L-Glutamine Benefits Leaky Gut & Metabolism

Have you heard about the incredible health benefits of L-glutamine? 

First used in powder form by people in the fitness industry who were looking to preserve muscle tissue, L-glutamine is an amino acid that is a building block of protein.

L-glutamine is the most abundant amino acid in the bloodstream and it makes up 30-35 percent of the amino acid nitrogen in your blood. It’s actually known as a conditionally essential amino acid because your body uses it in large amounts.

The most common uses of glutamine powder were to meet the following goals: to lose weight fast, burn fat and build muscle. And while that remains the case, science is now showing that L-glutamine benefits are abundant – and that this amino acid is especially helpful in treating leaky gut and improving your overall health.


L-Glutamine At a Glance

  • An essential amino acid needed by your body in large amounts
  • Promotes digestive and brain health, muscle growth, athletic performance, and more
  • Fights cancer and high blood sugar
  • Found in both animal proteins and plant proteins
  • Available in supplement form (see below for dosage instructions)

10 Proven L-Glutamine Benefits

New research is now showing that L-glutamine benefits the body in the following ways:

  1. Improves gastrointestinal health because it is a vital nutrient for the intestines to rebuild and repair (1)
  2. Helps heal ulcers and leaky gut by acting as a Band-Aid for protection from further damage (2)
  3. Is an essential neurotransmitter in the brain and helps with memory, focus and concentration (3)
  4. Improves IBS and diarrhea by balancing mucus production, which results in healthy bowel movements (4)
  5. Promotes muscle growth and decreases muscle wasting (5)
  6. Improves athletic performance and recovery from endurance exercise (6)
  7. Improves metabolism and cellular detoxification (7)
  8. Curbs cravings for sugar and alcohol (8)
  9. Fights cancer (9)
  10. Improves diabetes and blood sugar (10)

 

L-glutamine benefits - Dr. Axe

 

Let’s look at a few of these incredible L-glutamine benefits more closely….


L-Glutamine Heals Leaky Gut and Improves Immunity

There are millions of people struggling with a condition called leaky gut syndrome, which is essentially the main cause of autoimmune disease today. Leaky gut can cause thyroid issues like Hashimoto’s disease, and also contributes to arthritis, skin issues like psoriasis and other serious health issues.

Because glutamine is the major fuel source for cells of the small intestine, it has been shown to heal leaky gut in clinical studies. A study published in the medical journal Lancet examined 20 hospital patients and found that supplementing with L-glutamine decreased intestinal permeability. And an animal study published in the British Journal of Surgery found that L-glutamine benefits ulcerative colitis and inflammatory bowel disease.

If you’re unsure if you suffer from leaky gut, take my leaky gut test. If, indeed, you appear to have leaky gut, L-glutamine is the number one amino acid you need to help heal and repair it. In fact, L-glutamie is one of my top three most recommended supplements overall for treating leaky gut and/or building a lean body.

Bottom line? L-glutamine benefits your health if you have any type of digestive issue, such as irritable bowel syndrome (IBS), an inflammatory bowel disease like Crohn’s disease, ulcerative colitis, diverticulosis, diverticulitis, leaky gut or any of the issues associated with leaky gut (like joint pain, rosacea or any type of autoimmune response). And you need this amino acid in your diet on a regular basis. 

So for example, if you have Hashimoto’s or an underactive thyroid, L-glutamine should be a part of your hypothyroidism diet. If you suffer from IBS symptoms like constant diarrhea or ulcerations, L-glutamine needs to be part of your IBS diet.

It’s worth noting that the man famous for discovering the Krebs cycle in the body (also known as the “citric acid cycle”) was the first person to recommend taking L-glutamine for gut-related issues. That’s because he found that it helped improve a healthy gut-related immune response. And additional research supports this finding.

A medical study published in 2001 found that L-glutamine benefits the body by regulating IgA immune response. IgA is an antibody that attacks viruses and bad bacteria. (It’s also  associated with food sensitivities and allergies.)

Another study published in the journal of Clinical Immunology found that L-glutamine normalizes the effects of the TH2 immune response that stimulates inflammatory cytokines. (11)

The effects of L-glutamine in these studies prove that L-glutamine reduces intestinal inflammation and can help people recover from food sensitivities.


L-Glutamine Improves Energy and Athleticism

One of L-glutamine’s main roles in the body is to support detoxification by cleansing the body from high levels of ammonia. It acts as a buffer and converts excess ammonia into other amino acids, amino sugars and urea. (12)

Doing approximately one hour of exercise can cause a 40 percent reduction of glutamine in the body. It can also cause suppressed immune function. This has a negative impact on your resistance training and may lead to overtraining syndrome. (13)

L-glutamine benefits long distance athletes as well by boosting the immune system (T-helper cells). Animal studies have indicated that this increase in T-helper cells may reduce the ‘stresses’ associated with overtraining syndrome. (14)


L-Glutamine Benefits Bodybuilding

Whether your goal is to increase athletic performance, boost metabolism, improve recovery or even build muscle, research shows that L-glutamine is a must-have supplement.

During an intense workout, your body becomes stressed and your muscles and tendons require more glutamine than the amount supplied by a normal diet.

So, after an intense workout the levels of cellular glutamine can drop by 50 percent and plasma levels by 30 percent! This muscle-wasting state is a gateway for the body to use your muscle for energy rather than carbohydrates. But glutamine can prevent this from happening. (15)

Supplementing with L-glutamine allows your muscles to fight and push a bit further, which boosts your strength and helps repair your skeletal muscles.

A study found that L-glutamine supplementation makes it possible to recover quicker from intense weight training sessions because it improves muscle hydration. (16) This aids the muscle recovery process and reduces recovery time for wounds and burns. (17)

Replenishing glutamine levels after an intense session could take up to five days, so it is important to take it on a regular basis if you are doing intense exercise.


L-Glutamine Burns Fat and Boosts Metabolism

A study reported that glutamine also helps with human growth hormone secretion (HGH). This aids with fat metabolism and supports new muscle growth.

Research has indicated that HGH levels are up by nearly 400 percent after supplementing with L-glutamine. This hormonal response leads to an increase in resting metabolic rate and improves the after-burn effect or EPOC post exercise. This after-burn effect is essential for burning fat, weight loss and building lean muscle mass. (18)

L-glutamine also burns fat and builds lean muscle mass by helping suppress insulin levels and stabilize blood glucose. This enables the body to use up less muscle mass to maintain blood sugar and insulin sensitivity in the cells. For this reason, L-glutamine benefits diabetics and those with sugar and carb cravings as well. (19)


Foods with L-Glutamine Benefits

With 70 million Americans now suffering from digestive diseases, it’s apparent that our diets are severely lacking certain nutrients that support the digestive tract. While L-glutamine is synthesized by the body from glutamic acid or glutamate, sometimes the body is unable to produce enough. And when this is the case, your body needs to get it directly from your diet.

L-glutamine is synthesized by the body from glutamic acid or glutamate. If the body is unable to produce enough it needs to get it directly from your diet.

L-glutamine can be found in animal proteins such as meats and dairy, along with plant-based protein sources such as beans, raw spinach, parsley and red cabbage. It’s worth noting, though, that animal proteins are not as easily digestible as plant proteins.

The foods with the most L-glutamine benefits include:

1. Bone Broth

2. Grass-fed Beef

3. Spirulina

4. Chinese Cabbage

5. Cottage Cheese

6. Asparagus

7. Broccoli Raab

8. Wild Caught Fish (Cod, Tuna and Salmon)

9. Venison

10. Turkey

I recommend consuming at least three servings of these L-glutamine-rich foods daily.


L-Glutamine Supplements and Dosage

It’s important to know that the majority of people don’t get enough L-glutamine from their food alone. That’s why supplementing your diet with L-glutamine is an excellent way to boost your immune system and improve your ability to fight infection and diseases.

Amazingly, around 60% of your skeletal muscle is made up of glutamine – and supplementing this amino acid can aid protein synthesis and help naturally balance your pH levels.


Types of L-Glutamine

There are two forms of L-glutamine. You can get regular L-glutamine in what’s called its free form, and it should be taken with food ideally for proper absorption by the body. The other type of L-glutamine is called Trans-Alanyl or Alanyl-L-Glutamine — it’s an amino acid attached to another amino acid, which basically means you’re going to digest it much better. Unlike free-form glutamine powder, you can take it on an empty stomach.

But both forms of glutamine powder are best taken right after or right before workouts — with your small meals right before or after workouts for it to support your metabolism and weight loss as well as for muscle building, recovery and preservation.


How Much to Use

Typically, the best dosage is between 2 to 5 grams twice daily, and up to 10 grams daily for serious power athletes. Although the effects of excess glutamine rarely cause problems, if you are taking L-glutamine long-term, it’s a good idea to also supplement with B vitamins. This especially applies to vitamin B12, which controls glutamine buildup in the body.


Final Thoughts on L-Glutamine Benefits

Whether you’re looking to increase your athletic performance, build muscle or improve a health condition such as leaky gut or diabetes, L-glutamine should be a part of your daily diet. Make it your go-to supplement, and it likely won’t be long until you start to feel the difference.

Read Next: Turn On Your Fat Burning Switch with Ghrelin & Leptin


From the sound of it, you might think leaky gut only affects the digestive system, but in reality it can affect more. Because Leaky Gut is so common, and such an enigma, I’m offering a free webinar on all things leaky gut. Click here to learn more about the webinar.


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  1. Lori says:

    My son was diagnosed with ulcerative colitis 6 months ago. He is currently taking Lialda, Canasa, and 5 mg of Prednisone each day. He has responded pretty well to treatment, but ideally we would like to treat him as naturally as possible. Would you recommendl-glutamine for him? If so, at what dose? He is 5’2″ and weighs 110 lbs. Thank you!

  2. Cinnamon says:

    Thank you Dr.Axe! Once again a perfectly timed article on the topic I’ve been researching ;)
    What do you think of Litdke brand? http://www.amazon.com/gp/aw/d/B001E2IRH6?pc_redir=1407162633&robot_redir=1

  3. Catherine King says:

    I have a little girl who is 38 lbs with terrible leaky gut syndrome (along with an ASD diagnosis). We are on Specific Carbohydrate Diet and I want to add this supplement in. We tried it in the past with no real noticible differences. How should I re-introduce and which is the best kind?

  4. Teri Grisler says:

    I have been taking l glutamine since I read the article that Dr. Axe shared last spring about healing the gut. I had chronic eczema and once I started with the recommendations from the article, including the l glutamine, my problem has been under control. I don’t do all that was recommended like the bone broth but I do try to do all when I can. The l glutamine is something that I have done consistently and I still have had great results of my eczema. I do still have adult acne but am working on that now by doing some candida and parasite cleanses. Thank you Dr. Axe for all of your knowledge and sharing it with all of us with problems!

  5. Susan Edwards says:

    I would like to ask if milled flax sunflower pumpkin & Gogi berries are good for you is there any side effects
    Thanks miss Edwards

  6. Sara says:

    Hello. It’s also important to note potential side effects of glutamine. First of all, i have read it can be converted into glutamate in the brain, of which, mine was already too high. Second of all, it caused me terrible gas, constipation, and abdominal cramping. Maybe some are more sensitive than others. Hope it works positively for others.

    • That’s a rare experience but with any food or supplement you can have a reaction. I’ve used this with thousands of patients and have not seen any adverse reactions but again, if someone is sensitive, they can be allergic to healthy foods and supplements. One thing to consider is starting in smaller amounts of 100mg and working your way up.

  7. cosmin says:

    According to “Examine.com” glutamine has not been proven to enhance muscle building in healthy individuals.
    Only those suffering from physical trauma such as burns or muscular wounds (knife wounds) or in disease states in which muscle wasting occurs, such as AIDS. In these individuals, however, glutamine is effective at building muscle and alleviating a decrease in muscle mass typical of the ailment.

    • This has been used in the fitness/bodybuilding industry and in endurance athletes for years. These individuals are very in tune with their bodies and after interviewing many of them, they believe they have seen results from supplementing with L-Glutamine. You might be right in that there is not one direct study that shows it helps with bodybuilding but there are many good studies that I quoted that show that it does prevent over training which long term, should correlate with more muscle growth.

  8. Anna says:

    We are doing GAPS and having trouble getting bone broth in my 2 highly food allergic/eczema boys. Would the dosing you listed be the same for kids?

  9. Kitty Hagner says:

    How long do you recommend taking l-glutamine for leaky gut?

    • I personally take it every day, 2x daily for health benefits! If you’re looking to take it just to help support healing of leaky gut I would try it for 3 months and then reevaluate.

  10. Melody says:

    I came across this article by Dr. Mercola. I am confused by disagreeing suggestions. Could you help clarify? Thank you so much for all you do in regards to helping so many with their health.

    http://articles.mercola.com/sites/articles/archive/2004/05/01/glutamine.aspx

  11. MINNIE DAVIS says:

    Hello Dr. Axe:

    Do you keep office hours? Is there a telephone where you can be reached for consultation?

  12. Cindy says:

    Does it matter if it’s beef or chicken in the bone broth for gut healing?

  13. Diane says:

    I am currently taking Great Lakes collagen, would I also benefit taking L-glutamine as well?

  14. Merle says:

    Can I take it while breastfeeding?

    • It shouldn’t be an issue. It’s an amino acid present in meats and plant based proteins. Always make sure to read the label beforehand and follow the instructions.

  15. Laurie says:

    Does this supplement have any effects positive for negative for gall stones. I would like to start taking this with some other supplements for Sarcoidosis and Hypothryroid but dont want to upset my gall bladder. Thanks

    • It shouldn’t be an issue. It’s an amino acid present in meats and plant based proteins. Always make sure to read the label beforehand and follow the instructions.

  16. JE says:

    I just heard about this from a woman working for Vitamin World. She’s taking it and said she’s seen results.
    Is there a certain brand of L-Gultamine you should take.

  17. Rhonda says:

    I was wondering if I eat fermented foods, drink water kefir, eat ginger, coconut oil. eat clean as I can (daily) do I still need to take a probiotic with the glutamine?

    • It depends on many different factors including the state of your gut and whether or not you have leaky gut, how severe it is, how many food intolerances you may have, your health goals, etc. Also, there are many different types of probiotics. The ones present in your food may be different strains than the ones in a supplement. I personally do both.

  18. mary says:

    Is this also a good supplement for Diverticulosis? What else would you suggest ? Thanks in advance Dr. Axe!

  19. Mike says:

    Hi..thanks for a great article. I’m pretty sure I have leaky gut as my GP said that I have proteins circulating in the gut. I also have a compromised immune system. I was wondering if you know much about Kefir & weather you think that might help? I will also start supplementing with L Glutamine as I work out regularly & feel pretty tired a lot if not most of the time… Thanks again ;)

  20. Mike says:

    Thanks for that ;) One other question . Do you think that Paleo is generally the healthiest diet to follow. I have just ordered a book by Chris Kresser which seems like a really sensible approach ? Thanks

  21. Mike says:

    Thanks heaps ;)

  22. JE says:

    Should you take an enzyme with a probiotic? I’ve been drinking Kefir “brand from trader joe’s”. Are you familiar with their brand? Can you take L-glutamine while on iron or any diuretic.

    • If you have a digestive issue, it makes sense to take a digestive enzyme as well. You should have no issues taking L-glutamine while on iron or a diuretic.

  23. Jackie says:

    Do you think that this would be safe and effective to supplement for a 12 lb. dog with IBS? (vets are even more resistant than medical docs for trying natural ‘remedies’ IMHO)

    • I don’t know how safe it would be for dogs to consume the glutamine, I will look into it. I would check the food you are giving your dog to make sure it is whole, grain free, without fillers and high in good protein. You might consider giving the dog small amounts of kefir which could help his gut.

  24. rachel says:

    Hi Dr Axe, I just wanted to ask if the 5gm of glutamine twice a day is based off clinical studies, or is this amount what you have found most effective in your clinical practice. Thanks for all the great info that you produce.

  25. Julie C says:

    Thanks for the great information and recipes provided in your emails.

    Julie

  26. Sue says:

    I was diagnosed with CFS due to having Epstein Barr Virus several years prior. Continue to have
    ” energy crashes” and other issues that go along with CFS. Also had current test showing high oxidative stress. Would it be beneficial to take
    l-glutamine? Thank you so much for the information. Blessings

  27. Beth says:

    How do you know if you have leaky gut? Do you need to be diagnosed with it by a doctor? I have psoriasis — have had it for 35-40 years. Its been worse in my adult years — especially over the past year or two. I’m not 47. Is this something I need to try?

  28. Lise says:

    I’ve recently stumbled across your site and am finding such a positive wealth of information! About a year and a half ago, my daughter was diagnosed with leaky gut and a host of food sensitivites. In this time, we have worked really hard to eat clean, lots of healing foods. (Grass fed beef, green vegetables, probiotic foods, nuts, etc) She has been pretty much symptom free (eczema) for about six months. I just started adding in great lakes gelatin into our diets (smoothies and home made jello. ) Would this be a good source of l glutamine? Or do you think a supplement is necessary.

  29. Brenda says:

    I am interested in knowing how you take the powder with a meal.

  30. Mike says:

    Hi again…I re read my post & realised I meant to say proteins circulating in the blood…not gut…but gather you understood what I meant anyway lol ;)

  31. Kristin says:

    How can you take your L-Glutamine powder if you are not adding it to a protein drink? Mix with water & drink??

    • Exactly! It doesn’t take much water for it to dissolve so it’s really easy to drink. If you wanted, you could also add it to a veggie juice or coconut water or something with a little flavor.

  32. Lisa says:

    In 2009 my stomach had severe pain, to where I was afraid to eat (imagine!) After a dr. confirmed the stomach lining (mucosa) had been compromised… likely due to NSAIDS, I read that beta-carotene helped stomach lining, drank carrot juice and pain was relieved. I also read about Glutamine and have been supplementing with it, although at much lower levels than you recommend. From this article I am going to step up daily intake closer to your recommendation although I have capsule form and will be more difficult. Recently I read articles about Atrophic Gastritis. I believe this is an explanation for what happened to me, and is the “technical” term for leaky gut. I match the description, having Hashimoto’s dx in 2008. Twice it’s found I have no H Pylori, so I conclude it was the autoimmune cause. Also pre-cancerous spots found in my stomach during endoscopy, matching the description of the condition – now I am in high gear focusing on repairing stomach. Recent IgG tests show no allergy to wheat or gluten, but to brewer’s yeast! It is a long, expensive road getting to inflammation causes. Thanks for articles on causes and treatments, as no doctor I’ve had has been able to do that.

  33. SharonC says:

    I saw that you take the powder can you recommend a capsule?

  34. Lorrie says:

    I recently started taking the Motiff Amino Starter for stomach issues (the doc thinks it’s minor gastroparesis) This is my second day. I take one scoop in 16oz of water with some berries thrown in for sugar. But I notice that when I drink it, I get a dizzy…. almost drunk feeling. Is this normal when starting out a supplement like this?

    Thank you!

  35. lorraine says:

    Hi, may I first thank you for all the amazing help you give us. At my age (in my seventies) its been quite a thing to go natural, but this gutsy ol’ lady takes on anything!
    I was wondering seeing that I make and drink Kombucha and kefir grains every day, would that be sufficient to keep the gut bacterias behaving themselves?
    Thanks again and blessings from South Africa.

    • That’s great! But when consuming probiotics you want a lot of different strains so I would try to incorporate fermented foods that are rich in probiotics in addition to what you’re consuming.

  36. JR says:

    I was told I had fatty deposits in my organs I’m assuming there’s absorption issue in my body. Does this means leaky gut? I have been drinking warm lemon water to cleanse my liver. Is there a L-glutamine i can pick up at a health store..now. I make my own smoothie in the morning with spinach, kale, blueberries,kefir, sometimes, apple cider vinegar, aloe juice and kombucha. Does that sound pretty good. I just want to have my gut not feel like something moving inside.
    One last thing, how can you get rid of fibroid(sp?) naturally.

    Thank you for responding to our questions, most professionals don’t. but I see it’s not about the money but about helping people feel better.

  37. lorraine says:

    Hi, I might just add, I have major allergies including most of the anti biotics, have no gall bladder no thyroid use eltroxin, severe asthma severe arthritis osteo, in a wheel chair, and an ulcer. Battle terribly with Rosacea (actually experimenting with magnesium oil spray with a few drops of lavender!) As I mentioned above I am in my seventies and not a happy camper, also cannot go out and buy a million supplements to help me. Also had glandular cancer many years ago, lost my daughter to breast cancer 12 yrs ago and she was only 35! So absolutely any help that I may be able to afford would be awwsimmmmmmmm! Forgot to mention the hypertension,. I am so sick and tired of all the medications and the anti-depressants, lost my hubby to Parkinsons.
    Its difficult to believe I was a South African Gymnast, and ballet dancer for 20 years. Blessings

  38. George Stuart says:

    came across the video on resistance band exercises and when I went to return to watch it could not find it .Have searched the website high and low and still have not found it . Can you please tell me how to get to it

    Many Thanks

  39. Christian Behrens says:

    I’m training for a marathon, I’m right now in the peaks weeks (80-100km x week). How, how many and when can I use L-Glutamine?? Thanks a lot for your help!!

  40. ghada says:

    hi dr Axe ,Iam suffering from h.pylori along with parasites what should i do if i dont want to take all the antibiotic the doctor gave me , i prefer to treat it naturally , i fell pain and bloating in my stomach .

  41. ghada says:

    Hi Dr Axe ,I am taking manuka honey for more than two months with apple cider vinegar and 3 cloves of fresh garlic 2x a day but still in pain should i switch to your protocol to kill that bad bacteria , i read about oregano oil and other essential oils are they safe to take internally and about mastic gum please need your advice ,i will try my best not take the antibiotic ,i hope i will success .

  42. ghada says:

    thank you so much Dr Axe for your help and reply ,at least i know that i am doing right ,I will continue , i want to ask you about bone broth can replace l-glutamine and if it is the normal one we do it for cooking or has specific ingredients .

  43. Cheryl says:

    Approximately how many teaspoons would 5 grams be?

  44. kim says:

    I read somewhere that taking b12 with the l glutamine will help with build up with the product is this true if so how much b12 do I take ty so much

  45. Islam says:

    Dr. Axe many thanks for your opinion and great informative articles you publish. With regards to L-Glutamine Supplementing, what do you think of Glutamine tablets like GNC Glutamine tablets? And also, what would you recommend for Paleo Nutrition enthusiasts when eating natural food sources for Glutamine, apart from Raw cultured Dairy sources?

    Many thanks and all the best!

  46. Christa says:

    I have always read that glutamine should NOT be taken with a meal that contains protein, as it has to compete for absorption with the other amino acids. Therefore it should be taken on an empty stomach. You have recommended to take glutamine with food. Is there a particular reason for this?

    Thanks!

    • It may compete with others but food helps increase glutamine absorption overall, regardless. I am coming out with a leaky gut supplement that will be tied to an amino acid so that it does not have to be taken with food in order to reach full absorption potential.

  47. gary malcik says:

    stomach lining and L glutamine

  48. Kaye says:

    Hi Dr. Axe,
    I have been taking l-glutamine long term, for over a year per a nutrition coach…2 grams, 3 x daily. Since July, I have had this mystery edema occuring only in my legs. I am super-healthy and eat super-healthy, labs point nowhere, and can’t seem to attribute this to anything else. Could my long term use of l-glutamine be the cause?

    • I’ve never heard of it having this type of effect so I don’t think that would be the culprit. I would try to get a little more movement in throughout the day and not sit or stand for long periods of time.

  49. Anh says:

    Hi Dream.Axe, I’m currently taking 3 different medications for high blood pressure. If I take L-Glutamine, is it going to raise my blood pressure. Thank you.

  50. Amy says:

    Is it okay to take the tablets instead of powder? If, no – why not? Thx!

  51. Connie Markley says:

    Is there any connection with MSG?

  52. Denise Herrera says:

    Is this safe to take during pregnancy?

  53. nancy says:

    My local heal food store highly recommended this to me last Saturday also, but I was at my limit financially, so I didn’t buy it.
    We are on a very tight budget and just don’t have the $42 to buy the one you use.
    Can you suggest a less expensive brand?
    I’m almost 62 and have been a T1 Diabetic for over 46 years and have had digestion issues since before then.
    Thx for any recommendations.
    Happy Thanksgiving to you all!

    • Rose says:

      Powder city.com sells it in bulk powder, they ship free and also have a 10% off coupon. 1 kilo approx. $ 27.00. That’s a lot of L Glutamine.
      Good Luck, Rose !

    • Greg says:

      Search the internet for deals and buy it in powder form that is cheaper. I just bought some a while back and it wasn’t anywhere near $42. Hope this helps.

  54. Jill Nau says:

    Would glutamine interfere or be bad to take with any medications?

  55. Krissy says:

    I’ve tried L-Glutamine but get sinus inflammation/migraines every time (my default reaction). Same with bone broth. I am sensitive to almost everything I eat so eat AIP and take entirely too much silver just to get by. I believe it’s leaky gut but all the best healers make me sick. Any other suggestions? Glutamine sounded like it would be the thing to fix me, but no dice. (Hashimoto’s for 15 years and hypothyroid before that, Reynaud’s syndrome, fatigue, brain fog, constant sinus battles, pain, neuropathy in all limbs and lately numbness in face) Thank you.

  56. Laura says:

    Dr. Axe – I have Pure Encapsulations brand of L-Glutamine capsules and had been taking 1g/day until I read this article. Am trying to heal a leaky gut so planned to work my way up to 5g twice a day. Took 4g the other morning and within 2 hours was doubled over with vomiting and diarrhea. Obviously I need yo back off on the dosage, but I have to say, the reaction scared me given how safe this supplement is supposed to be. Can you tell me why I might have experienced that reaction and how I might titrate the dosage in the future (assuming I am brave enough to try again!)

  57. Teacher Randall says:

    Hey Dr. Axe you can’t do this, this is the internet. A website with actual research cited for claims made is breaking the unwritten rule of the internet. All articles must make at least ten claims per one citations, and that citation must be to another website which must have another website as its source never reaching an actual research paper. lol

    but besides that great job! :D.

  58. Karen says:

    I read in a magazine article recently that glutamine can help with weight loss. Is this true?

  59. Laura says:

    Hi Dr. Axe – sure hoping you see this; I can’t seem to find an answer to this question: I had been taking just 1g of l-Glutamine and wasn’t notcing anything so did some research about dosages. Found your blog among others that suggests it is quite safe at higher doses, say 3-5g 2-3 times per day. So one day recently I took 4g on an empty stomach, followed by a smoothie about an hour later. Two hours after taking the supplement I was doubled over with diarrhea and vomiting. It was very alarming. Obviously that dose didn’t work for me, but what I wish I knew is what might be going on in my gut to have caused this reaction? Lastly, how would you recommend I titre my doses in the future? Thanks so much!

    • If you feel that 1g is doing nothing, try increasing to 1.5g slowly and see how your body does over a period of time. If it tolerates it well, after a week or 2, try adding another .5g

  60. Kristina says:

    Hi Dr. Axe, i have been trying to heal my gut since July 2014, i have cut out grains, gluten, soy, wheat but still eat some dairy. I have also been taking 3-7 HCL pills depending on the meal I am eating. I take a propiotic every day in the AM and take oil of oregano once at night. i just received my NOW brand powder L-Glutamine and i had read to take 40g a day so last night I had 10g in a smoothie before supper. After supper I had another 10g in some juice. This morning I had 10g more in some water with some fruit. It’s lunch time so I was about to have 10 more grams. Now I read this and I am starting to worry about how much I’ve taken! I wonder why there is such a discrepancy on what sites recommend. If i am fine taking 40g a day should I continue or no? I am 5’5″ 115 lb femaie.

  61. Lisa H says:

    How do I find a Dr. in my area that treats like Dr. Axe does? Is it Fundamental Medicine? I need a Dr. who specializes in an auto-immune hyper-thyroid condition. I am in the Seattle, WA area.

  62. Christine says:

    I am trying to heal up a leaky gut, but when I tried glutamine (5g once a day) I had the worst constipation I have ever had. (Similar effect with high quality gelatin – I don’t have the time to make bone broth.) I tried adding a stool softener, adding pectin for soluble fiber, lots of water, etc. and I already take a probiotic, but the only thing that helped was a laxative – not fun! Is there any way to take this stuff to avoid severe pain and a non-working digestive tract?

  63. Michelle says:

    I have just purchased a few supplements that you suggest for leaky gut (Qucertin, Licorice Root, Papaya Digestive Enzymes, etc.) but since I’ve never taken L-Glutamine before and you suggest powder if this supplement dosage would be fine? Its 1500 mg’s in capsule form? Also how long should you remain on these supplements to repair gut health?

    Dietary Supplement•1500mg Dose to Prime Muscles for Workouts
    •Provides Anti-Catabolic Effects & Supports Muscle Function
    •Supports Faster Recovery After workouts
    Glutamine is one of the most abundant amino acids found in muscles. It is involved in protein synthesis and plays an important role in hydrating muscle cells. With this amino acid’s great benefits in the body, it will support muscle function.

  64. Sharon GoddardWa says:

    Want to make sure L Glutamine is ok for type 1 diabetic.

  65. Scarlett says:

    Quite shocked and very disappointed that this article doesn’t discuss side effects to taking L-Glutamine. I had severe side effects, including insommnia, loss of appetite, and (bizarrely) a fear of going out and confronting problems/Iissues that arose with other people. I mentioned these symptoms to a friend and she had exactly the same experience. Both pf us were taking the supplement prescribed by our respective naturopaths. I’m disappointed because I expected to read more responsible advice than has been given here. People should be helped to become aware of the detrimental effects of supplements as well. This is a very powerful supplement and needs to be respected.

  66. Sharon says:

    Hi Dr Axe

    Is L-Glutamine safe when pregnant and breast feeding?

    Thanks :)

  67. Amy says:

    Very well written and informative article. My son has multiple food allergies and I spend a good amount of time researching natural healing options for him. This seems like a great option. But I must say I am confused. In my research I have run across doctors who claim that foods high in glutamate should be avoided. Why are there so many differing opinions? eg

  68. Betty Jo Woodcock says:

    I have peripheral neuropathy, which is quite painful. Also have Charcot’s foot on the left. A friend suggested L-Glutamine Powder. I have taken it 3 times a day for only one day. So far, the foot pain has decreased and I hope that it is due to the powder. Any suggestions would be appreciated.

    • I would look for a maximized living chiropractor in your area and also check this out:
      You may also benefit from a vitamin B12, omega d3 supplements and a diet higher in fat and low in sugar

  69. Denise Marie Hardman says:

    Does L-Glutamine help to reduce the symptoms of Restless Leg Syndrone?

  1. Lori says:

    My son was diagnosed with ulcerative colitis 6 months ago. He is currently taking Lialda, Canasa, and 5 mg of Prednisone each day. He has responded pretty well to treatment, but ideally we would like to treat him as naturally as possible. Would you recommendl-glutamine for him? If so, at what dose? He is 5’2″ and weighs 110 lbs. Thank you!

  2. Cinnamon says:

    Thank you Dr.Axe! Once again a perfectly timed article on the topic I’ve been researching ;)
    What do you think of Litdke brand? http://www.amazon.com/gp/aw/d/B001E2IRH6?pc_redir=1407162633&robot_redir=1

  3. Catherine King says:

    I have a little girl who is 38 lbs with terrible leaky gut syndrome (along with an ASD diagnosis). We are on Specific Carbohydrate Diet and I want to add this supplement in. We tried it in the past with no real noticible differences. How should I re-introduce and which is the best kind?

  4. Teri Grisler says:

    I have been taking l glutamine since I read the article that Dr. Axe shared last spring about healing the gut. I had chronic eczema and once I started with the recommendations from the article, including the l glutamine, my problem has been under control. I don’t do all that was recommended like the bone broth but I do try to do all when I can. The l glutamine is something that I have done consistently and I still have had great results of my eczema. I do still have adult acne but am working on that now by doing some candida and parasite cleanses. Thank you Dr. Axe for all of your knowledge and sharing it with all of us with problems!

  5. Susan Edwards says:

    I would like to ask if milled flax sunflower pumpkin & Gogi berries are good for you is there any side effects
    Thanks miss Edwards

  6. Sara says:

    Hello. It’s also important to note potential side effects of glutamine. First of all, i have read it can be converted into glutamate in the brain, of which, mine was already too high. Second of all, it caused me terrible gas, constipation, and abdominal cramping. Maybe some are more sensitive than others. Hope it works positively for others.

    • That’s a rare experience but with any food or supplement you can have a reaction. I’ve used this with thousands of patients and have not seen any adverse reactions but again, if someone is sensitive, they can be allergic to healthy foods and supplements. One thing to consider is starting in smaller amounts of 100mg and working your way up.

  7. cosmin says:

    According to “Examine.com” glutamine has not been proven to enhance muscle building in healthy individuals.
    Only those suffering from physical trauma such as burns or muscular wounds (knife wounds) or in disease states in which muscle wasting occurs, such as AIDS. In these individuals, however, glutamine is effective at building muscle and alleviating a decrease in muscle mass typical of the ailment.

    • This has been used in the fitness/bodybuilding industry and in endurance athletes for years. These individuals are very in tune with their bodies and after interviewing many of them, they believe they have seen results from supplementing with L-Glutamine. You might be right in that there is not one direct study that shows it helps with bodybuilding but there are many good studies that I quoted that show that it does prevent over training which long term, should correlate with more muscle growth.

  8. Anna says:

    We are doing GAPS and having trouble getting bone broth in my 2 highly food allergic/eczema boys. Would the dosing you listed be the same for kids?

  9. Kitty Hagner says:

    How long do you recommend taking l-glutamine for leaky gut?

    • I personally take it every day, 2x daily for health benefits! If you’re looking to take it just to help support healing of leaky gut I would try it for 3 months and then reevaluate.

  10. Melody says:

    I came across this article by Dr. Mercola. I am confused by disagreeing suggestions. Could you help clarify? Thank you so much for all you do in regards to helping so many with their health.

    http://articles.mercola.com/sites/articles/archive/2004/05/01/glutamine.aspx

  11. MINNIE DAVIS says:

    Hello Dr. Axe:

    Do you keep office hours? Is there a telephone where you can be reached for consultation?

  12. Cindy says:

    Does it matter if it’s beef or chicken in the bone broth for gut healing?

  13. Diane says:

    I am currently taking Great Lakes collagen, would I also benefit taking L-glutamine as well?

  14. Merle says:

    Can I take it while breastfeeding?

    • It shouldn’t be an issue. It’s an amino acid present in meats and plant based proteins. Always make sure to read the label beforehand and follow the instructions.

  15. Laurie says:

    Does this supplement have any effects positive for negative for gall stones. I would like to start taking this with some other supplements for Sarcoidosis and Hypothryroid but dont want to upset my gall bladder. Thanks

    • It shouldn’t be an issue. It’s an amino acid present in meats and plant based proteins. Always make sure to read the label beforehand and follow the instructions.

  16. JE says:

    I just heard about this from a woman working for Vitamin World. She’s taking it and said she’s seen results.
    Is there a certain brand of L-Gultamine you should take.

  17. Rhonda says:

    I was wondering if I eat fermented foods, drink water kefir, eat ginger, coconut oil. eat clean as I can (daily) do I still need to take a probiotic with the glutamine?

    • It depends on many different factors including the state of your gut and whether or not you have leaky gut, how severe it is, how many food intolerances you may have, your health goals, etc. Also, there are many different types of probiotics. The ones present in your food may be different strains than the ones in a supplement. I personally do both.

  18. mary says:

    Is this also a good supplement for Diverticulosis? What else would you suggest ? Thanks in advance Dr. Axe!

  19. Mike says:

    Hi..thanks for a great article. I’m pretty sure I have leaky gut as my GP said that I have proteins circulating in the gut. I also have a compromised immune system. I was wondering if you know much about Kefir & weather you think that might help? I will also start supplementing with L Glutamine as I work out regularly & feel pretty tired a lot if not most of the time… Thanks again ;)

  20. Mike says:

    Thanks for that ;) One other question . Do you think that Paleo is generally the healthiest diet to follow. I have just ordered a book by Chris Kresser which seems like a really sensible approach ? Thanks

  21. Mike says:

    Thanks heaps ;)

  22. JE says:

    Should you take an enzyme with a probiotic? I’ve been drinking Kefir “brand from trader joe’s”. Are you familiar with their brand? Can you take L-glutamine while on iron or any diuretic.

    • If you have a digestive issue, it makes sense to take a digestive enzyme as well. You should have no issues taking L-glutamine while on iron or a diuretic.

  23. Jackie says:

    Do you think that this would be safe and effective to supplement for a 12 lb. dog with IBS? (vets are even more resistant than medical docs for trying natural ‘remedies’ IMHO)

    • I don’t know how safe it would be for dogs to consume the glutamine, I will look into it. I would check the food you are giving your dog to make sure it is whole, grain free, without fillers and high in good protein. You might consider giving the dog small amounts of kefir which could help his gut.

  24. rachel says:

    Hi Dr Axe, I just wanted to ask if the 5gm of glutamine twice a day is based off clinical studies, or is this amount what you have found most effective in your clinical practice. Thanks for all the great info that you produce.

  25. Julie C says:

    Thanks for the great information and recipes provided in your emails.

    Julie

  26. Sue says:

    I was diagnosed with CFS due to having Epstein Barr Virus several years prior. Continue to have
    ” energy crashes” and other issues that go along with CFS. Also had current test showing high oxidative stress. Would it be beneficial to take
    l-glutamine? Thank you so much for the information. Blessings

  27. Beth says:

    How do you know if you have leaky gut? Do you need to be diagnosed with it by a doctor? I have psoriasis — have had it for 35-40 years. Its been worse in my adult years — especially over the past year or two. I’m not 47. Is this something I need to try?

  28. Lise says:

    I’ve recently stumbled across your site and am finding such a positive wealth of information! About a year and a half ago, my daughter was diagnosed with leaky gut and a host of food sensitivites. In this time, we have worked really hard to eat clean, lots of healing foods. (Grass fed beef, green vegetables, probiotic foods, nuts, etc) She has been pretty much symptom free (eczema) for about six months. I just started adding in great lakes gelatin into our diets (smoothies and home made jello. ) Would this be a good source of l glutamine? Or do you think a supplement is necessary.

  29. Brenda says:

    I am interested in knowing how you take the powder with a meal.

  30. Mike says:

    Hi again…I re read my post & realised I meant to say proteins circulating in the blood…not gut…but gather you understood what I meant anyway lol ;)

  31. Kristin says:

    How can you take your L-Glutamine powder if you are not adding it to a protein drink? Mix with water & drink??

    • Exactly! It doesn’t take much water for it to dissolve so it’s really easy to drink. If you wanted, you could also add it to a veggie juice or coconut water or something with a little flavor.

  32. Lisa says:

    In 2009 my stomach had severe pain, to where I was afraid to eat (imagine!) After a dr. confirmed the stomach lining (mucosa) had been compromised… likely due to NSAIDS, I read that beta-carotene helped stomach lining, drank carrot juice and pain was relieved. I also read about Glutamine and have been supplementing with it, although at much lower levels than you recommend. From this article I am going to step up daily intake closer to your recommendation although I have capsule form and will be more difficult. Recently I read articles about Atrophic Gastritis. I believe this is an explanation for what happened to me, and is the “technical” term for leaky gut. I match the description, having Hashimoto’s dx in 2008. Twice it’s found I have no H Pylori, so I conclude it was the autoimmune cause. Also pre-cancerous spots found in my stomach during endoscopy, matching the description of the condition – now I am in high gear focusing on repairing stomach. Recent IgG tests show no allergy to wheat or gluten, but to brewer’s yeast! It is a long, expensive road getting to inflammation causes. Thanks for articles on causes and treatments, as no doctor I’ve had has been able to do that.

  33. SharonC says:

    I saw that you take the powder can you recommend a capsule?

  34. Lorrie says:

    I recently started taking the Motiff Amino Starter for stomach issues (the doc thinks it’s minor gastroparesis) This is my second day. I take one scoop in 16oz of water with some berries thrown in for sugar. But I notice that when I drink it, I get a dizzy…. almost drunk feeling. Is this normal when starting out a supplement like this?

    Thank you!

  35. lorraine says:

    Hi, may I first thank you for all the amazing help you give us. At my age (in my seventies) its been quite a thing to go natural, but this gutsy ol’ lady takes on anything!
    I was wondering seeing that I make and drink Kombucha and kefir grains every day, would that be sufficient to keep the gut bacterias behaving themselves?
    Thanks again and blessings from South Africa.

    • That’s great! But when consuming probiotics you want a lot of different strains so I would try to incorporate fermented foods that are rich in probiotics in addition to what you’re consuming.

  36. JR says:

    I was told I had fatty deposits in my organs I’m assuming there’s absorption issue in my body. Does this means leaky gut? I have been drinking warm lemon water to cleanse my liver. Is there a L-glutamine i can pick up at a health store..now. I make my own smoothie in the morning with spinach, kale, blueberries,kefir, sometimes, apple cider vinegar, aloe juice and kombucha. Does that sound pretty good. I just want to have my gut not feel like something moving inside.
    One last thing, how can you get rid of fibroid(sp?) naturally.

    Thank you for responding to our questions, most professionals don’t. but I see it’s not about the money but about helping people feel better.

  37. lorraine says:

    Hi, I might just add, I have major allergies including most of the anti biotics, have no gall bladder no thyroid use eltroxin, severe asthma severe arthritis osteo, in a wheel chair, and an ulcer. Battle terribly with Rosacea (actually experimenting with magnesium oil spray with a few drops of lavender!) As I mentioned above I am in my seventies and not a happy camper, also cannot go out and buy a million supplements to help me. Also had glandular cancer many years ago, lost my daughter to breast cancer 12 yrs ago and she was only 35! So absolutely any help that I may be able to afford would be awwsimmmmmmmm! Forgot to mention the hypertension,. I am so sick and tired of all the medications and the anti-depressants, lost my hubby to Parkinsons.
    Its difficult to believe I was a South African Gymnast, and ballet dancer for 20 years. Blessings

  38. George Stuart says:

    came across the video on resistance band exercises and when I went to return to watch it could not find it .Have searched the website high and low and still have not found it . Can you please tell me how to get to it

    Many Thanks

  39. Christian Behrens says:

    I’m training for a marathon, I’m right now in the peaks weeks (80-100km x week). How, how many and when can I use L-Glutamine?? Thanks a lot for your help!!

  40. ghada says:

    hi dr Axe ,Iam suffering from h.pylori along with parasites what should i do if i dont want to take all the antibiotic the doctor gave me , i prefer to treat it naturally , i fell pain and bloating in my stomach .

  41. ghada says:

    Hi Dr Axe ,I am taking manuka honey for more than two months with apple cider vinegar and 3 cloves of fresh garlic 2x a day but still in pain should i switch to your protocol to kill that bad bacteria , i read about oregano oil and other essential oils are they safe to take internally and about mastic gum please need your advice ,i will try my best not take the antibiotic ,i hope i will success .

  42. ghada says:

    thank you so much Dr Axe for your help and reply ,at least i know that i am doing right ,I will continue , i want to ask you about bone broth can replace l-glutamine and if it is the normal one we do it for cooking or has specific ingredients .

  43. Cheryl says:

    Approximately how many teaspoons would 5 grams be?

  44. kim says:

    I read somewhere that taking b12 with the l glutamine will help with build up with the product is this true if so how much b12 do I take ty so much

  45. Islam says:

    Dr. Axe many thanks for your opinion and great informative articles you publish. With regards to L-Glutamine Supplementing, what do you think of Glutamine tablets like GNC Glutamine tablets? And also, what would you recommend for Paleo Nutrition enthusiasts when eating natural food sources for Glutamine, apart from Raw cultured Dairy sources?

    Many thanks and all the best!

  46. Christa says:

    I have always read that glutamine should NOT be taken with a meal that contains protein, as it has to compete for absorption with the other amino acids. Therefore it should be taken on an empty stomach. You have recommended to take glutamine with food. Is there a particular reason for this?

    Thanks!

    • It may compete with others but food helps increase glutamine absorption overall, regardless. I am coming out with a leaky gut supplement that will be tied to an amino acid so that it does not have to be taken with food in order to reach full absorption potential.

  47. gary malcik says:

    stomach lining and L glutamine

  48. Kaye says:

    Hi Dr. Axe,
    I have been taking l-glutamine long term, for over a year per a nutrition coach…2 grams, 3 x daily. Since July, I have had this mystery edema occuring only in my legs. I am super-healthy and eat super-healthy, labs point nowhere, and can’t seem to attribute this to anything else. Could my long term use of l-glutamine be the cause?

    • I’ve never heard of it having this type of effect so I don’t think that would be the culprit. I would try to get a little more movement in throughout the day and not sit or stand for long periods of time.

  49. Anh says:

    Hi Dream.Axe, I’m currently taking 3 different medications for high blood pressure. If I take L-Glutamine, is it going to raise my blood pressure. Thank you.

  50. Amy says:

    Is it okay to take the tablets instead of powder? If, no – why not? Thx!

  51. Connie Markley says:

    Is there any connection with MSG?

  52. Denise Herrera says:

    Is this safe to take during pregnancy?

  53. nancy says:

    My local heal food store highly recommended this to me last Saturday also, but I was at my limit financially, so I didn’t buy it.
    We are on a very tight budget and just don’t have the $42 to buy the one you use.
    Can you suggest a less expensive brand?
    I’m almost 62 and have been a T1 Diabetic for over 46 years and have had digestion issues since before then.
    Thx for any recommendations.
    Happy Thanksgiving to you all!

    • Rose says:

      Powder city.com sells it in bulk powder, they ship free and also have a 10% off coupon. 1 kilo approx. $ 27.00. That’s a lot of L Glutamine.
      Good Luck, Rose !

    • Greg says:

      Search the internet for deals and buy it in powder form that is cheaper. I just bought some a while back and it wasn’t anywhere near $42. Hope this helps.

  54. Jill Nau says:

    Would glutamine interfere or be bad to take with any medications?

  55. Krissy says:

    I’ve tried L-Glutamine but get sinus inflammation/migraines every time (my default reaction). Same with bone broth. I am sensitive to almost everything I eat so eat AIP and take entirely too much silver just to get by. I believe it’s leaky gut but all the best healers make me sick. Any other suggestions? Glutamine sounded like it would be the thing to fix me, but no dice. (Hashimoto’s for 15 years and hypothyroid before that, Reynaud’s syndrome, fatigue, brain fog, constant sinus battles, pain, neuropathy in all limbs and lately numbness in face) Thank you.

  56. Laura says:

    Dr. Axe – I have Pure Encapsulations brand of L-Glutamine capsules and had been taking 1g/day until I read this article. Am trying to heal a leaky gut so planned to work my way up to 5g twice a day. Took 4g the other morning and within 2 hours was doubled over with vomiting and diarrhea. Obviously I need yo back off on the dosage, but I have to say, the reaction scared me given how safe this supplement is supposed to be. Can you tell me why I might have experienced that reaction and how I might titrate the dosage in the future (assuming I am brave enough to try again!)

  57. Teacher Randall says:

    Hey Dr. Axe you can’t do this, this is the internet. A website with actual research cited for claims made is breaking the unwritten rule of the internet. All articles must make at least ten claims per one citations, and that citation must be to another website which must have another website as its source never reaching an actual research paper. lol

    but besides that great job! :D.

  58. Karen says:

    I read in a magazine article recently that glutamine can help with weight loss. Is this true?

  59. Laura says:

    Hi Dr. Axe – sure hoping you see this; I can’t seem to find an answer to this question: I had been taking just 1g of l-Glutamine and wasn’t notcing anything so did some research about dosages. Found your blog among others that suggests it is quite safe at higher doses, say 3-5g 2-3 times per day. So one day recently I took 4g on an empty stomach, followed by a smoothie about an hour later. Two hours after taking the supplement I was doubled over with diarrhea and vomiting. It was very alarming. Obviously that dose didn’t work for me, but what I wish I knew is what might be going on in my gut to have caused this reaction? Lastly, how would you recommend I titre my doses in the future? Thanks so much!

    • If you feel that 1g is doing nothing, try increasing to 1.5g slowly and see how your body does over a period of time. If it tolerates it well, after a week or 2, try adding another .5g

  60. Kristina says:

    Hi Dr. Axe, i have been trying to heal my gut since July 2014, i have cut out grains, gluten, soy, wheat but still eat some dairy. I have also been taking 3-7 HCL pills depending on the meal I am eating. I take a propiotic every day in the AM and take oil of oregano once at night. i just received my NOW brand powder L-Glutamine and i had read to take 40g a day so last night I had 10g in a smoothie before supper. After supper I had another 10g in some juice. This morning I had 10g more in some water with some fruit. It’s lunch time so I was about to have 10 more grams. Now I read this and I am starting to worry about how much I’ve taken! I wonder why there is such a discrepancy on what sites recommend. If i am fine taking 40g a day should I continue or no? I am 5’5″ 115 lb femaie.

  61. Lisa H says:

    How do I find a Dr. in my area that treats like Dr. Axe does? Is it Fundamental Medicine? I need a Dr. who specializes in an auto-immune hyper-thyroid condition. I am in the Seattle, WA area.

  62. Christine says:

    I am trying to heal up a leaky gut, but when I tried glutamine (5g once a day) I had the worst constipation I have ever had. (Similar effect with high quality gelatin – I don’t have the time to make bone broth.) I tried adding a stool softener, adding pectin for soluble fiber, lots of water, etc. and I already take a probiotic, but the only thing that helped was a laxative – not fun! Is there any way to take this stuff to avoid severe pain and a non-working digestive tract?

  63. Michelle says:

    I have just purchased a few supplements that you suggest for leaky gut (Qucertin, Licorice Root, Papaya Digestive Enzymes, etc.) but since I’ve never taken L-Glutamine before and you suggest powder if this supplement dosage would be fine? Its 1500 mg’s in capsule form? Also how long should you remain on these supplements to repair gut health?

    Dietary Supplement•1500mg Dose to Prime Muscles for Workouts
    •Provides Anti-Catabolic Effects & Supports Muscle Function
    •Supports Faster Recovery After workouts
    Glutamine is one of the most abundant amino acids found in muscles. It is involved in protein synthesis and plays an important role in hydrating muscle cells. With this amino acid’s great benefits in the body, it will support muscle function.

  64. Sharon GoddardWa says:

    Want to make sure L Glutamine is ok for type 1 diabetic.

  65. Scarlett says:

    Quite shocked and very disappointed that this article doesn’t discuss side effects to taking L-Glutamine. I had severe side effects, including insommnia, loss of appetite, and (bizarrely) a fear of going out and confronting problems/Iissues that arose with other people. I mentioned these symptoms to a friend and she had exactly the same experience. Both pf us were taking the supplement prescribed by our respective naturopaths. I’m disappointed because I expected to read more responsible advice than has been given here. People should be helped to become aware of the detrimental effects of supplements as well. This is a very powerful supplement and needs to be respected.

  66. Sharon says:

    Hi Dr Axe

    Is L-Glutamine safe when pregnant and breast feeding?

    Thanks :)

  67. Amy says:

    Very well written and informative article. My son has multiple food allergies and I spend a good amount of time researching natural healing options for him. This seems like a great option. But I must say I am confused. In my research I have run across doctors who claim that foods high in glutamate should be avoided. Why are there so many differing opinions? eg

  68. Betty Jo Woodcock says:

    I have peripheral neuropathy, which is quite painful. Also have Charcot’s foot on the left. A friend suggested L-Glutamine Powder. I have taken it 3 times a day for only one day. So far, the foot pain has decreased and I hope that it is due to the powder. Any suggestions would be appreciated.

    • I would look for a maximized living chiropractor in your area and also check this out:
      You may also benefit from a vitamin B12, omega d3 supplements and a diet higher in fat and low in sugar

  69. Denise Marie Hardman says:

    Does L-Glutamine help to reduce the symptoms of Restless Leg Syndrone?