Folate vs Folic Acid… 1 is Healthy and 1 is Dangerous

June 21, 2017
Folate Vs Folic - Dr.Axe

Folate vs. Folic Acid

What you’re about to read about folate benefits and folic acid side effects may surprise you! In fact, it may even surprise some doctors and nutritionists since folate and folic acid are used interchangeably.

The United States Public Health Service and Centers of Disease Control and Prevention recommend that, All women of childbearing age consume 0.4 mg (400 micrograms) of folic acid daily to prevent two common and serious birth defects: spina bifida and anencephaly.”

This is actually a pretty strong recommendation and you’ll be hard-pressed to find anything like this related to men’s health. In fact, folic acid is one of the very few vitamins and minerals that government health agencies have embraced so emphatically.

I find this shocking because the research out there seems conclusive; folic acid has been proven to be harmful to our health and has even been linked to causing cancer!

Folic Acid Side Effects

Folic acid is a synthetic B vitamin found in supplements and fortified foods. Curiously, mainstream media and government agencies use the term synonymously with folate, the natural form of multiple B vitamins commonly referred to as “vitamin B9.”

This has led the entire nation to believe that folic acid is a naturally occurring vitamin (which it isn’t), and that it’s healthy to supplement with (which it isn’t).

Unlike natural folates (which are directly metabolized by the small intestines), folic acid requires the assistance of a specific enzyme named “dihydrofolate reductase”, which is relatively rare in the body.

Subsequently, when people (particularly women of child bearing age) consume large amounts of folic acid through vitamins and other fortified foods, the body cannot break it down and elevated levels of un-metabolized folic acid ultimately enters the blood stream.

One of the dangers associate with this boost of folic acid in our systems is that it has been linked to cancer.

In her article published in the American Journal of Clinical Nutrition, Cornelia M. Ulrich from the Fred Hutchinson Cancer Research Center in Seattle, sums up the research nicely:

“Although increases in folate before the existence of preneoplastic lesions (such as aberrant crypt foci or polyps in the colon) can prevent tumor development, supplementation with synthetic folic acid may enhance progression once preneoplastic lesions are present.”

The perfect example of this can be seen in, an article published by the Journal of the American Medical Association (JAMA) in 2007.

A randomized controlled trial of nearly 1,000 people conducted over a three year period uncovered that supplementing with folic acid (1 mg/d) literally showed an increased risk of advanced cancer (multiple adenomas). In Ulrich’s words:

“These results suggest that the role of folate in fostering the growth of pre-cancerous cells is a real concern for humans at intakes that can be achieved with a combination of supplement use and fortification with folic acid.”

According to an article published in the Journal of Neurology, Neurology & Psychiatry, folic acid side effects can include:

  • Vitamin B12 deficiency
  • Epilepsy
  • Changes in sex drive
  • Lack of focus
  • Trouble sleeping
  • Emotional ups and downs

High Folate Foods

It is important to keep in mind that folic acid was relatively non-existent in our diet until being first introduced in 1943. After it was shown to help prevent the risk of developing neural tube defects in infants, it became part of the mandatory food fortification list in 1998.

Until then, humans received their vitamin B9 naturally in the foods that they ate.

The highest folate foods include:

  • Citrus fruits and juices
  • Dark green leafy vegetables
  • Liver
  • Soaked Beans
  • Poultry
  • Sprouted ancient grains

Here is an excellent chart listing out some of the best high folate foods… except for number 4 (breakfast cereal), which actually contains folic acid:

folate foods chart

To learn more about the Top 10 Folate Rich Foods check out this article.

Folate Benefits for Your Health

It has been shown that folate helps prevents several birth defects and promotes:

  • Adequate birth weight
  • Healthy neural tube formation
  • Proper development of the face and heart

Consequently, the recommended daily intake for folate during pregnancy is 600 mcg/d, which is roughly 50% higher than the non-pregnant recommendation of 400 mcg/d.

It’s important to note, however, that the pregnancy RDA is based on birth defect prevention, not on promoting health and wellness for a mom.

It is also based on the assumption that 50% of the folate ingested by Momma is absorbed.  Yet, studies have shown that this amount varies widely from person to person and other factors need to be taken into account, including zinc status.

In addition to pediatric concerns, adults can also suffer from folate deficiency.

Folate Deficiency Symptoms

Some of the warning signs you may have folate deficiency symptoms include:

  • Anemia
  • Canker sores
  • Diarrhea
  • Irritability
  • Fatigue/lethargy
  • Pale skin
  • Premature hair graying
  • Stunted growth
  • Tender, swollen tongue

It is important to remember, especially for pregnant moms, that folate is extremely easy to get by eating a well-balanced diet.

Make sure to load up the healthy foods I included above and if you’re concerned that you’re not getting enough, you can supplement with an all-natural green superfood powder or whole-food based multi-vitamin.

Are you consuming enough Folate rich foods? Did this news surprise you?

From the sound of it, you might think leaky gut only affects the digestive system, but in reality it can affect more. Because Leaky Gut is so common, and such an enigma, I’m offering a free webinar on all things leaky gut. Click here to learn more about the webinar.

Josh Axe

Get FREE Access!

Dr. Josh Axe is on a mission to provide you and your family with the highest quality nutrition tips and healthy recipes in the world...Sign up to get VIP access to his eBooks and valuable weekly health tips for FREE!

Free eBook to boost
metabolism & healing

30 Gluten-Free Recipes
& detox juicing guide

Shopping Guide &
premium newsletter



  1. Audrina @ Mindfully Audrina on

    Wow, thank you for this important information! Also, never thought folate played such a large role in our overall health. Definitely going to try to include more folate rich foods from now on!

  2. C. Darabi on

    Great info! Maybe you should have also included how a significant number of the population carry a MTHFR gene mutation that causes a defective methylation cycle and how important it is for them to consume folate from natural sources or a more active form instead of folic acid. Just a thought…I absolutely love your articles…just seemed like this info was missing.

  3. Judy Baker on

    Hi Dr. Axe,

    This is a very strong article. Women have been taking Pre Natal Vitamins for many many years and Folic Acid is given at high dosages. I have been purchasing Andrew Lessman Vitamins for many years and have both my daughters, who are approaching having children, on his prenatal vitamin. I have them only taking one a day. It has 400 mcg of Folic Acid per one vitamin. I also take one a day and I am 53. I use it as a multi vitamin! I like the small amount of iron in it.
    The article is not scary but very confusing because there is not a ob/gyn that doesn’t have their patients on a prenatal with high amounts of Folic Acid. I follow you each day! Honestly, it is hard trying to be healthy.
    Many experts, You, Dr. Oz, Andrew Lessman all have different research and opinions it truly gets confusing on which path to follow. I will keep trying to be healthy. Love your website and your goals.

  4. Melissa Dorrell on

    I have been told that I need to take 4 mg of Folic Acid a day because I have a genetic mutation called MTHFR. I’m not sure I could get enough Folate from food. What can I do?

    • Dr. Josh Axe on

      Take a quality supplement with folate. We have a new Vitamin-B Adrenal Complex supplement coming out for Axe Naturals in 2 months that will have it. For now, Megafood and Garden of Life supplements contain Folate.

    • Shannon on

      Do NOT take folic acid if you have this mutation. There are activated B complex vitamins you can take from as well as some other websites (like the one listed by Dr. Axe). Try to learn as much as you can since this mutation can have a big impact on your health if it is expressing. One place to start is There are also online support groups that have tons of info. Good luck!

  5. JEP on

    Hi Dr. Axe,

    After having genetic testing my Dr. has prescribed Methylfolate. How do you feel about that supplement? Can taking 15mg per day be too much? Thanks. :)

  6. Rhoda w on

    Are there any B vitamins that you know of that don’t have folic acid ?thanks for being our watchman on the wall.

  7. Andrew on

    Dr Axe based on the research in this article, would you personally recommend that we should stop taking supplements with folic acid in them and get folate naturally through foods

  8. Elizabeth Battaglia on

    Dr. Axe, I am currently on a chemo drug called Alimta and have been ordered to also take 400mcg of Folic Acid daily. Can I substitute the same amount of Folate instead?

  9. Russ Wick on

    I have to take Warfarin daily to prevent clots from vericose veins and varicular insufficiency. I also have material fib. What can I take to assure adequate vitamin k and folic acid levels.

Comments are closed.

More Posts