lowers appetite sensation and does not further increase food intake and postprandial glucose levels. It could be a useful strategy in obesity and diabetes prevention and management.”

4. Helps Improve Cholesterol Levels

Some studies have found that stevia leaf extract could improve cholesterol levels and help keep your heart healthy and strong.

For example, a 2018 animal model found that administering stevia leaf extract to rats for eight weeks helped reduce levels of total cholesterol, triglycerides and bad LDL cholesterol, while also enhancing levels of “good” HDL cholesterol.

Similarly, a 2009 study showed that the extract had “positive and encouraging effects” on overall cholesterol profiles and effectively improved HDL cholesterol, decreased triglycerides and lowered levels of LDL cholesterol.

5. Can Lower High Blood Pressure

Certain glycosides in stevia extract have been found to dilate blood vessels and increase sodium excretion, both of which can help support healthy blood pressure levels.

One study in Clinical Therapeutics showed that consuming capsules with 500 milligrams of stevioside three times daily for two years led to significant reductions in systolic and diastolic blood pressure levels.

Keep in mind, however, that research on the potential effects of on hypertension has turned up mixed results, and some short-term studies have found no impact.

6. Unlikely to Cause Side Effects

While other natural sweeteners and substitutes often can cause digestive issues, a 2019 article published in Nutrients found that stevia is generally tolerated well and may even have beneficial effects on microbiota in the gut, elimination and glucose metabolism.

7. May Kill Lyme Disease

A 2015 study published in the European Journal of Microbiology & Immunology examined the effects of four forms of stevia: three liquid forms extracted from alcohol and a powdered form. Researchers found that while the powdered form didn’t show much, the liquid forms worked better than Lyme disease drugs and appeared to kill off the bacteria that causes lyme after seven days.

Is It Safe?

How safe is stevia? For most people, it can be consumed safely with minimal risk of adverse effects on health.

For instance, one study conducted in Paraguay found that consuming stevia daily for three months was well-tolerated and not associated with any negative side effects.

Highly refined and purified steviol glycosides are considered by the FDA to be safe when consumed as sweeteners in food. The FDA has also approved whole-leaf or crude stevia leaf extracts for use in dietary supplements.

Certain studies done in the ’90s found some evidence indicating that chronic administration could decrease the fertility of male animals and may affect hormones because its glycosides have a similar structure to plant hormones like gibberellin. However, many herbs, including ginkgo biloba, also have this natural component and are safe when consumed in moderation.

Side Effects

Why might stevia be bad for you? While it’s generally safe to consume, in some people, it may cause mild side effects, such as bloating, nausea, dizziness, numbness and muscle pain.

Certain products may also contain dextrin or maltodextrin, which can increase blood sugar levels in some.

Blends that contain sugar alcohols may also cause digestive issues in those who are sensitive. Common symptoms can include bloating, gas and diarrhea.

Additionally, stevia could potentially cause allergic reactions in people with an allergy to ragweed, as they belong to the same family of plants. However, this has never been reported nor studied in structured research.

How to Use

Stevia sweeteners are available online or at most local grocery stores, both in powdered and liquid form. Keep in mind: The best stevia has no additives, including other sweeteners, and should be USDA certified organic and non-GMO.

For green leaf (technically considered a supplement in the U.S., not a food), try Organic Traditions Organic Green Leaf Stevia Powder®. For a purified extract (the only food-approved type in the U.S.), SweetLeaf® Stevia is a popular choice, which is available in liquid and white powder forms.

You can also buy whole dried leaves and grind them at home, although it’s recommended you don’t use homegrown stevia for baking or cooking because of the chemical reactions that may occur.

Stevia leaf extract is available in both powders and liquid forms. The liquid varieties are useful for sweetening coffee, teas, healthy smoothies or natural stevia soda recipes. Powders work best for cooking and baking — and a little goes a long way.

Try these basic conversions the next time you replace sugar with this natural sweetener:

  • 1 teaspoon sugar = 1/2 packet or 1/8 teaspoon stevia powder = 5 stevia drops
  • 1 tablespoon sugar = 1.5 packets or 1/3 teaspoon stevia powder = 15 drops liquid stevia
  • 1 cup of sugar = 24 packets or 2 tablespoons stevia powder = 2 teaspoons liquid stevia

The only substitution that won’t work is caramelization in desserts, as it doesn’t brown like conventional sugar.

How It Compares to Other Sweeteners

Here is how stevia compared to other sugar substitutes:


Excess sugar consumption is associated with a slew of negative side effects, including heart problems, diabetes, liver disease and weight gain. In fact, just one teaspoon contains around 16 calories.

Stevia, on the other hand, is free of calories and has been linked to several potential health benefits, including decreased cholesterol and hypertension and increased insulin sensitivity.

Artifiicial Sweeteners

Aspartame is a common sweetener found in most diet sodas and many “sugar-free” foods. Although it’s free of calories, among those who are sensitive, it may also contribute to issues like indigestion and even depression and headaches.

Sucralose (also known as Splenda) is another popular sweetener that has been presented as a healthy alternative to aspartame since its approval in the 1990s. However, there are reports that sucralose may also be problematic, particularly because the body metabolizes it differently than most artificial sweeteners.

Sucralose has been thought to be safe in high-heat cooking, but a 2013 report reviewing the safety of this substance found that it generates toxins called chloropropanols when exposed to high temperatures. Another major difference between stevia vs. Splenda is that sucralose may negatively impact glucose metaoblism and insulin sensitivity.

Sugar Alcohols

To avoid artificial sweeteners, many people choose items sweetened with sugar alcohols (SAs), which are low-calorie sweeteners such as erythritol, xylitol, mannitol and sorbitol.

While these aren’t exactly the same as artificial sweeteners in their composition and don’t cause spikes in blood glucose, they are associated with digestive side effects like bloating, diarrhea and gas.

Another key distinction between SAs such as erythritol vs. stevia is that they are often extracted from genetically modified corn, which many people choose to avoid due to concerns about long-term safety.

Natural Sweeteners

Besides stevia, there are several other natural sweeteners that you can enjoy in moderation as part of a healthy diet.

In particular, raw honey, dates, coconut sugar, maple syrup, blackstrap molasses, balsamic glaze, banana puree, brown rice syrup and real fruit jam are all healthy sweeteners to consider using.

Keep in mind, however, that these do impact caloric intake and insulin release. However, they often provide important micronutrients and offer several health benefits as well.


  • What is stevia? It is a no-calorie sugar substitute derived from the Stevia rebaudiana Bertoni plant, which is native to South America.
  • Is stevia healthy? Some research shows that it may help lower cholesterol levels, support metabolic health, reduce weight gain and possibly provide some cancer-fighting compounds.
  • Although it adds lots of natural sweetness to recipes, it’s virtually free of calories and carbs. This makes it a popular choice for keto and other low-carb diets, such as the Paleo diet.
  • Not all stevia sweeteners are created equal. Some are highly processed or blended with other sweeteners, which can negate any of the potential health perks. Crude stevia is also still controversial according to the FDA when consumed in high amounts.
  • Be sure to opt for organic, green leaf stevia whenever possible, and check the ingredients label carefully to ensure you get the best bang for your buck.

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